{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:50:42Z","timestamp":1789984242681,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7640,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,10]]},"abstract":"\n \n \n We have developed a quantitative functional imaging study of the liver using a radiolabeled asialoglycoprotein analog, Tc\u2013galactosyl\u2013neoglycoalbumin. Heart and liver time\u2013activity data can be transformed by automated kinetic analysis into asialoglycoprotein hepatocyte receptor concentration. Twenty\u2013eight healthy controls, 46 patients with noncholestatic chronic liver injury and 11 patients with primary biliary cirrhosis were studied. Liver function was also assessed by Pugh modified\u2013Child\u2013Turcotte criteria, 14C\u2013aminopyrine breath test and indocyanine green clearance (24 patients). Results: (a) In normal controls with a Child\u2013Turcotte criteria score of 5, receptor concentration ranged from 0.63 to 1.19 \u03bcmol\/L, with a mean 0.83 \u00b1 2 S.D. 0.06 \u03bcmol\/L, which was significantly higher (p < 0.001) than that of the patient group (mean receptor concentration = 0.44 \u00b1 2 S.D. 0.04 \u03bcmol\/L). In cirrhotic patients with Child\u2013Turcotte criteria score of 5, the mean receptor concentration was 0.60 \u00b1 2 S.D. 0.07 \u03bcmol\/L, which was significantly lower than controls (p < 0.01). In end\u2013stage cirrhosis (Child\u2013Turcotte criteria score 11 to 15), a group in which patients died or required orthotopic liver transplantation within 1 yr, the mean receptor concentration was 0.35 \u00b1 2 S.D. to 0.07 \u03bcmol\/L. The sensitivity and specificity for receptor concentration in relation to liver disease, with values above 0.65 \u03bcmol\/L being normal, were 0.96 and 0.88, respectively. Receptor concentration correlated well with Child\u2013Turcotte criteria score (r = 0.78, p = <0.001), with aminopyrine breath test (r = 0.75, p = <0.001) and with indocyanine green clearance (r = 0.88, p = <0.001). (b) Among 11 primary biliary cirrhosis patients, ten had Child\u2013Turcotte criteria score of 5. Receptor concentration and aminopyrine breath test values were lower in primary biliary cirrhosis patients with liver biopsy histological stage III\u2013IV than I\u2013II, although the numbers were too small for statistical analysis. We conclude that determination of receptor concentration, a rapid and bilirubin\u2013independent method of quantitating hepatocellular function, correlates well with Child\u2013Turcotte criteria score, aminopyrine breath test and indocyanine green clearance. This could prove valuable in evaluating the extent and the progression of liver disease and the impact of newer therapies in retarding chronic cholestatic and viral liver injury. Long\u2013term studies are needed to confirm this speculation. 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