{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:38:37Z","timestamp":1792712317606,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7640,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Tau protein is a member of the family of microtubule\u2013associated proteins, which support microtubule polymerization and stability. Under pathological conditions, tau is a major constituent of neurofibrillary tangles in nerve cells of patients with Alzheimer's disease. Neurofibrillary tangles share some morphological, biochemical and immunological properties with cytoplasmic inclusions associated with other diseases, such as Mallory bodies in the livers of patients with alcoholic hepatitis and in corresponding mouse models. Recently a Mallory body component was identified that in molecular mass and isoelectric point resembles the abnormally phosphorylated tau of neurofibrillary tangles. There has been, however, so far no report describing the occurrence of tau in normal liver. We now demonstrate the expression of two tau isoforms containing three and four repeats, respectively, of the microtubule\u2013binding domains in normal mouse liver and kidney. This finding provides evidence for a physiological role of tau in the liver and, consequently, the basis for the involvement of tau in pathological situations. (Hepatology 1994;20:1086-1089).<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840200442","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T03:26:58Z","timestamp":1172978818000},"page":"1086-1089","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Expression of Three\u2013 and Four\u2013Repeat Tau Isoforms in Mouse Liver"],"prefix":"10.1097","volume":"20","author":[{"given":"Lukas","family":"Kenner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuf","family":"El-Shabrawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Hutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forstner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Zatloukal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Hoefler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Preisegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kurzbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Denk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840200442-BIB1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ana.410260308","volume":"26","author":"Kosik","year":"1989","journal-title":"Ann Neurol"},{"key":"10.1002\/hep.1840200442-BIB2","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1083\/jcb.101.4.1371","volume":"101","author":"Binder","year":"1985","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840200442-BIB3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1083\/jcb.102.1.252","volume":"102","author":"Peng","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840200442-BIB4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ana.410220514","volume":"22","author":"Kowall","year":"1987","journal-title":"Ann Neurol"},{"key":"10.1002\/hep.1840200442-BIB5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0306-4522(88)90013-9","volume":"25","author":"Brion","year":"1988","journal-title":"Neuroscience"},{"key":"10.1002\/hep.1840200442-BIB6","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.1840200442-BIB7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0022-2836(77)90213-3","volume":"116","author":"Cleveland","year":"1977","journal-title":"J Mol Biol"},{"key":"10.1002\/hep.1840200442-BIB8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0169-328X(86)90033-1","volume":"1","author":"Neve","year":"1986","journal-title":"Mol Brain Res"},{"key":"10.1002\/hep.1840200442-BIB9","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1128\/MCB.9.4.1389","volume":"9","author":"Himmler","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1002\/hep.1840200442-BIB10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/197192b0","volume":"197","author":"Kidd","year":"1962","journal-title":"Nature"},{"key":"10.1002\/hep.1840200442-BIB11","first-page":"77","volume":"20","author":"Denk","year":"1979","journal-title":"Int Rev Exp Pathol"},{"key":"10.1002\/hep.1840200442-BIB12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0168-8278(87)80065-X","volume":"5","author":"Tsunoo","year":"1987","journal-title":"J Hepatol"},{"key":"10.1002\/hep.1840200442-BIB13","first-page":"193","volume":"66","author":"Preisegger","year":"1992","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840200442-BIB14","doi-asserted-by":"crossref","first-page":"5350","DOI":"10.1073\/pnas.74.12.5350","volume":"74","author":"Alwine","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.1840200442-BIB15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.3122323","volume":"239","author":"Lee","year":"1988","journal-title":"Science"},{"key":"10.1002\/hep.1840200442-BIB16","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","volume":"74","author":"Sanger","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.1840200442-BIB17","volume-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"1989","unstructured":", , eds. Molecular cloning: a laboratory manual. 2nd ed., Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989."},{"key":"10.1002\/hep.1840200442-BIB18","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","volume":"85","author":"Goedert","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.1840200442-BIB19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.121.2.257","volume":"121","author":"Wang","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840200442-BIB20","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1128\/MCB.9.4.1381","volume":"9","author":"Himmler","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1002\/hep.1840200442-BIB21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","volume":"8","author":"Goedert","year":"1989","journal-title":"EMBO J"},{"key":"10.1002\/hep.1840200442-BIB22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0074-7696(08)61528-4","volume":"124","author":"Wiche","year":"1991","journal-title":"Int Rev Cytol"},{"key":"10.1002\/hep.1840200442-BIB23","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.1198096","volume":"190","author":"Baraona","year":"1975","journal-title":"Science"},{"key":"10.1002\/hep.1840200442-BIB24","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1172\/JCI105200","volume":"44","author":"Lieber","year":"1965","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840200442-BIB25","first-page":"455","volume":"41","author":"Matsuda","year":"1979","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840200442-BIB26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1083\/jcb.84.1.28","volume":"84","author":"Reaven","year":"1980","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840200442-BIB27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/978-3-642-70048-4_8","volume-title":"Alcohol related diseases in gastroenterology","author":"Denk","year":"1985","unstructured":"Ethanol, Mallory bodies, and the microtubular system. In: , eds. Alcohol related diseases in gastroenterology. Berlin: Springer-Verlag, 1985: 154\u2013171."},{"key":"10.1002\/hep.1840200442-BIB28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0163-7258(90)90032-W","volume":"46","author":"Lieber","year":"1990","journal-title":"Pharmacol Ther"},{"key":"10.1002\/hep.1840200442-BIB29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0896-6273(93)90279-Z","volume":"11","author":"Biernat","year":"1993","journal-title":"Neuron"},{"key":"10.1002\/hep.1840200442-BIB30","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1523\/JNEUROSCI.07-11-03736.1987","volume":"7","author":"Perry","year":"1987","journal-title":"J Neurosci"},{"key":"10.1002\/hep.1840200442-BIB31","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1073\/pnas.85.12.4506","volume":"85","author":"Wischik","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.1840200442-BIB32","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1002\/j.1460-2075.1991.tb07820.x","volume":"10","author":"Jakes","year":"1991","journal-title":"EMBO J"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840200442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199410000-00041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:20:22Z","timestamp":1733052022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199410000-00041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840200442","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}