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The clinical course was characterized by severe jaundice lasting 22 mo, intense pruritus, fever, steatorrhea, high alkaline phosphatase levels and hypercholesterolemia. Jaundice resolved with initiation of ursodeoxycholic acid therapy, but subclinical cholestasis and low-level inflammatory activity persisted and ultimately evolved into biliary cirrhosis. The pathological substrate of this severe and prolonged cholestatic reaction was found to be the vanishing bile duct syndrome with a marked transient pseudoxanthomatosis. (Hepatology 1994;20:1437-1441).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840200610","type":"journal-article","created":{"date-parts":[[2007,3,10]],"date-time":"2007-03-10T15:35:09Z","timestamp":1173540909000},"page":"1437-1441","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":110,"title":["Chlorpromazine-induced vanishing bile duct syndrome leading to biliary 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