{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:14:48Z","timestamp":1784758488094,"version":"3.55.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4230,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hepatic hemosiderosis and increased iron absorption are common findings in cirrhosis. It has been proposed that a positive relation exists between intestinal iron absorption and the development of hepatic hemosiderosis. The current study investigated the duodenal expression of the iron transport molecules divalent metal transporter 1 (<jats:italic toggle=\"yes\">DMT1<\/jats:italic> [<jats:italic toggle=\"yes\">IRE<\/jats:italic>]), iron-regulated gene 1 (<jats:italic toggle=\"yes\">Ireg1<\/jats:italic> [<jats:italic toggle=\"yes\">ferroportin<\/jats:italic>]), <jats:italic toggle=\"yes\">hephaestin<\/jats:italic>, and duodenal cytochrome b (<jats:italic toggle=\"yes\">Dyctb<\/jats:italic>) in 46 patients with cirrhosis and 20 control subjects. Total RNA samples were extracted from duodenal biopsy samples and the expression of the iron transport genes was assessed by ribonuclease protection assays. Expression of <jats:italic toggle=\"yes\">DMT1<\/jats:italic> and <jats:italic toggle=\"yes\">Ireg1<\/jats:italic> was increased 1.5 to 3-fold in subjects with cirrhosis compared with iron-replete control subjects. The presence of cirrhosis <jats:italic toggle=\"yes\">per se<\/jats:italic> and serum ferritin (SF) concentration were independent factors that influenced the expression of <jats:italic toggle=\"yes\">DMT1<\/jats:italic>. However, only SF concentration was independently associated with <jats:italic toggle=\"yes\">Ireg1<\/jats:italic> expression. In cirrhosis, the expression of <jats:italic toggle=\"yes\">DMT1<\/jats:italic> and <jats:italic toggle=\"yes\">Ireg1<\/jats:italic> was not related to the severity of liver disease or cirrhosis type. There was no correlation between the duodenal expression of <jats:italic toggle=\"yes\">DMT1<\/jats:italic> and <jats:italic toggle=\"yes\">Ireg1<\/jats:italic> and the degree of hepatic siderosis. In conclusion, the presence of cirrhosis is an independent factor associated with increased expression of <jats:italic toggle=\"yes\">DMT1<\/jats:italic> but not <jats:italic toggle=\"yes\">Ireg1<\/jats:italic>. The mechanism by which cirrhosis mediates this change in <jats:italic toggle=\"yes\">DMT1<\/jats:italic> expression has yet to be determined. Increased expression of <jats:italic toggle=\"yes\">DMT1<\/jats:italic> may play an important role in the pathogenesis of cirrhosis-associated hepatic iron overload. (Hepatology 2004;39:492-499.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.20038","type":"journal-article","created":{"date-parts":[[2004,2,3]],"date-time":"2004-02-03T17:05:53Z","timestamp":1075827953000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis"],"prefix":"10.1097","volume":"39","author":[{"given":"Katherine Anne","family":"Stuart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Jon","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Michael","family":"Frazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese 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