{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:07:13Z","timestamp":1790755633782,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4048,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The impact of primary biliary cirrhosis (PBC) on health-related quality of life (HRQOL) is poorly documented. We assessed quality of life in a group of 276 unselected patients with PBC using the Nottingham Health Profile (NHP). This is a generic scale that assesses six major areas commonly associated with HRQOL. Data were compared with those of a sex- and age-matched control group. The associations between NHP scores and the severity of PBC were tested. Patients (86% women) had a median age of 62 years (range 33-87). Most patients were treated with UDCA. PBC patients showed a strong statistically significant difference in energy compared to controls (respectively, 40.6 vs. 22.9, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .0001) and had worse scores for emotional reactions (22.2 vs. 16.1, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .005). No other differences were observed. No associations of the dimension subscores were found with biochemical liver tests, histological stages, or duration of the disease. Among the signs or symptoms, fatigue was the finding most often associated with the dimension subscores. <jats:underline>In conclusion<\/jats:underline>, patients with PBC feel that their overall quality of life is worse than that of the control population. This difference is mainly due to the decrease in the subscores of energy and emotional reactions, both associated with fatigue. These effects must be taken into account by clinicians when treating these patients, as they constitute the clinical outcomes that have the most impact on patients\u2019 lifestyle and adherence to treatment. (Hepatology 2004;40:489-494.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.20276","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T18:05:28Z","timestamp":1092420328000},"page":"489-494","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":127,"title":["Quality of life in patients with primary biliary cirrhosis"],"prefix":"10.1097","volume":"40","author":[{"given":"Ren\u00e9e Eug\u00e9nie","family":"Poupon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Chr\u00e9tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chazouill\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Poupon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Chwalow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20241201","doi-asserted-by":"crossref","first-page":"497502","DOI":"10.1111\/j.1572-0241.2000.01774.x","article-title":"Cholestatic liver diseases and health-related quality of life.","volume":"95","author":"Younossi","year":"2000","journal-title":"Am J Gastroenterology"},{"key":"R2-28-20241201","doi-asserted-by":"crossref","first-page":"705710","DOI":"10.1136\/gut.43.5.705","article-title":"Fatigue in primary biliary cirrhosis.","volume":"43","author":"Cauch-Dudek","year":"1998","journal-title":"Gut"},{"key":"R3-28-20241201","doi-asserted-by":"crossref","first-page":"760767","DOI":"10.1111\/j.1572-0241.2000.01857.x","article-title":"Impact of fatigue on the quality of life in patients with primary biliary cirrhosis.","volume":"95","author":"Huet","year":"2000","journal-title":"Am J Gastroenterology"},{"key":"R4-28-20241201","doi-asserted-by":"crossref","first-page":"12351241","DOI":"10.1053\/gast.2002.32993","article-title":"The true impact of fatigue in primary biliary cirrhosis: a population study.","volume":"122","author":"Goldblatt","year":"2002","journal-title":"Gastroenterology"},{"key":"R5-28-20241201","doi-asserted-by":"crossref","first-page":"129134","DOI":"10.1016\/S0168-8278(96)80064-X","article-title":"Quality of life, major medical complications and hospital service utilization in patients with primary biliary cirrhosis after liver transplantation.","volume":"25","author":"Navasa","year":"1996","journal-title":"J Hepatology"},{"key":"R6-28-20241201","doi-asserted-by":"crossref","first-page":"356364","DOI":"10.1002\/hep.510290229","article-title":"Quality of life before and after liver transplantation for cholestatic liver disease.","volume":"29","author":"Gross","year":"1999","journal-title":"HEPATOLOGY"},{"key":"R7-28-20241201","first-page":"221229","article-title":"The Nottingham Health Profile: subjective health status and medical consultations.","volume":"15","author":"Hunt","year":"1981","journal-title":"Soc Sci Med"},{"key":"R9-28-20241201","first-page":"103112","article-title":"Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Archives A.","volume":"379","author":"Ludwig","year":"1978","journal-title":"Path Anat Histol"},{"key":"R11-28-20241201","doi-asserted-by":"crossref","first-page":"170178","DOI":"10.1053\/gast.2001.21193","article-title":"Factors associated with poor health-related quality of life of patients with cirrhosis.","volume":"120","author":"Marchesini","year":"2001","journal-title":"Gastroenterology"},{"key":"R12-28-20241201","doi-asserted-by":"crossref","first-page":"209212","DOI":"10.1002\/hep.510270132","article-title":"Chronic hepatitis C infection causes a significant reduction in quality of life in the absence of cirrhosis.","volume":"27","author":"Foster","year":"1998","journal-title":"HEPATOLOGY"},{"key":"R13-28-20241201","first-page":"473482","article-title":"The MOS 36-item short form health survey (SF 36). Conceptual framework and item selection.","volume":"45","author":"Ware","year":"1992","journal-title":"Medical Care"},{"key":"R14-28-20241201","doi-asserted-by":"crossref","first-page":"S79S83","DOI":"10.1093\/clinids\/18.Supplement_1.S79","article-title":"Measuring the functional impact of fatigue: initial validation of the Fatigue Impact Scale.","volume":"18","author":"Fisk","year":"1994","journal-title":"Clin Infect Diseases"},{"key":"R15-28-20241201","doi-asserted-by":"crossref","first-page":"753762","DOI":"10.1016\/0022-3999(93)90104-N","article-title":"The measurement of fatigue: a new instrument.","volume":"37","author":"Schwartz","year":"1993","journal-title":"J Psychosom Res"},{"key":"R16-28-20241201","doi-asserted-by":"crossref","first-page":"924929","DOI":"10.1053\/jhep.2000.19067","article-title":"Reliability and validity of the NIDDK-QA instruments in the assessment of quality of life in ambulatory patients with cholestatic disease.","volume":"32","author":"Kim","year":"2000","journal-title":"HEPATOLOGY"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.20276","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200408000-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T12:13:21Z","timestamp":1733055201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200408000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.20276","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}