{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:00:56Z","timestamp":1765609256973},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4261,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1002\/hep.20379","type":"journal-article","created":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T23:01:15Z","timestamp":1095721275000},"page":"925-932","source":"Crossref","is-referenced-by-count":15,"title":["Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree"],"prefix":"10.1097","volume":"40","author":[{"given":"Kenichi","family":"Harada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Isse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2004]]},"reference":[{"key":"10.1002\/hep.20379-BIB1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1067\/mic.2000.107071","volume":"28","author":"Sheen-Chen","year":"2000","journal-title":"Am J Infect Control"},{"key":"10.1002\/hep.20379-BIB2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0168-8278(00)80153-1","volume":"33","author":"Hiramatsu","year":"2000","journal-title":"J Hepatol"},{"key":"10.1002\/hep.20379-BIB3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0168-8278(98)80058-5","volume":"29","author":"Sasatomi","year":"1998","journal-title":"J Hepatol"},{"key":"10.1002\/hep.20379-BIB4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH776>3.0.CO;2-H","volume":"193","author":"Harada","year":"2001","journal-title":"J Pathol"},{"key":"10.1002\/hep.20379-BIB5","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/JCM.38.3.1072-1076.2000","volume":"38","author":"Nilsson","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1002\/hep.20379-BIB6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF01296423","volume":"37","author":"Sung","year":"1992","journal-title":"Dig Dis Sci"},{"key":"10.1002\/hep.20379-BIB7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0046-8177(88)80150-3","volume":"19","author":"Nakanuma","year":"1988","journal-title":"Hum Pathol"},{"key":"10.1002\/hep.20379-BIB8","first-page":"163","volume":"152","author":"Tabata","year":"1984","journal-title":"Prog Clin Biol Res"},{"key":"10.1002\/hep.20379-BIB9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0168-8278(92)90028-N","volume":"15","author":"Saito","year":"1992","journal-title":"J Hepatol"},{"key":"10.1002\/hep.20379-BIB10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF02774329","volume":"24","author":"Sugiura","year":"1989","journal-title":"Gastroenterol Jpn"},{"key":"10.1002\/hep.20379-BIB11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00042737-200107000-00003","volume":"13","author":"Fellermann","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1002\/hep.20379-BIB12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/rr25","volume":"1","author":"Bals","year":"2000","journal-title":"Respir Res"},{"key":"10.1002\/hep.20379-BIB13","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.4049\/jimmunol.169.5.2516","volume":"169","author":"Yamaguchi","year":"2002","journal-title":"J Immunol"},{"key":"10.1002\/hep.20379-BIB14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1357-2725(99)00013-8","volume":"31","author":"Schroder","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1002\/hep.20379-BIB15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1046\/j.1365-2362.2000.00696.x","volume":"30","author":"Frye","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"10.1002\/hep.20379-BIB16","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1128\/IAI.67.6.2740-2745.1999","volume":"67","author":"Mathews","year":"1999","journal-title":"Infect Immun"},{"key":"10.1002\/hep.20379-BIB17","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1172\/JCI1861","volume":"101","author":"Valore","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.20379-BIB18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-5793(96)01123-4","volume":"396","author":"Zhao","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1002\/hep.20379-BIB19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1172\/JCI2410","volume":"102","author":"Bals","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.20379-BIB20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/43088","volume":"387","author":"Harder","year":"1997","journal-title":"Nature"},{"key":"10.1002\/hep.20379-BIB21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)81895-4","volume":"88","author":"Goldman","year":"1997","journal-title":"Cell"},{"key":"10.1002\/hep.20379-BIB22","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1128\/IAI.66.9.4222-4228.1998","volume":"66","author":"Krisanaprakornkit","year":"1998","journal-title":"Infect Immun"},{"key":"10.1002\/hep.20379-BIB23","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H","volume":"38","author":"Nakanuma","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1002\/hep.20379-BIB24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/gut.49.4.481","volume":"49","author":"Hamanaka","year":"2001","journal-title":"Gut"},{"key":"10.1002\/hep.20379-BIB25","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/eji.1830171011","volume":"17","author":"Dougherty","year":"1987","journal-title":"Eur J Immunol"},{"key":"10.1002\/hep.20379-BIB26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2957\/kanzo.34.122","volume":"34","author":"Saito","year":"1993","journal-title":"Kanzo"},{"key":"10.1002\/hep.20379-BIB27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2559.1998.00445.x","volume":"33","author":"Sugawara","year":"1998","journal-title":"Histopathology"},{"key":"10.1002\/hep.20379-BIB28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF02623562","volume":"25","author":"Miyagiwa","year":"1989","journal-title":"In Vitro Cell Dev Biol"},{"key":"10.1002\/hep.20379-BIB29","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.gastro.2003.07.013","volume":"125","author":"Kamihira","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.20379-BIB30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1365-2567.2002.01430.x","volume":"106","author":"Duits","year":"2002","journal-title":"Immunology"},{"key":"10.1002\/hep.20379-BIB31","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1097\/01.LAB.0000097190.56734.FE","volume":"83","author":"Harada","year":"2003","journal-title":"Lab Invest"},{"key":"10.1002\/hep.20379-BIB32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0168-8278(01)00084-8","volume":"35","author":"Tsuneyama","year":"2001","journal-title":"J Hepatol"},{"key":"10.1002\/hep.20379-BIB33","doi-asserted-by":"crossref","first-page":"14961","DOI":"10.1073\/pnas.95.25.14961","volume":"95","author":"Singh","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.20379-BIB34","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1046\/j.1471-4159.2001.00305.x","volume":"77","author":"Hao","year":"2001","journal-title":"J Neurochem"},{"key":"10.1002\/hep.20379-BIB35","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0002-9440(10)64423-9","volume":"161","author":"Zen","year":"2002","journal-title":"Am J Pathol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.20379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hep.20379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T12:37:19Z","timestamp":1673440639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hep.20379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.20379","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}