{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:50:04Z","timestamp":1778943004100,"version":"3.51.4"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3744,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1002\/hep.20709","type":"journal-article","created":{"date-parts":[[2005,5,7]],"date-time":"2005-05-07T01:18:27Z","timestamp":1115428707000},"page":"1262-1271","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":45,"title":["An inhibitor of cyclin\u2010dependent kinase, stress\u2010induced p21Waf\u20101\/Cip\u20101, mediates hepatocyte mito\u2010inhibition during the evolution of cirrhosis\u2020"],"prefix":"10.1097","volume":"41","author":[{"given":"John G.","family":"Lunz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Demetris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-9-20250207","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0168-8278(99)80106-8","article-title":"Hepatocyte proliferative activity in human liver cirrhosis","volume":"30","author":"Delhaye","year":"1999","journal-title":"J Hepatol"},{"key":"R2-9-20250207","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF01229074","article-title":"Clinicopathological study of proliferating cell nuclear antigen (PCNA) of hepatocytes in primary biliary cirrhosis","volume":"29","author":"Shibata","year":"1994","journal-title":"J Gastroenterol"},{"key":"R3-9-20250207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1478-3231.2004.00888.x","article-title":"Liver transplantation in the era of model for end\u2010stage liver disease","volume":"24","author":"Wang","year":"2004","journal-title":"Liver Int"},{"key":"R4-9-20250207","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-6135.2004.00403.x","article-title":"Improving liver allocation: MELD and PELD","volume":"4","author":"Freeman","year":"2004","journal-title":"Am J Transplant"},{"key":"R5-9-20250207","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/jlts.2003.50009","article-title":"Longitudinal assessment of mortality risk among candidates for liver transplantation","volume":"9","author":"Merion","year":"2003","journal-title":"Liver Transpl"},{"key":"R6-9-20250207","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: positive and negative regulators of G1\u2010phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev"},{"key":"R7-9-20250207","first-page":"M43","article-title":"p21(WAF1\/Cip1): more than a break to the cell cycle?","volume":"1471","author":"Dotto","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"R8-9-20250207","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1038\/sj.onc.1201728","article-title":"Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver","volume":"16","author":"Albrecht","year":"1998","journal-title":"Oncogene"},{"key":"R9-9-20250207","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0002-9440(10)65034-1","article-title":"The development and compensation of biliary cirrhosis in interleukin\u20106\u2010deficient mice","volume":"156","author":"Ezure","year":"2000","journal-title":"Am J Pathol"},{"key":"R10-9-20250207","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(95)90039-X","article-title":"Mice lacking p21CIP1\/WAF1 undergo normal development, but are defective in G1 checkpoint control","volume":"82","author":"Deng","year":"1995","journal-title":"Cell"},{"key":"R11-9-20250207","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0002-9440(10)64089-8","article-title":"Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1\/Cip1) as a disease marker and the influence of immunosuppressive drugs","volume":"158","author":"Lunz","year":"2001","journal-title":"Am J Pathol"},{"key":"R12-9-20250207","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/sj.onc.1201543","article-title":"p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53\u2010deficient cells","volume":"16","author":"Cayrol","year":"1998","journal-title":"Oncogene"},{"key":"R13-9-20250207","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0002-9440(10)63243-9","article-title":"Regulation and function of trefoil factor family 3 expression in the biliary tree","volume":"165","author":"Nozaki","year":"2004","journal-title":"Am J Pathol"},{"key":"R14-9-20250207","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/hep.510230510","article-title":"Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis","volume":"23","author":"Delhaye","year":"1996","journal-title":"HEPATOLOGY"},{"key":"R16-9-20250207","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1038\/sj.onc.1203045","article-title":"2\u2010Acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression","volume":"18","author":"Trautwein","year":"1999","journal-title":"Oncogene"},{"key":"R17-9-20250207","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0002-9440(10)64167-3","article-title":"STAT\u20103 overexpression and p21 up\u2010regulation accompany impaired regeneration of fatty livers","volume":"161","author":"Torbenson","year":"2002","journal-title":"Am J Pathol"},{"key":"R18-9-20250207","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1111\/j.1530-0277.2002.tb02475.x","article-title":"Ethanol induces redox\u2010sensitive cell\u2010cycle inhibitors and inhibits liver regeneration after partial hepatectomy","volume":"26","author":"Koteish","year":"2002","journal-title":"Alcohol Clin Exp Res"},{"key":"R19-9-20250207","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.1349-7006.1996.tb03117.x","article-title":"Expression of p21(waf\u20101\/cip\u20101) is significantly induced in the livers of LEC rats with chronic liver injury","volume":"87","author":"Sawada","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"R20-9-20250207","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1093\/nar\/26.13.3293","article-title":"Regenerating livers of old rats contain high levels of C\/EBPalpha that correlate with altered expression of cell cycle associated proteins","volume":"26","author":"Timchenko","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"R21-9-20250207","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gad.10.3.245","article-title":"Targeted in vivo expression of the cyclin\u2010dependent kinase inhibitor p21 halts hepatocyte cell\u2010cycle progression, postnatal liver development and regeneration","volume":"10","author":"Wu","year":"1996","journal-title":"Genes Dev"},{"key":"R22-9-20250207","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hep.510250311","article-title":"Regulation of cyclin\u2010dependent kinase inhibitor p21(WAF1\/Cip1\/Sdi1) gene expression in hepatic regeneration","volume":"25","author":"Albrecht","year":"1997","journal-title":"HEPATOLOGY"},{"key":"R23-9-20250207","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0960-9822(02)00452-9","article-title":"Subcellular distribution of p21 and PCNA in normal and repair\u2010deficient cells following DNA damage","volume":"6","author":"Li","year":"1996","journal-title":"Curr Biol"},{"key":"R24-9-20250207","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1101\/gad.8.15.1750","article-title":"p21\u2010containing cyclin kinases exist in both active and inactive states","volume":"8","author":"Zhang","year":"1994","journal-title":"Genes Dev"},{"key":"R26-9-20250207","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/5593","article-title":"Hepatocyte growth factor gene therapy of liver cirrhosis in rats","volume":"5","author":"Ueki","year":"1999","journal-title":"Nat Med"},{"key":"R27-9-20250207","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/jsre.1997.5243","article-title":"Perioperative continuous hepatocyte growth factor supply prevents postoperative liver failure in rats with liver cirrhosis","volume":"74","author":"Kaido","year":"1998","journal-title":"J Surg Res"},{"key":"R28-9-20250207","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.282.5393.1497","article-title":"Requirement for p53 and p21 to sustain G2 arrest after DNA damage","volume":"282","author":"Bunz","year":"1998","journal-title":"Science"},{"key":"R29-9-20250207","doi-asserted-by":"crossref","first-page":"30348","DOI":"10.1074\/jbc.M300996200","article-title":"The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin\u2010induced liver injury","volume":"278","author":"Kwon","year":"2003","journal-title":"J Biol Chem"},{"key":"R30-9-20250207","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/carcin\/23.2.341","article-title":"Formation of 8\u2010hydroxydeoxyguanosine and cell\u2010cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1\/Cip1), cyclin D1 and Ogg1","volume":"23","author":"Kinoshita","year":"2002","journal-title":"Carcinogenesis"},{"key":"R31-9-20250207","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF02256052","article-title":"Oxidative\u2010stress\u2010related changes in the livers of bile\u2010duct\u2010ligated rats","volume":"10","author":"Huang","year":"2003","journal-title":"J Biomed Sci"},{"key":"R32-9-20250207","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and molecular mechanisms of stress\u2010induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes","volume":"35","author":"Toussaint","year":"2000","journal-title":"Exp Gerontol"},{"key":"R33-9-20250207","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/pmic.200300557","article-title":"Copper\u2010associated liver disease: a proteomics study of copper challenge in a sheep model","volume":"4","author":"Simpson","year":"2004","journal-title":"Proteomics"},{"key":"R34-9-20250207","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1023\/A:1020707811707","article-title":"Oxidative stress\u2010mediated hepatotoxicity of iron and copper: role of Kupffer cells","volume":"16","author":"Videla","year":"2003","journal-title":"Biometals"},{"key":"R35-9-20250207","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/lt.20138","article-title":"A comparison of disease severity and survival rates after liver transplantation in the United Kingdom, Canada, and the United States","volume":"10","author":"Stell","year":"2004","journal-title":"Liver Transpl"},{"key":"R36-9-20250207","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/gast.2003.50016","article-title":"Model for end\u2010stage liver disease (MELD) and allocation of donor livers","volume":"124","author":"Wiesner","year":"2003","journal-title":"Gastroenterology"},{"key":"R37-9-20250207","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/hep.510280320","article-title":"Expression of cyclin\u2010dependent kinase inhibitor p21 in human liver","volume":"28","author":"Crary","year":"1998","journal-title":"HEPATOLOGY"},{"key":"R38-9-20250207","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/1097-0142(20010601)91:11<2096::AID-CNCR1237>3.0.CO;2-9","article-title":"P21WAF1\/CIP1 messenger RNA expression in hepatitis B, C virus\u2010infected human hepatocellular carcinoma tissues","volume":"91","author":"Kobayashi","year":"2001","journal-title":"Cancer"},{"key":"R39-9-20250207","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1023\/A:1011977923941","article-title":"p21WAF1\/CTP1 expression and hepatitis virus type","volume":"46","author":"Wagayama","year":"2001","journal-title":"Dig Dis Sci"},{"key":"R40-9-20250207","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1023\/A:1014472430976","article-title":"Apoptosis and apoptosis related proteins in chronic viral liver disease","volume":"7","author":"Papakyriakou","year":"2002","journal-title":"Apoptosis"},{"key":"R41-9-20250207","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1535-6108(03)00308-8","article-title":"p21Waf1\/Cip1 as a therapeutic target in breast and other cancers","volume":"4","author":"Weiss","year":"2003","journal-title":"Cancer Cell"},{"key":"R42-9-20250207","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0898-6568(00)00081-4","article-title":"The permissive effect of p21(Waf1\/Cip1) on DNA synthesis is dependent on cell type: effect is absent in p53\u2010inactive cells","volume":"12","author":"Weiss","year":"2000","journal-title":"Cell Signal"},{"key":"R43-9-20250207","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1073\/pnas.0307446101","article-title":"Nitric oxide, oxidants, and protein tyrosine nitration","volume":"101","author":"Radi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R44-9-20250207","doi-asserted-by":"crossref","first-page":"13761","DOI":"10.1074\/jbc.M111123200","article-title":"H2O2 induces a transient multi\u2010phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression","volume":"277","author":"Barnouin","year":"2002","journal-title":"J Biol Chem"},{"key":"R45-9-20250207","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0925-4439(02)00225-9","article-title":"Oxidant stress is a significant feature of primary biliary cirrhosis","volume":"1637","author":"Aboutwerat","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"R46-9-20250207","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1191\/0960327102ht213oa","article-title":"Reactive oxygen species as double\u2010edged swords in cellular processes: low\u2010dose cell signaling versus high\u2010dose toxicity","volume":"21","author":"Martin","year":"2002","journal-title":"Hum Exp Toxicol"},{"key":"R47-9-20250207","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/hep.20082","article-title":"Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease","volume":"39","author":"Yang","year":"2004","journal-title":"HEPATOLOGY"},{"key":"R48-9-20250207","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/hep.510250512","article-title":"Expression of alpha\u2010fetoprotein and stem cell factor\/c\u2010kit system in bile duct ligated young rats","volume":"25","author":"Omori","year":"1997","journal-title":"HEPATOLOGY"},{"key":"R50-9-20250207","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.20650","article-title":"Fibrosis correlates with a periportal ductular reaction in chronic hepatitis C: roles of impaired hepatocyte replication, hepatic progenitor cell expansion and steatosis","volume":"41","author":"Clouston","year":"2005","journal-title":"HEPATOLOGY"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.20709","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200506000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T16:07:22Z","timestamp":1738944442000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200506000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.20709","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}