{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:13:43Z","timestamp":1769325223054,"version":"3.49.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3683,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1002\/hep.20803","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T22:46:46Z","timestamp":1121467606000},"page":"335-342","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["rAAV\u2010mediated stable expression of heme oxygenase\u20101 in stellate cells"],"prefix":"10.1097","volume":"42","author":[{"given":"Tung\u2010Yu","family":"Tsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Keung","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Schlitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheung\u2010Tat","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-14-20241104","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"The cellular basis of hepatic fibrosis\u2014mechanisms and treatment strategies","volume":"328","author":"Friedman","year":"1993","journal-title":"N Engl J Med"},{"key":"R2-14-20241104","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/jhep.2003.50127","article-title":"Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal","volume":"37","author":"Bataller","year":"2003","journal-title":"HEPATOLOGY"},{"key":"R3-14-20241104","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1053\/jhep.2003.50118","article-title":"A randomized controlled trial of ursodeoxycholic acid in patients with alcohol\u2010induced cirrhosis and jaundice","volume":"37","author":"Pelletier","year":"2003","journal-title":"HEPATOLOGY"},{"key":"R4-14-20241104","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00042737-200204000-00007","article-title":"Lack of effect of olchicines in alcoholic cirrhosis: final results of a double blind randomized trial","volume":"14","author":"Cortez\u2010Pinto","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R5-14-20241104","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5414\/CPP40002","article-title":"Effects of silymarin MZ\u201080 on oxidative stress in patients with alcoholic cirrhosis. Results of a randomized, double\u2010blind, placebo\u2010controlled clinical study","volume":"40","author":"Lucena","year":"2002","journal-title":"Int J Clin Pharmacol Ther"},{"key":"R6-14-20241104","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/gut.48.6.843","article-title":"Impact of interferon therapy on the natural history of hepatitis C virus related cirrhosis","volume":"48","author":"Gramenzi","year":"2001","journal-title":"Gut"},{"key":"R7-14-20241104","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1053\/gast.2002.36027","article-title":"Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow\u2010up for up to 28 years","volume":"123","author":"Prince","year":"2002","journal-title":"Gastroenterology"},{"key":"R8-14-20241104","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/jhep.2001.20894","article-title":"Transplantation for primary biliary cirrhosis: retrospective analysis of 400 patients in a single center","volume":"33","author":"Liermann Garcia","year":"2001","journal-title":"HEPATOLOGY"},{"key":"R9-14-20241104","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1111\/j.1432-2277.2000.tb02000.x","article-title":"Liver transplantation for alcoholic cirrhosis","volume":"13","author":"Platz","year":"2000","journal-title":"Transpl Int"},{"key":"R10-14-20241104","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1089-3261(05)70113-6","article-title":"The cell and molecular biology of hepatic fibrogenesis: clinical and therapeutic implications","volume":"4","author":"Rockey","year":"2000","journal-title":"Clin Liver Dis"},{"key":"R11-14-20241104","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","article-title":"The heme oxygenase system: a regulator of second messenger gases","volume":"37","author":"Maines","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R12-14-20241104","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/12319","article-title":"Crystal structure of human heme oxygenase\u20101","volume":"6","author":"Schuller","year":"1999","journal-title":"Nat Struct Biol"},{"key":"R13-14-20241104","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1172\/JCI1324","article-title":"Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide\u2010mediated microvascular relaxation","volume":"101","author":"Goda","year":"1998","journal-title":"J Clin Invest"},{"key":"R14-14-20241104","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.510270327","article-title":"Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress\u2010exposed rat liver","volume":"27","author":"Bauer","year":"1998","journal-title":"HEPATOLOGY"},{"key":"R15-14-20241104","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1053\/jhep.2002.33067","article-title":"Extended preservation of rat liver graft by induction of heme oxygenase\u20101","volume":"35","author":"Redaelli","year":"2002","journal-title":"HEPATOLOGY"},{"key":"R16-14-20241104","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1053\/jhep.2003.50300","article-title":"Bilirubin rinse: a simple protectant against the rat liver graft injury mimicking heme oxygenase\u20101 preconditioning","volume":"38","author":"Kato","year":"2003","journal-title":"HEPATOLOGY"},{"key":"R17-14-20241104","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1053\/gast.2001.23249","article-title":"Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin\u2010treated rat liver","volume":"120","author":"Kyokane","year":"2001","journal-title":"Gastroenterology"},{"key":"R18-14-20241104","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1089\/104303402320138970","article-title":"Heme oxygenase 1 gene transfer prevents CD95\/Fas ligand\u2010mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway","volume":"13","author":"Ke","year":"2002","journal-title":"Hum Gene Ther"},{"key":"R19-14-20241104","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1161\/01.CIR.0000066911.03770.8D","article-title":"Prevention of chronic deterioration of heart allograft by recombinant adeno\u2010associated virus\u2010mediated heme oxygenase\u20101 gene transfer","volume":"107","author":"Tsui","year":"2003","journal-title":"Circulation"},{"key":"R20-14-20241104","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1172\/JCI7997","article-title":"Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension","volume":"105","author":"Yu","year":"2000","journal-title":"J Clin Invest"},{"key":"R21-14-20241104","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0016-5085(82)80126-1","article-title":"High yield micronodular cirrhosis in the rat","volume":"83","author":"Proctor","year":"1982","journal-title":"Gastroenterology"},{"key":"R22-14-20241104","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1021\/ac60205a053","article-title":"Two improved and simplified methods for the spectrophotometric determination of hydroxyproline","volume":"35","author":"Bergman","year":"1963","journal-title":"Anal Chem"},{"key":"R23-14-20241104","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1128\/JVI.72.2.1438-1445.1998","article-title":"Membrane\u2010associated heparin sulfate proteoglycan is a receptor for adeno\u2010associated virus type 2 virons","volume":"72","author":"Summerford","year":"1998","journal-title":"J Virol"},{"key":"R24-14-20241104","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/4768","article-title":"\u03b1V\u03b25 integrin: a co\u2010receptor for adeno\u2010associated virus type 2 infection","volume":"5","author":"Summerford","year":"1999","journal-title":"Nat Med"},{"key":"R25-14-20241104","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/4758","article-title":"Human fibroblast growth factor receptor 1 is a co\u2010receptor for infection by adeno\u2010associated virus 2","volume":"5","author":"Qing","year":"1999","journal-title":"Nat Med"},{"key":"R26-14-20241104","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.gt.3300885","article-title":"Reversing liver cirrhosis: impact of gene therapy for liver cirrhosis","volume":"6","author":"Fujimoto","year":"1999","journal-title":"Gene Ther"},{"key":"R27-14-20241104","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/sj.gt.3301109","article-title":"AAV vectors: is clinical success on the horizon?","volume":"7","author":"Monahan","year":"2000","journal-title":"Gene Ther"},{"key":"R28-14-20241104","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/hep.510240310","article-title":"Heparan sulfate proteoglycan expression in chronic cholestatic human liver diseases","volume":"24","author":"Roskams","year":"1996","journal-title":"HEPATOLOGY"},{"key":"R29-14-20241104","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2001-17554","article-title":"Cytokine receptors and signaling in hepatic stellate cells","volume":"21","author":"Pinzani","year":"2001","journal-title":"Semin Liver Dis"},{"key":"R30-14-20241104","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/gast.1996.v110.pm8613002","article-title":"Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells","volume":"110","author":"Carloni","year":"1996","journal-title":"Gastroenterology"},{"key":"R31-14-20241104","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.162250899","article-title":"The atomic structure of adeno\u2010assoicated virus (AAV\u20102), a vector for human gene therapy","volume":"99","author":"Xie","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R32-14-20241104","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","article-title":"Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors","volume":"124","author":"Yang","year":"2003","journal-title":"Gastroenterology"},{"key":"R33-14-20241104","first-page":"802","article-title":"Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus\u2010mediated gene transfer","volume":"3","author":"Guo","year":"1996","journal-title":"Gene Ther"},{"key":"R34-14-20241104","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1128\/JVI.72.1.180-190.1998","article-title":"Reactivation of the previously silenced cytomegalovirus major immediate\u2010early promoter in the mouse liver: involvement of NF\u03baB","volume":"72","author":"L\u00f6ser","year":"1998","journal-title":"J Virol"},{"key":"R35-14-20241104","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1128\/JVI.74.8.3793-3803.2000","article-title":"Nonrandom transduction of recombinant adeno\u2010associated virus vectors in mouse hepatocyte in vivo: cell cycling does not influence hepatocyte trsnduction","volume":"74","author":"Miao","year":"2000","journal-title":"J Virol"},{"key":"R36-14-20241104","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/JVI.78.6.3110-3122.2004","article-title":"Rapid uncoating of vector genome is the key to efficient liver transduction with pseudotyped adeno\u2010associated virus vectors","volume":"78","author":"Thomas","year":"2004","journal-title":"J Virol"},{"key":"R37-14-20241104","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.61.2.748","article-title":"The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase","volume":"61","author":"Tenhunen","year":"1968","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R38-14-20241104","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0006-291X(86)80205-4","article-title":"Characterization of two heme oxygenase isoforms in spleen: comparison with the hematin\u2010induced and constitutive isoforms of the liver","volume":"141","author":"Braggins","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"R39-14-20241104","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0016-5085(03)00906-5","article-title":"Heme oxygeanse\u20101 is an anti\u2010fibrogenic protein in human hepatic myofibrobalsts","volume":"125","author":"Li","year":"2003","journal-title":"Gastroenterology"},{"key":"R40-14-20241104","first-page":"909","article-title":"Heme oxygenase\u20101 and its reaction product, carbon monoxide, prevent inflammation\u2010related apoptotic liver damage in mice","volume":"38","author":"Sass","year":"2003","journal-title":"HEPATOLOGY"},{"key":"R41-14-20241104","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1471-4906(03)00181-9","article-title":"Heme oxygenase\u20101: unleashing the protective properties of heme","volume":"24","author":"Otterbein","year":"2003","journal-title":"Trends Immunol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.20803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200508000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T16:01:11Z","timestamp":1730736071000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200508000-00014"}},"subtitle":["A new approach to attenuate liver fibrosis in rats\u2020"],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.20803","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}