{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:19:32Z","timestamp":1791285572114,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3652,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>\n                                 <jats:bold>The protective effect of dietary saturated fatty acids against the development of alcoholic liver disease has long been known, but the underlying mechanism is not completely understood. We examined the involvement of the adipocyte hormone adiponectin. Circulating adiponectin levels were significantly elevated by chronic ethanol administration to mice consuming a diet high in saturated fat. The increase in circulating adiponectin was associated with the activation a set of hepatic signaling pathways mediated through AMP-activated protein kinase, PPAR-\u03b1, and PPAR-\u03b3 coactivator \u03b1, which in turn led to markedly increased rates of fatty acid oxidation, prevention of hepatic steatosis, and alleviation of liver enzyme changes. Furthermore, treatment of rat 3T3-L1 adipocytes with saturated fatty acids (palmitic or stearic acids) in the presence of ethanol increased secretion of adiponectin and enhanced activity of a mouse adiponectin promoter.<\/jats:bold>\n                                 <jats:underline>In conclusion<\/jats:underline>\n                                 <jats:bold>, the protective action of saturated fat against the development of alcoholic fatty liver in mice is partially mediated through induction of adiponectin. The present findings suggest a novel paradigm for dietary fatty acids in the pathogenesis of alcoholic liver disease and provide a promising therapeutic strategy\u2014nutritional modulation of adiponectin\u2014in treating human alcoholic fatty liver disease. (Hepatology 2005.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.20821","type":"journal-article","created":{"date-parts":[[2005,8,17]],"date-time":"2005-08-17T20:47:19Z","timestamp":1124311639000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":216,"title":["Role of Adiponectin in the Protective Action of Dietary Saturated Fat Against Alcoholic Fatty Liver in Mice * #"],"prefix":"10.1097","volume":"42","author":[{"given":"Min","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"Considine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa C.","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Crabb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-12-20250207","doi-asserted-by":"crossref","first-page":"G382","DOI":"10.1152\/ajpgi.2001.281.2.G382","article-title":"Fatty liver vulnerability to endotoxininduced damage despite NFkappaB induction and inhibited caspase 3 activation.","volume":"281","author":"Yang","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R3-12-20250207","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1530-0277.1989.tb00276.x","article-title":"Beef fat prevents alcoholic liver disease in the rat.","volume":"13","author":"Nanji","year":"1989","journal-title":"Alcohol Clin Exp Res"},{"key":"R4-12-20250207","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/hep.510280401","article-title":"Dietary fat and alcoholic liver disease.","volume":"28","author":"Mezey","year":"1998","journal-title":"Hepatology"},{"key":"R5-12-20250207","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0016-5085(95)90344-5","article-title":"Dietary saturated fatty acids: a novel treatment for alcoholic liver disease.","volume":"109","author":"Nanji","year":"1995","journal-title":"Gastroenterology"},{"key":"R6-12-20250207","first-page":"350","article-title":"Effect of type of dietary fat and ethanol on hepatic leukotriene level in experimental alcoholic liver disease.","volume":"38","author":"Nanji","year":"2003","journal-title":"Nihon Arukoru Yakubutsu Igakkai Zasshi"},{"key":"R7-12-20250207","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/jn\/134.4.904","article-title":"Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition.","volume":"134","author":"Ronis","year":"2004","journal-title":"J Nutr"},{"key":"R8-12-20250207","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/S0022-3565(25)13125-X","article-title":"Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease.","volume":"277","author":"Nanji","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"R9-12-20250207","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-3565(24)29272-7","article-title":"Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration.","volume":"299","author":"Nanji","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"R10-12-20250207","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/hep.510260622","article-title":"Dietary saturated fatty acids downregulate cyclooxygenase2 and tumor necrosis factor alpha and reverse fibrosis in alcoholinduced liver disease in the rat.","volume":"26","author":"Zakim","year":"1997","journal-title":"Hepatology"},{"key":"R11-12-20250207","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.alcohol.2004.08.005","article-title":"Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease.","volume":"34","author":"Nanji","year":"2004","journal-title":"Alcohol"},{"key":"R12-12-20250207","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","article-title":"The role of AMPactivated protein kinase in the action of ethanol in the liver.","volume":"127","author":"You","year":"2004","journal-title":"Gasteroenterology"},{"key":"R13-12-20250207","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1074\/jbc.M008791200","article-title":"The transcriptional and DNA binding activity of peroxisome proliferatoractivated receptor alpha is inhibited by ethanol metabolism. 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