{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:58:16Z","timestamp":1791158296709,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3652,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>\n                                 <jats:bold>Human hepatocarcinoma-intestine-pancreas\/pancreatic-associated protein HIP\/PAP is a secreted C-type lectin belonging to group VII, according to Drickamer's classification. HIP\/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear. In this study, we demonstrate that HIP\/PAP is a paracrine hepatic growth factor promoting both proliferation and viability of liver cells<\/jats:bold>\n                                 <jats:bold>\n                                    in vivo\n                                 <\/jats:bold>\n                                 <jats:bold>. First, a low number of implanted hepatocytes deriving from HIP\/PAP-transgenic mice (&lt;1:1,000) was sufficient to stimulate overall recipient severe combined immunodeficiency liver regeneration after partial hepatectomy. After a single injection of HIP\/PAP protein, the percentages of bromodeoxyuridine-positive nuclei and mitosis were statistically higher than after saline injection, indicating that HIP\/PAP acts as a paracrine mitogenic growth factor for the liver. Comparison of the early events posthepatectomy in control and transgenic mice indicated that HIP\/PAP accelerates the accumulation\/degradation of nuclear phospho\u2013signal transducer activator transcription factor 3 and tumor necrosis factor \u03b1 level, thus reflecting that HIP\/PAP accelerates liver regeneration. Second, we showed that 80% of the HIP\/PAP-transgenic mice versus 25% of the control mice were protected against lethal acetaminophen-induced fulminate hepatitis. A single injection of recombinant HIP\/PAP induced a similar cytoprotective effect, demonstrating the antiapoptotic effect of HIP\/PAP. Comparison of Cu\/Zn superoxide dismutase activity and glutathione reductase-like effects in control and transgenic liver mice indicated that HIP\/PAP exerts an antioxidant activity and prevents reactive oxygen species-induced mitochondrial damage by acetaminophen overdose.<\/jats:bold>\n                                 <jats:underline>In conclusion<\/jats:underline>\n                                 <jats:bold>, the present data offer new insights into the biological functions of C-type lectins. In addition, HIP\/PAP is a promising candidate for the prevention and treatment of liver failure. (Hepatology 2005;42:618\u2013626.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.20845","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T22:19:01Z","timestamp":1124749141000},"page":"618-626","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":70,"title":["HIP\/PAP Accelerates Liver Regeneration and Protects Against Acetaminophen Injury in Mice *"],"prefix":"10.1097","volume":"42","author":[{"given":"Hanh-Tu","family":"Lieu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Batteux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Nicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Zavala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Pauloin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Guilherme","family":"Tralhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Soubrane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Weill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Br\u00e9chot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Christa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20250207","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0959-440X(99)00009-3","article-title":"Ctype lectinlike domains.","volume":"9","author":"Drickamer","year":"1999","journal-title":"Curr Opin Struct Biol"},{"key":"R2-17-20250207","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1016\/S0021-9258(18)47587-4","article-title":"Serum lectin with known structure activates complement through the classical pathway.","volume":"262","author":"Ikeda","year":"1987","journal-title":"J Biol Chem"},{"key":"R3-17-20250207","doi-asserted-by":"crossref","first-page":"12156","DOI":"10.1016\/S0021-9258(19)38325-5","article-title":"Primary structure of the mannose receptor contains multiple motifs resembling carbohydraterecognition domains.","volume":"265","author":"Taylor","year":"1990","journal-title":"J Biol Chem"},{"key":"R4-17-20250207","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-065X.1998.tb01185.x","article-title":"The Ctype lectin superfamily in the immune system.","volume":"163","author":"Weis","year":"1998","journal-title":"Immunol Rev"},{"key":"R5-17-20250207","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/(SICI)1097-0029(19990215)44:4<269::AID-JEMT6>3.0.CO;2-K","article-title":"Cell adhesion in the process of asexual reproduction of tunicates.","volume":"44","author":"Kawamura","year":"1999","journal-title":"Microsc Res Tech"},{"key":"R6-17-20250207","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.virol.2004.05.019","article-title":"The Ctype lectin homologue gene (EP153R) of African swine fever virus inhibits apoptosis both in virus infection and in heterologous expression.","volume":"326","author":"Hurtado","year":"2004","journal-title":"Virology"},{"key":"R7-17-20250207","first-page":"5089","article-title":"A novel gene (HIP) activated in human primary liver cancer.","volume":"52","author":"Lasserre","year":"1992","journal-title":"Cancer Res"},{"key":"R8-17-20250207","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1172\/JCI116115","article-title":"Human pancreatitisassociated protein. 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