{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:41:15Z","timestamp":1791740475543,"version":"4.3.4"},"reference-count":194,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3499,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:bold>Death of hepatocytes and other hepatic cell types is a characteristic feature of liver diseases as diverse as cholestasis, viral hepatitis, ischemia\/reperfusion, liver preservation for transplantation and drug\/toxicant-induced injury. Cell death typically follows one of two patterns: oncotic necrosis and apoptosis. Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia\/reperfusion and acute drug-induced hepatotoxicity. Apoptosis, in contrast, represents the execution of an ATP-dependent death program often initiated by death ligand\/death receptor interactions, such as Fas ligand with Fas, which leads to a caspase activation cascade. A common event leading to both apoptosis and necrosis is mitochondrial permeabilization and dysfunction, although the mechanistic basis of mitochondrial injury may vary in different settings. Prevention of these modes of cell death is an important target of therapy, but controversies still exist regarding which mode of cell death predominates in various forms of liver disease and injury. Resolution of these controversies may come with the recognition that apoptosis and necrosis frequently represent alternate outcomes of the same cellular pathways to cell death, especially for cell death mediated by mitochondrial permeabilization. An understanding of processes leading to liver cell death will be important for development of effective interventions to prevent hepatocellular death leading to liver failure and to promote cancer and stellate cell death in malignancy and fibrotic disease.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.21062","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T19:16:42Z","timestamp":1138648602000},"page":"S31-S44","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":572,"title":["Apoptosis and Necrosis in the Liver: A Tale of Two Deaths?"],"prefix":"10.1097","volume":"43","author":[{"given":"Harmeet","family":"Malhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Gores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Lemasters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20241202","first-page":"3","article-title":"Apoptosis, oncosis, and necrosis. 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study","volume":"21","author":"Zahrebelski","year":"1995","journal-title":"Hepatology"},{"key":"R13-2-20241202","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1096\/fasebj.2.2.3342967","article-title":"Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability","volume":"2","author":"Herman","year":"1988","journal-title":"FASEB J"},{"key":"R14-2-20241202","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0143-4160(88)90004-8","article-title":"Calcium dependence of bleb formation and cell death in hepatocytes","volume":"9","author":"Nieminen","year":"1988","journal-title":"Cell Calcium"},{"key":"R15-2-20241202","first-page":"657","article-title":"Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine","volume":"78","author":"Dong","year":"1998","journal-title":"Lab 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