{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:06:01Z","timestamp":1768442761799,"version":"3.49.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3287,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,9]]},"abstract":"\n \n \n Twin and family studies suggest there is a significant genetic component to primary biliary cirrhosis (PBC). However, the inability to replicate reported associations has been a recurring problem, with the only consistently reported genetic association that between PBC and HLA<\/jats:bold>-\n DRB1*0801\n <\/jats:bold>\n . However, recently even this has been questioned, and a number of novel associations have also been reported. We reinvestigated HLA class II<\/jats:bold>\n \n DRB1, DQA1,\n <\/jats:bold>\n and<\/jats:bold>\n \n DQB1\n <\/jats:bold>\n alleles and haplotypes in a total of 492 well-characterized PBC patients, 412 from the United Kingdom and an additional 80 patients from northern Italy. There was a clear and significant association with HLA<\/jats:bold>\n \n -DRB1*0801\n <\/jats:bold>\n in both groups of patients compared to population-specific healthy controls (12% versus 4% in the UK patients,<\/jats:bold>\n \n P\n <\/jats:bold>\n = .00087, OR = 3.05; and 18% versus 6% in the Italian patients,<\/jats:bold>\n \n P\n <\/jats:bold>\n = .021, OR = 3.15). There were also significant protective associations with<\/jats:bold>\n \n DRB1*11\n <\/jats:bold>\n in the Italian patients (28% versus 47%,<\/jats:bold>\n \n P\n <\/jats:bold>\n = .0071, OR = 0.42), but not in the UK patients (8% versus 8%) and a protective association with<\/jats:bold>\n \n DRB1*13\n <\/jats:bold>\n in both series (14% versus 20%,<\/jats:bold>\n \n P\n <\/jats:bold>\n = .042, OR = 0.65 in the UK patients; and 10% versus 31%,<\/jats:bold>\n \n P\n <\/jats:bold>\n = .00092, OR = 0.25 in the Italian patients).<\/jats:bold>\n \n In conclusion\n <\/jats:bold>\n , a complex relationship exists between HLA and PBC, and some genetic associations may be population specific.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.21316","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T02:07:06Z","timestamp":1156903626000},"page":"667-674","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":120,"title":["HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: A large-scale study"],"prefix":"10.1097","volume":"44","author":[{"given":"Peter T.","family":"Donaldson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Baragiotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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