{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:35:23Z","timestamp":1770824123686,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3226,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Biliary atresia is an inflammatory fibrosclerosing lesion of the bile ducts that leads to biliary cirrhosis and is the most frequent indication for liver transplantation in children. The pathogenesis of biliary atresia is not known; one theory is that of a virus-induced, subsequent autoimmune-mediated injury of bile ducts. The aim of this study was to determine whether autoreactive T cells and autoantibodies specific to bile duct epithelia are present in the rotavirus (RRV)- induced murine model of biliary atresia and whether the T cells are sufficient to result in bile duct inflammation.<\/jats:bold>\n                                 <jats:bold>\n                                    In vitro\n                                 <\/jats:bold>\n                                 <jats:bold>analyses showed significant increases in IFN-\u03b3\u2013producing T cells from RRV-diseased mice in response to bile duct epithelial autoantigen. Adoptive transfer of the T cells from RRV-diseased mice into na\u00efve syngeneic SCID recipients resulted in bile duct\u2013specific inflammation. This induction of bile duct pathology occurred in the absence of detectable virus, indicating a definite response to bile duct autoantigens. Furthermore, periductal immunoglobulin deposits and serum antibodies reactive to bile duct epithelial protein were detected in RRV-diseased mice.<\/jats:bold>\n                                 <jats:bold>\n                                    In conclusion,\n                                 <\/jats:bold>\n                                 <jats:bold>both cellular and humoral components of autoimmunity exist in murine biliary atresia, and the progressive bile duct injury is due in part to a bile duct epithelia\u2013specific T cell\u2013mediated immune response. The role of cellular and humoral autoimmunity in human biliary atresia and possible interventional strategies therefore should be the focus of future research.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.21366","type":"journal-article","created":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T19:24:27Z","timestamp":1161372267000},"page":"1231-1239","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":111,"title":["Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia"],"prefix":"10.1097","volume":"44","author":[{"given":"Cara L.","family":"Mack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandy R.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Fontenot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald G.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-18-20241201","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1203\/01.PDR.0000130480.51066.FB","article-title":"Biliary atresia is associated with CD4 Th1 cellmediated portal tract inflammation.","volume":"56","author":"Mack","year":"2004","journal-title":"Pediatr Res"},{"key":"R2-18-20241201","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1053\/jpsu.2001.24730","article-title":"Immunohistochemistry of the liver and biliary tree in extrahepatic biliary atresia.","volume":"36","author":"Davenport","year":"2001","journal-title":"J Pediatr Surg"},{"key":"R3-18-20241201","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0022-3468(96)90333-4","article-title":"The inflammatory response in pediatric biliary disease: macrophage phenotype and distribution.","volume":"31","author":"Tracy","year":"1996","journal-title":"J Pediatr Surg"},{"key":"R4-18-20241201","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0022-3468(97)90714-4","article-title":"Hepatic overexpression of MHC class II antigens and macrophageassociated antigens (CD68) in patients with biliary atresia of poor prognosis.","volume":"32","author":"Kobayashi","year":"1997","journal-title":"J Pediatr Surg"},{"key":"R5-18-20241201","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/archsurg.1996.01430170039006","article-title":"Longterm results with the Kasai operation for biliary atresia.","volume":"131","author":"Karrer","year":"1996","journal-title":"Arch Surg"},{"key":"R6-18-20241201","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.20547","article-title":"Outcome in adulthood of biliary atresia: a study of 63 patients who survived for over 20 years with their native liver.","volume":"41","author":"Lykavieris","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R7-18-20241201","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0022-3468(94)90377-8","article-title":"Extrahepatic biliary atresia: a first trimester event? 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