{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:30:05Z","timestamp":1791088205082,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3226,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:bold>Liver fatty acid\u2013binding protein (L-Fabp) regulates murine hepatic fatty acid trafficking in response to fasting. In this study, we show that L-Fabp\u2212\/\u2212 mice fed a high-fat Western diet for up to 18 weeks are less obese and accumulate less hepatic triglyceride than C57BL\/6J controls. Paradoxically, both control and L-Fabp\u2212\/\u2212 mice manifested comparable glucose intolerance and insulin resistance when fed a Western diet. Protection against obesity in Western diet\u2013fed L-Fabp\u2212\/\u2212 mice was not due to discernable changes in food intake, fat malabsorption, or heat production, although intestinal lipid secretion kinetics were significantly slower in both chow-fed and Western diet\u2013fed L-Fabp\u2212\/\u2212 mice. By contrast, there was a significant increase in the respiratory exchange ratio in L-Fabp\u2212\/\u2212 mice, suggesting a shift in energy substrate use from fat to carbohydrate, findings supported by an approximately threefold increase in serum lactate. Microarray analysis revealed increased expression of genes involved in lipid synthesis (fatty acid synthase, squalene epoxidase, hydroxy-methylglutaryl coenzyme A reductase), while genes involved in glycolysis (glucokinase and glycerol kinase) were decreased in L-Fabp\u2212\/\u2212 mice. Fatty acid synthase expression was also increased in the skeletal muscle of L-Fabp\u2212\/\u2212 mice.<\/jats:bold>\n                      <jats:bold>In conclusion<\/jats:bold>\n                      <jats:bold>, L-Fabp may function as a metabolic sensor in regulating lipid homeostasis. We suggest that L-Fabp\u2212\/\u2212 mice are protected against Western diet\u2013induced obesity and hepatic steatosis through a series of adaptations in both hepatic and extrahepatic energy substrate use.<\/jats:bold>\n                      <jats:bold>Supplementary material for this article can be found on the HEPATOLOGY website<\/jats:bold>\n                      (http:\/\/interscience.wiley.com\/jpages\/0270-9139\/suppmat\/index.html).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.21369","type":"journal-article","created":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T15:16:54Z","timestamp":1161357414000},"page":"1191-1205","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":179,"title":["Protection against Western diet\u2013induced obesity and hepatic steatosis in liver fatty acid\u2013binding protein knockout mice"],"prefix":"10.1097","volume":"44","author":[{"given":"Elizabeth P.","family":"Newberry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas O.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20241201","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.2337\/diabetes.54.12.3458","article-title":"Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factorkappaB pathway in rat liver.","volume":"54","author":"Boden","year":"2005","journal-title":"Diabetes"},{"key":"R2-15-20241201","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2174\/1566524053766031","article-title":"The fatty liver and insulin resistance.","volume":"5","author":"YkiJarvinen","year":"2005","journal-title":"Curr Mol Med"},{"key":"R3-15-20241201","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/01.ATV.0000116217.57583.6e","article-title":"Hepatic steatosis: a mediator of the metabolic syndrome. 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