{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:11:10Z","timestamp":1791033070195,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3106,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Hepatocyte function and regeneration are severely compromised in severe liver disease, and a common sequela is cirrhosis. Structural changes caused by cirrhosis create a cellular environment conducive to the formation of ductular reactions (DRs). Ductular reactions are primarily composed of oval cells also known as \u201cintermediate hepatobiliary cells\u201d. We have conducted single, double, and triple staining to study lineages of oval cells present in DRs. Staining with NCAM, CK19, and HepPar1 has revealed a distinctly bipolar structure to DRs that are embedded in cirrhotic tissue. Spatial analysis of cells that are singly HepPar1-positive, or CK19-positive, has revealed hepatocytic and biliary poles, respectively, in the DRs. Also, the location of singly NCAM-positive cells in DRs suggests that they may be bipotent liver stem\/progenitor cells. The locations of other intermediate hepatobiliary cells, which have combinations of markers, suggest that CK19+\/NCAM+ cells are transitional cells in the biliary lineage and that rare cells that are negative for all three markers are transitional cells in the hepatocytic lineage. A working cell lineage model for DRs is presented. (Hepatology 2007;45:716\u2013724.)<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.21557","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T17:07:31Z","timestamp":1172509651000},"page":"716-724","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":124,"title":["Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver"],"prefix":"10.1097","volume":"45","author":[{"given":"Hongchao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie E.","family":"Rogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Teperman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Rogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20241201","first-page":"142","article-title":"Similarities in the sequence of early histologic changes induced in the liver of the rat by ethionine, 2acetylaminoflluorene, and 3methyl4dimethylaminoazobenzene.","volume":"16","author":"Farber","year":"1956","journal-title":"Cancer Res"},{"key":"R2-19-20241201","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/carcin\/2.1.7","article-title":"Autoradiagraphy of oval cells appearing rapidly in the livers of rats fed N2 flluorenylacetamide in a cholinedevoid diet.","volume":"2","author":"Sell","year":"1981","journal-title":"Carcinogenesis"},{"key":"R3-19-20241201","first-page":"1761","article-title":"Comparison of oval cells induced in rat liver by feeding N2lllFluorenylacetamide in a cholinedevoid diet and bile duct cells induced by feeding 4,4 diaminodiphpenylmethane.","volume":"43","author":"Sell","year":"1983","journal-title":"Cancer Res"},{"key":"R4-19-20241201","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/carcin\/8.11.1737","article-title":"A precursorproduct relationship exists between oval cells and hepatocytes in rat liver.","volume":"8","author":"Evarts","year":"1987","journal-title":"Carcinogenesis"},{"key":"R5-19-20241201","first-page":"218","article-title":"Connection of ductlike structures induced by chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.","volume":"118","author":"Dunford","year":"1985","journal-title":"Am J Pathol"},{"key":"R6-19-20241201","first-page":"4887","article-title":"Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.","volume":"49","author":"Dunsford","year":"1989","journal-title":"Cancer Res"},{"key":"R7-19-20241201","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00007890-198907000-00021","article-title":"Selective proliferation of chemically altered rat liver epithelial cells following hepatic transplantation.","volume":"48","author":"Faris","year":"1989","journal-title":"Transplantation"},{"key":"R8-19-20241201","first-page":"535","article-title":"Oval cell proliferation and the origin of small hepatocytes in liver injury induced by Dgalactosamine. 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