{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:50:20Z","timestamp":1782924620594,"version":"3.54.5"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2953,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1002\/hep.21680","type":"journal-article","created":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T21:50:27Z","timestamp":1185313827000},"page":"528-534","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":104,"title":["A modified international normalized ratio as an effective way of prothrombin time standardization in hepatology\u2020"],"prefix":"10.1097","volume":"46","author":[{"given":"Laurent","family":"Bellest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Eschw\u00e8ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Poupon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chazouill\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-31-20241201","doi-asserted-by":"crossref","first-page":"457S","DOI":"10.1378\/chest.126.3_suppl.204S","article-title":"The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Ansell","year":"2004","journal-title":"Chest"},{"key":"R2-31-20241201","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1093\/clinchem\/46.12.2027","article-title":"Diagnosis and monitoring of hepatic injury. II. Recommendation for use of laboratory tests in screening, diagnosis, and monitoring","volume":"46","author":"Dufour","year":"2000","journal-title":"Clin Chem"},{"key":"R3-31-20241201","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-0038-1648029","article-title":"Reference method for the one\u2010stage prothrombin\u2010time in human blood","volume":"36","author":"Ingram","year":"1976","journal-title":"Thromb Haemost"},{"key":"R4-31-20241201","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1055\/s-0038-1657009","article-title":"The optimal therapeutic range in oral anticoagulation: history and proposal","volume":"42","author":"Loeliger","year":"1979","journal-title":"Thromb Haemost"},{"key":"R5-31-20241201","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2141.1982.00479.x","article-title":"Dosage and control of oral anticoagulants: an international survey","volume":"51","author":"Poller","year":"1982","journal-title":"Br J Haematol"},{"key":"R6-31-20241201","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198212303072704","article-title":"Different intensities of oral anticoagulant therapy in the treatment of proximal\u2010vein thrombosis","volume":"307","author":"Hull","year":"1982","journal-title":"N Engl J Med"},{"key":"R8-31-20241201","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1538-7836.2004.00775.x","article-title":"International normalized ratios (INR): the first 20 years","volume":"2","author":"Poller","year":"2004","journal-title":"J Thromb Haemost"},{"key":"R9-31-20241201","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0016-5085(16)34599-1","article-title":"Prothrombin time in fulminant hepatic failure","volume":"100","author":"Munoz","year":"1991","journal-title":"Gastroenterology"},{"key":"R10-31-20241201","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/hep.510240613","article-title":"Prothrombin time in liver failure: time, ratio, activity percentage,or international ratio?","volume":"24","author":"Robert","year":"1996","journal-title":"HEPATOLOGY"},{"key":"R11-31-20241201","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.20703","article-title":"AASLD position paper: the management of acute liver failure","volume":"41","author":"Polson","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R12-31-20241201","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/hep.20772","article-title":"Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT\u2010C cohort","volume":"42","author":"Lok","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R13-31-20241201","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"HEPATOLOGY"},{"key":"R14-31-20241201","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with end\u2010stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"HEPATOLOGY"},{"key":"R15-31-20241201","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/gast.2003.50016","article-title":"United Network for Organ Sharing Liver Disease Severity Score Committee: model for end\u2010stage liver disease (MELD) and allocation of donor livers","volume":"124","author":"Wiesner","year":"2003","journal-title":"Gastroenterology"},{"key":"R16-31-20241201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.20704","article-title":"AASLD practice guidelines: evaluation of the patient for liver transplantation","volume":"41","author":"Murray","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R17-31-20241201","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1055\/s-0038-1642513","article-title":"Assessment of the validity of the INR system for patients with liver impairment","volume":"71","author":"Kovaks","year":"1994","journal-title":"Thromb Haemost"},{"key":"R18-31-20241201","first-page":"162","article-title":"Validity of the INR system for patients with liver impairment","volume":"713","author":"Denson","year":"1995","journal-title":"Thromb Haemost"},{"key":"R19-31-20241201","first-page":"279","article-title":"Rabbit brain\u2010derived thromboplastins do not yield equivalent INRs for patients with liver impairment","volume":"3","author":"Kovacs","year":"1997","journal-title":"Lab Hematol"},{"key":"R20-31-20241201","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/lt.20195","article-title":"Specific laboratory methodologies achieve higher model for endstage liver disease (MELD) scores for patients listed for liver transplantation","volume":"10","author":"Trotter","year":"2004","journal-title":"Liver Transpl"},{"key":"R21-31-20241201","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1093\/clinchem\/46.12.2027","article-title":"Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests","volume":"46","author":"Dufour","year":"2000","journal-title":"Clin Chem"},{"key":"R22-31-20241201","first-page":"64","article-title":"Guidelines for thromboplastins and plasma used to control anticoagulant therapy.","volume":"889","year":"1999","journal-title":"WHO Technical Report Series"},{"key":"R23-31-20241201","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1111\/j.1538-7836.2004.00970.x","article-title":"Guidelines on preparation, certification, and use of certified plasmas for ISI calibration and INR determination","volume":"2","author":"van den Besselaar","year":"2004","journal-title":"J Thromb Haemost"},{"key":"R24-31-20241201","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"R25-31-20241201","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/200589a0","article-title":"Nature of prothrombin biosynthesis: preprothrombinaemia in vitamin deficiency","volume":"200","author":"Hemker","year":"1963","journal-title":"Nature"},{"key":"R26-31-20241201","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-0038-1650178","article-title":"The inhibitor of prothrombin conversion in plasma of patients on oral anticoagulant treatment","volume":"45","author":"Bertina","year":"1981","journal-title":"Thromb Haemost"},{"key":"R27-31-20241201","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0140-6736(02)07282-3","article-title":"Interpretation of the international normalised ratio in patients with liver disease","volume":"359","author":"Deitcher","year":"2002","journal-title":"Lancet"},{"key":"R28-31-20241201","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0049-3848(98)00217-5","article-title":"Comparative studies of rabbit and human recombinant tissue factor reagents","volume":"94","author":"Denson","year":"1999","journal-title":"Thromb Res"},{"key":"R29-31-20241201","first-page":"633","article-title":"Monitoring oral anticoagulant treatment from plasma stored for up to 48 hours and frozen plasma","volume":"84","author":"Grau","year":"1999","journal-title":"Haematologica"},{"key":"R30-31-20241201","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00001721-200106000-00002","article-title":"Stability of coagulation proteins in frozen plasma","volume":"12","author":"Woodhams","year":"2001","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R31-31-20241201","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1055\/s-0037-1614420","article-title":"Influence of three types of automated coagulometers on the international sensitivity index (ISI) of rabbit, human, and recombinant human tissue factor preparations: a multicenter study","volume":"81","author":"van den Besselaar","year":"1999","journal-title":"Thromb Haemost"},{"key":"R32-31-20241201","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1111\/j.1600-6143.2006.01508.x","article-title":"Geographic differences in event rates by model for end\u2010stage liver disease score","volume":"6","author":"Roberts","year":"2006","journal-title":"Am J Transplant"},{"key":"R33-31-20241201","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1097\/00003246-200111000-00007","article-title":"Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo\u2010controlled, single\u2010blind, dose escalation study","volume":"29","author":"Abraham","year":"2001","journal-title":"Crit Care Med"},{"key":"R34-31-20241201","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1097\/01.CCM.0000166928.68628.41","article-title":"The prothrombin time point of the disseminated intravascular coagulation score","volume":"33","author":"Kountchev","year":"2005","journal-title":"Crit Care Med"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.21680","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200708000-00031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T13:36:12Z","timestamp":1733060172000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200708000-00031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.21680","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}