{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:56:31Z","timestamp":1791356191925,"version":"4.3.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2831,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"INSERM AVENIR"},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer (ARC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universit\u00e9 Paris-Sud (Bonus Qualit\u00e9 Recherche)"},{"name":"National French Society of Gastroenterology (SNFGE)"},{"name":"Institut de Recherche sur les Boissons (IREB)"},{"name":"European Union FP6 (INNOCHEM)","award":["LSHB-CT-2005-518167"],"award-info":[{"award-number":["LSHB-CT-2005-518167"]}]},{"name":"Fellowships from ARC"},{"name":"Fellowships from INSERM, Ile de France"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Glucocorticoid-induced leucine zipper (GILZ), a recently identified protein induced by glucocorticoids (GCs), inhibits the nuclear factor \u03baB pathway and the activation of monocytes\/macrophages by lipopolysaccharides (LPS). This study aimed to elucidate the contribution of GILZ to the pathogenesis of alcoholic hepatitis (AH): we (1) assessed<\/jats:bold>\n                                 <jats:bold>\n                                    GILZ\n                                 <\/jats:bold>\n                                 <jats:bold>expression in the livers of patients with AH and (2) treated patients with severe AH with GCs (prednisolone 40 mg\/day) and studied the effect of GILZ modulation on circulating monocyte function. We quantified<\/jats:bold>\n                                 <jats:bold>\n                                    GILZ\n                                 <\/jats:bold>\n                                 <jats:bold>expression in the livers of 42 consecutive alcoholic patients (21 with and 21 without AH). GILZ messenger RNA (mRNA) levels were lower in the livers of patients with AH versus those without AH (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&lt; 0.05). We collected circulating monocytes from patients with severe AH before and 48 hours after GC treatment to quantify<\/jats:bold>\n                                 <jats:bold>\n                                    GILZ\n                                 <\/jats:bold>\n                                 <jats:bold>expression and cytokine secretion. GC treatment induced significantly higher levels of GILZ mRNA than that observed before treatment and impaired LPS-induced tumor necrosis factor-\u03b1 (TNF-\u03b1) and regulated upon activation, normal T cell\u2013expressed secretion (RANTES) by these monocytes. We transfected circulating monocytes with GILZ small interfering RNA (siRNA), specifically blocking<\/jats:bold>\n                                 <jats:bold>\n                                    GILZ\n                                 <\/jats:bold>\n                                 <jats:bold>expression, to demonstrate the role of GILZ in mediating GC effect. GILZ siRNA abrogated the effect of GC treatment on LPS-induced TNF-\u03b1 and RANTES secretion.<\/jats:bold>\n                                 <jats:bold>\n                                    Conclusion:\n                                 <\/jats:bold>\n                                 <jats:bold>Low expression of<\/jats:bold>\n                                 <jats:bold>\n                                    GILZ\n                                 <\/jats:bold>\n                                 <jats:bold>may contribute to liver inflammation in AH. GCs enhance<\/jats:bold>\n                                 <jats:bold>\n                                    GILZ\n                                 <\/jats:bold>\n                                 <jats:bold>expression, abrogating macrophage sensitivity to LPS and proinflammatory cytokine secretion. These findings may explain the beneficial effect of GC treatment in patients with severe AH. (Hepatology 2007;46:1986\u20131992.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.21880","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T16:47:41Z","timestamp":1196268461000},"page":"1986-1992","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":49,"title":["Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis"],"prefix":"10.1097","volume":"46","author":[{"given":"Haifa","family":"Hamdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Bigorgne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Naveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Balian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bouchet-Delbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Cassard-Doulcier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Maillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Durand-Gasselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pr\u00e9vot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Delaveaucoupet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Emilie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Perlemuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-37-20241201","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-2007-1007110","article-title":"Cytokines 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