{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:31:23Z","timestamp":1792168283264,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2831,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Elderly liver donors (ELDs) represent a possible expansion of the donor pool, although there is great reluctance to use ELDs because of reports that increasing donor age predicts graft loss and patient death. The goal of this study was to identify a subgroup of recipients who would be least affected by increased donor age and thus best suited to receive grafts from ELDs. A national registry of deceased donor liver transplants from 2002\u20132005 was analyzed. ELDs aged 70\u201392 (n = 1043) were compared with average liver donors (ALDs) aged 18\u201369 (n = 15,878) and ideal liver donors (ILDs) aged 18\u201339 (n = 6842). Recipient factors that modified the effect of donor age on outcomes were identified via interaction term analysis. Outcomes in recipient subgroups were compared using Kaplan-Meier survival analysis. Recipients preferred for ELD transplants were determined to be first-time recipients over the age of 45 with body mass index &lt;35, non\u2013status 1 registration, cold ischemic time &lt;8 hours, and either hepatocellular carcinoma or an indication for transplantation other than hepatitis C. In preferred recipients, there were no differences in outcomes when ELD livers were used (3-year graft survival: ELD 75%, ALD 75%, ILD 77%,<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&gt; 0.1; 3-year patient survival: ELD 81%, ALD 80%, ILD 81%,<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&gt; 0.1). In contrast, there were significantly worse outcomes when ELD livers were used in nonpreferred recipients (3-year graft survival: ELD 50%, ALD 71%, ILD 75%,<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&lt; 0.001; 3-year patient survival: ELD 64%, ALD 77%, ILD 80%,<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&lt; 0.001).<\/jats:bold>\n                                 <jats:bold>\n                                    Conclusion:\n                                 <\/jats:bold>\n                                 <jats:bold>The risks of ELDs can be substantially minimized by appropriate recipient selection. (Hepatology 2007.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.21888","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T20:46:37Z","timestamp":1191530797000},"page":"1907-1918","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":87,"title":["Minimizing risk associated with elderly liver donors by matching to preferred recipients"],"prefix":"10.1097","volume":"46","author":[{"given":"Dorry L.","family":"Segev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren R.","family":"Maley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Simpkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayme E.","family":"Locke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey C.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Thuluvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-29-20241201","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/jlts.2003.50105","article-title":"The utility of marginal donors in liver transplantation.","volume":"9","author":"Busuttil","year":"2003","journal-title":"Liver Transpl"},{"key":"R3-29-20241201","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/lt.20304","article-title":"Expanded criteria donor grafts for deceased donor liver transplantation under the MELD system: a decision analysis.","volume":"10","author":"Amin","year":"2004","journal-title":"Liver Transpl"},{"key":"R5-29-20241201","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1016\/j.transproceed.2005.08.050","article-title":"Analysis of discarded livers for transplantation.","volume":"37","author":"Escartin","year":"2005","journal-title":"Transplant Proc"},{"key":"R6-29-20241201","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-6143.2006.01600.x","article-title":"Nontransplantation of livers from deceased donors who are able to donate another solid organ: how often and why it happens.","volume":"7","author":"Sayuk","year":"2007","journal-title":"Am J Transplant"},{"key":"R7-29-20241201","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1097\/00007890-200106270-00011","article-title":"The impact of donor age on liver transplantation: influence of donor age on early liver function and on subsequent patient and graft survival.","volume":"71","author":"Busquets","year":"2001","journal-title":"Transplantation"},{"key":"R8-29-20241201","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/jlts.2003.50050","article-title":"Evaluation of potential liver donors: limits imposed by donor variables in liver transplantation.","volume":"9","author":"Rull","year":"2003","journal-title":"Liver Transpl"},{"key":"R9-29-20241201","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/152692480601600112","article-title":"Liver transplantation in Italy: analysis of risk factors associated with graft outcome.","volume":"16","author":"Quintieri","year":"2006","journal-title":"Prog Transplant"},{"key":"R10-29-20241201","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1016\/j.transproceed.2005.06.056","article-title":"Using elderly donors in liver transplantation.","volume":"37","author":"Grazi","year":"2005","journal-title":"Transplant 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years.","volume":"62","author":"Emre","year":"1996","journal-title":"Transplantation"},{"key":"R17-29-20241201","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1053\/jlts.2003.50234","article-title":"Longterm survival of recipients of liver grafts from donors older than 80 years: is it achievable?","volume":"9","author":"Cescon","year":"2003","journal-title":"Liver Transpl"},{"key":"R18-29-20241201","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/00007890-199908270-00021","article-title":"Use of octogenarian livers safely expands the donor pool.","volume":"68","author":"Jimenez Romero","year":"1999","journal-title":"Transplantation"},{"key":"R19-29-20241201","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.transproceed.2004.11.056","article-title":"Does the liver ever age? Results of liver transplantation with donors above 80 years of age.","volume":"37","author":"Zapletal","year":"2005","journal-title":"Transplant Proc"},{"key":"R20-29-20241201","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1016\/j.transproceed.2005.10.040","article-title":"Donors older than 70 years in liver transplantation.","volume":"37","author":"Gastaca","year":"2005","journal-title":"Transplant Proc"},{"key":"R21-29-20241201","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1432-2277.2005.00128.x","article-title":"Older liver graft transplantation, cholestasis and synthetic graft function.","volume":"18","author":"Borchert","year":"2005","journal-title":"Transpl Int"},{"key":"R22-29-20241201","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.transproceed.2004.12.261","article-title":"Adult liver transplantation using liver grafts from donors over 70 years of 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