{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:40:10Z","timestamp":1792518010602,"version":"4.5.0"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2800,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Potential functional roles for the peroxisome proliferator-activated receptor-\u03b2\/\u03b4 (PPAR\u03b2\/\u03b4) in skeletal muscle fatty acid catabolism and epithelial carcinogenesis have recently been described. Whereas PPAR\u03b2\/\u03b4 is expressed in liver, its function in this tissue is less clear. To determine the role of PPAR\u03b2\/\u03b4 in chemically induced liver toxicity, wild-type and PPAR\u03b2\/\u03b4-null mice were treated with azoxymethane (AOM) and markers of liver toxicity examined. Bile duct hyperplasia, regenerative hyperplasia, and increased serum alanine aminotransferase (ALT) were found in AOM-treated PPAR\u03b2\/\u03b4-null mice, and these effects were not observed in similarly treated wild-type mice. Exacerbated carbon tetrachloride (CCl4) hepatoxicity was also observed in PPAR\u03b2\/\u03b4-null as compared with wild-type mice. No differences in messenger RNAs (mRNAs) encoding cytochrome2E1 required for the metabolic activation of AOM and CCl4 were observed between wild-type or PPAR\u03b2\/\u03b4-null mice in response to CCl4. Significant differences in the expression of genes reflecting enhanced nuclear factor kappa B (NF-\u03baB) activity were noted in PPAR\u03b2\/\u03b4-null mice.<\/jats:bold>\n                                 <jats:bold>\n                                    Conclusion:\n                                 <\/jats:bold>\n                                 <jats:bold>Results from these studies show that PPAR\u03b2\/\u03b4 is protective against liver toxicity induced by AOM and CCl4, suggesting that this receptor is hepatoprotective against environmental chemicals that are metabolized in this tissue. (Hepatology 2007.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.21925","type":"journal-article","created":{"date-parts":[[2007,11,25]],"date-time":"2007-11-25T21:46:34Z","timestamp":1196027194000},"page":"225-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":84,"title":["Peroxisome proliferator-activated receptor-\u03b2\/\u03b4 protects against chemically induced liver toxicity in mice"],"prefix":"10.1097","volume":"47","author":[{"given":"Weiwei","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses 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