{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:28:22Z","timestamp":1788683302329,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2769,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:bold>Liver transplantation in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is a recent indication. In a single center, we have compared the survival and severity of recurrent HCV infection after liver transplantation in HIV-HCV\u2013coinfected and HCV-monoinfected patients. Seventy-nine patients receiving a first liver graft for HCV-related liver disease between 1999 and 2005 were included. Among them, 35 had highly active antiretroviral therapy\u2013controlled HIV infection. All patients were monitored for HCV viral load and liver histology during the posttransplantation course. Coinfected patients were younger (43 \u00b1 6 versus 55 \u00b1 8 years,<\/jats:bold>\n                      <jats:bold>P<\/jats:bold>\n                      <jats:bold>&lt; 0.0001) and had a higher Model for End-Stage Liver Disease (MELD) score (18.8 \u00b1 7.4 versus 14.8 \u00b1 4.7;<\/jats:bold>\n                      <jats:bold>P<\/jats:bold>\n                      <jats:bold>= 0.008). The 2-year and 5-year survival rates were 73% and 51% and 91% and 81% in coinfected patients and monoinfected patients, respectively (log-rank<\/jats:bold>\n                      <jats:bold>P<\/jats:bold>\n                      <jats:bold>= 0.004). Under multivariate Cox analysis, survival was related only to the MELD score (<\/jats:bold>\n                      <jats:bold>P<\/jats:bold>\n                      <jats:bold>= 0.03; risk ratio, 1.08; 95% confidence interval, 1.01, 1.15). Using the Kaplan-Meier method, the progression to fibrosis \u2265 F2 was significantly higher in the coinfected group (<\/jats:bold>\n                      <jats:bold>P<\/jats:bold>\n                      <jats:bold>&lt; 0.0001).<\/jats:bold>\n                      <jats:bold>Conclusion:<\/jats:bold>\n                      <jats:bold>The results of liver transplantation in HIV-HCV\u2013coinfected patients were satisfactory in terms of survival benefit. Earlier referral of these patients to a liver transplant unit, the use of new drugs effective against HCV, and an avoidance of drug toxicity are mandatory if we are to improve the results of this challenging indication for liver transplantation. (Hepatology 2007.)<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.21990","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T18:50:02Z","timestamp":1198176602000},"page":"407-417","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":157,"title":["Survival and recurrence of hepatitis C after liver transplantation in patients coinfected with human immunodeficiency virus and hepatitis C virus"],"prefix":"10.1097","volume":"47","author":[{"given":"Jean-Charles","family":"Duclos-Vall\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"F\u00e9ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myl\u00e8ne","family":"Sebagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Teicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Roque-Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Bismuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Castaing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vittecoq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20241201","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/hep.510300409","article-title":", for the MULTIVIRC Group. Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients.","volume":"30","author":"Benhamou","year":"1999","journal-title":"HEPATOLOGY"},{"key":"R2-9-20241201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-8278(97)80001-3","article-title":"Human immunodeficiency virus infection modifies the natural history of chronic parenterallyacquired hepatitis C with an unusually rapid progression to cirrhosis.","volume":"26","author":"Soto","year":"1997","journal-title":"J Hepatol"},{"key":"R3-9-20241201","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1053\/jhep.2001.29201","article-title":"The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: a longterm retrospective cohort study.","volume":"34","author":"Di Martino","year":"2001","journal-title":"HEPATOLOGY"},{"key":"R4-9-20241201","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/hep.20626","article-title":"HIV coinfection shortens the survival of patients with hepatitis C virusrelated decompensated cirrhosis.","volume":"41","author":"Pineda","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R5-9-20241201","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1097\/00007890-200111270-00020","article-title":"Liver transplantation in adults coinfected with HIV.","volume":"72","author":"Prachalias","year":"2001","journal-title":"Transplantation"},{"key":"R6-9-20241201","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/jlts.2003.50054","article-title":"Orthotopic liver transplantation in patients with human immunodeficiency virus and endstage liver disease.","volume":"9","author":"Neff","year":"2003","journal-title":"Liver Transpl"},{"key":"R7-9-20241201","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1086\/379254","article-title":"Survival of human immunodeficiency virusinfected liver transplanted recipients.","volume":"188","author":"Ragni","year":"2003","journal-title":"J Infect Dis"},{"key":"R8-9-20241201","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0168-8278(03)00213-7","article-title":"Liver transplantation in patients with HIV infection.","volume":"39","author":"Samuel","year":"2003","journal-title":"J Hepatol"},{"key":"R9-9-20241201","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jhep.2004.11.029","article-title":"Hepatitis C virus viral recurrence and liver mitochondrial damage after liver transplantation in HIVHCV coinfected patients.","volume":"42","author":"DuclosVallee","year":"2005","journal-title":"J Hepatol"},{"key":"R10-9-20241201","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/lt.20233","article-title":"Outcomes of liver transplantation in HIVinfected individuals: the impact of HCV and HBV infection.","volume":"10","author":"Norris","year":"2004","journal-title":"Liver Transpl"},{"key":"R11-9-20241201","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1478-3231.2005.01031.x","article-title":"Outcome after orthotopic liver transplantation in five HIVinfected patients with virus hepatitisinduced cirrhosis.","volume":"25","author":"Radeke","year":"2005","journal-title":"Liver Int"},{"key":"R12-9-20241201","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/lt.20498","article-title":"Orthotopic liver transplantation in human immunodeficiency virus (HIV)positive patients: outcome of the 7 patients from the Bonn cohort.","volume":"11","author":"Vogel","year":"2005","journal-title":"Liver Transpl"},{"key":"R13-9-20241201","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/lt.20318","article-title":"Liver transplantation in HIVinfected recipients.","volume":"11","author":"Moreno","year":"2005","journal-title":"Liver Transpl"},{"key":"R14-9-20241201","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.tp.0000251378.70853.90","article-title":"Liver transplantation in HIVHCV coinfected patients: a casecontrol study.","volume":"83","author":"Castells","year":"2007","journal-title":"Transplantation"},{"key":"R15-9-20241201","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1111\/j.1600-6143.2006.01546.x","article-title":"Survival of liver transplant patients coinfected with HIV and HCV is adversely impacted by recurrent hepatitis C.","volume":"6","author":"de Vera","year":"2006","journal-title":"Am J Transpl"},{"key":"R16-9-20241201","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S1072-7515(99)00208-2","article-title":"Domino liver transplants for metabolic disorders: experience with familial amyloidotic polyneuropathy.","volume":"189","author":"Azoulay","year":"1999","journal-title":"J Am Coll Surg"},{"key":"R17-9-20241201","doi-asserted-by":"crossref","first-page":"F83","DOI":"10.1097\/00002030-200006160-00001","article-title":", and the CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS. A randomized study of antiretroviral management based on plasma genotype antiretroviral resistance testing in patients failing therapy.","volume":"14","author":"Baxter","year":"2000","journal-title":"AIDS"},{"key":"R18-9-20241201","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for grading activity in chronic hepatitis C.","volume":"24","author":"Bedossa","year":"1996","journal-title":"HEPATOLOGY"},{"key":"R19-9-20241201","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510250328","article-title":"Banff schema for grading liver allograft rejection: an international consensus document.","volume":"25","year":"1997","journal-title":"HEPATOLOGY"},{"key":"R20-9-20241201","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/lt.20539","article-title":"Rapid deterioration of HIV coinfected patients waiting for liver transplantation is not predicted by MELD.","volume":"11","author":"Stock","year":"2005","journal-title":"Liver Transpl"},{"key":"R21-9-20241201","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/lt.20534","article-title":"Pretransplant survival is shorter in HIVpositive than HIVnegative subjects with endstage liver disease.","volume":"11","author":"Ragni","year":"2005","journal-title":"Liver Transpl"},{"key":"R22-9-20241201","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/lt.20790","article-title":"The difficult timing for liver transplantation in cirrhotic patients coinfected with HIV. In search for a prognosis score.","volume":"12","author":"Samuel","year":"2006","journal-title":"Liver Transpl"},{"key":"R23-9-20241201","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/lt.20109","article-title":"Mitochondrial toxicity associated with HAART following liver transplantation in an HIVinfected recipient.","volume":"10","author":"Antoniades","year":"2004","journal-title":"Liver Transpl"},{"key":"R24-9-20241201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002030-200401020-00001","article-title":"Care of patients with hepatitis C and HIV coinfection.","volume":"18","author":"Soriano","year":"2004","journal-title":"AIDS"},{"issue":"suppl 2","key":"R25-9-20241201","doi-asserted-by":"crossref","first-page":"M109","DOI":"10.1177\/135965350501002S12","article-title":"The role of hepatitis C virus (HCV) in mitochondrial DNA damage in HIVHCV coinfected individuals.","volume":"10","author":"De Mendoza","year":"2005","journal-title":"Antivir Ther"},{"key":"R26-9-20241201","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/gut.51.2.248","article-title":"Advancing donor liver age and rapid fibrosis progression following transplantation for hepatitis C.","volume":"51","author":"Wali","year":"2002","journal-title":"Gut"},{"key":"R27-9-20241201","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jhep.2004.05.013","article-title":"Donor age influences 10year liver graft histology of hepatitis C virus infection.","volume":"41","author":"Rifai","year":"2004","journal-title":"J Hepatol"},{"key":"R28-9-20241201","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/jhep.2002.33993","article-title":"Contribution of donor age to the recent decrease in patient survival among HCVinfected liver transplant recipients.","volume":"36","author":"Berenguer","year":"2002","journal-title":"HEPATOLOGY"},{"key":"R29-9-20241201","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.tp.0000188619.30677.84","article-title":"Impact of donor age and year of transplantation on graft and patient survival following liver transplantation for hepatitis C virus.","volume":"15","author":"Mutimer","year":"2006","journal-title":"Transplantation"},{"key":"R30-9-20241201","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/hep.20357","article-title":"Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantation.","volume":"40","author":"GarciaRetortillo","year":"2004","journal-title":"HEPATOLOGY"},{"key":"R31-9-20241201","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.20947","article-title":"Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors.","volume":"42","author":"Schiano","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R32-9-20241201","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/jhep.2003.50449","article-title":"Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes.","volume":"38","author":"Watashi","year":"2003","journal-title":"HEPATOLOGY"},{"key":"R33-9-20241201","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.molcel.2005.05.014","article-title":"Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.","volume":"19","author":"Watashi","year":"2005","journal-title":"Mol Cell"},{"key":"R34-9-20241201","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.20087","article-title":"Frequent compartmentalization of hepatitis C virus variants in circulating B cells and monocytes.","volume":"39","author":"Ducoulombier","year":"2004","journal-title":"HEPATOLOGY"},{"key":"R35-9-20241201","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1128\/JVI.79.10.6349-6357.2005","article-title":"Compartmentalization of hepatitis C virus genotypes between plasma and peripheral blood mononuclear cells.","volume":"79","author":"RoqueAfonso","year":"2005","journal-title":"J Virol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.21990","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01515467-200802000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:56:45Z","timestamp":1786035405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01515467-200802000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.21990","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}