{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:10:48Z","timestamp":1791205848435,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2556,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>\n                                 <jats:bold>A perfect or nearly perfect human leukocyte antigen (HLA) match has been associated with better immediate and long-term survival of diseased donor kidney transplants. However, the effect of HLA matching for hepatic allografts remains poorly defined. Using data from the National Institutes of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database, we investigated the association between HLA mismatches and hepatic allograft survival, disease recurrence, and immunosuppression interactions. A, B, and DR loci were used to calculate total mismatch scores of 0 (no mismatches in any loci) to 6 (mismatches in all loci). Seven hundred ninety-nine adults (male, 55%; female, 45%) underwent 883 liver transplants. The 10-year graft survival according to total mismatch score was as follows: 0-2, 60%; 3-4, 54%; and 5-6, 57%. There was a negative effect of mismatching at the A locus on patient survival, with shorter survival for patients with 1 or 2 mismatches compared with 0 mismatches [<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.05, hazard ratio (HR) = 1.6]. Patients on tacrolimus with 1 or 2 mismatches at B or DR loci appeared to have increased rates of patient and graft survival compared to patients with 0 mismatches, with the appearance of a protective effect of tacrolimus (HR = 0.67). The effect of HLA mismatching was more pronounced on certain disease recurrences. DR-locus mismatch increased recurrence of autoimmune hepatitis (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.01, HR = 4.2) and primary biliary cirrhosis (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.04, HR = 2). Mismatch in the A locus was associated with more recurrence of hepatitis C virus (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.01, HR = 1.6) and primary sclerosing cholangitis (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.03, HR = 2.9).<\/jats:bold>\n                                 <jats:bold>\n                                    Conclusion:\n                                 <\/jats:bold>\n                                 <jats:bold>Mismatching at the A locus decreases patient survival in liver transplant recipients, and mismatching at the DR and A loci affects recurrence of autoimmune liver diseases and hepatitis C, respectively. (Hepatology 2008.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.22435","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T18:16:23Z","timestamp":1212171383000},"page":"878-888","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":96,"title":["Long-term outcome of human leukocyte antigen mismatching in liver transplantation: Results of the national institute of diabetes and digestive and kidney diseases liver transplantation database"],"prefix":"10.1097","volume":"48","author":[{"given":"Vijayan","family":"Balan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Ruppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake A.","family":"Demetris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Ledneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene J.","family":"Duquesnoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Detre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling L.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rakela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Schafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Everhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H.","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20241202","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007890-200301150-00024","article-title":"Impact of human leukocyte antigen matching in liver transplantation.","volume":"75","author":"Neumann","year":"2003","journal-title":"Transplantation"},{"key":"R2-21-20241202","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1053\/jlts.2001.26924","article-title":"Is HLA matching beneficial in liver transplantation? comment.","volume":"7","author":"Moore","year":"2001","journal-title":"Liver Transpl"},{"key":"R3-21-20241202","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/01.TP.0000101738.27552.9D","article-title":"Longterm outcome of liver transplants for chronic hepatitis C: a 10year followup.","volume":"77","author":"Neumann","year":"2004","journal-title":"Transplantation"},{"key":"R4-21-20241202","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1034\/j.1399-0012.2002.1o008.x","article-title":"Impact of HLAcompatibilities in patients undergoing liver transplantation for HBVcirrhosis.","volume":"16","author":"Neumann","year":"2002","journal-title":"Clin Transplant"},{"key":"R5-21-20241202","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/S0041-1345(00)02514-8","article-title":"A retrospective analysis of HLA matching and other factors on liver graft outcome.","volume":"33","author":"Poli","year":"2001","journal-title":"Transplant Proc"},{"key":"R6-21-20241202","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1053\/jlts.2001.27089","article-title":"Risk factors for acute rejection in pediatric living related liver transplantation: the impact of HLA matching. see comment.","volume":"7","author":"Sugawara","year":"2001","journal-title":"Liver Transpl"},{"key":"R7-21-20241202","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/lt.500040103","article-title":"The influence of hepatitis C virus genotypes on the outcome of liver transplantation. see comment.","volume":"4","author":"Vargas","year":"1998","journal-title":"Liver Transpl Surg"},{"key":"R8-21-20241202","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00007890-199807150-00009","article-title":"Role of HLA compatibility in pediatric liver transplantation.","volume":"66","author":"Francavilla","year":"1998","journal-title":"Transplantation"},{"key":"R10-21-20241202","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1399-0012.2004.00117.x","article-title":"Longterm outcome of liver transplantation for autoimmune hepatitis.","volume":"18","author":"Vogel","year":"2004","journal-title":"Clin Transplant"},{"key":"R11-21-20241202","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00423-003-0394-2","article-title":"Indications and results of liver transplantation for Echinococcus alveolar infection: an overview.","volume":"388","author":"BressonHadni","year":"2003","journal-title":"Langenbecks Arch Surg"},{"key":"R12-21-20241202","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s004230050097","article-title":"Role of HLA antigens in liver transplantation with special reference to cellular immune reactions.","volume":"383","author":"Markus","year":"1998","journal-title":"Langenbecks Arch Surg"},{"key":"R13-21-20241202","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00000478-199502000-00008","article-title":"Structural integrity and identification of causes of liver allograft dysfunction occurring more than 5 years after transplantation.","volume":"19","author":"Pappo","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"R14-21-20241202","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1056\/NEJM199410273311702","article-title":"S. 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A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation.","volume":"331","author":"The","year":"1994","journal-title":"N Engl J Med"},{"key":"R15-21-20241202","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/lt.20211","article-title":"Longterm results and modeling to predict outcomes in recipients with HCV infection: results of the NIDDK liver transplantation database.","volume":"10","author":"Charlton","year":"2004","journal-title":"Liver Transpl"},{"key":"R16-21-20241202","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/00000478-200405000-00015","article-title":"Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesis.","volume":"28","author":"Demetris","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"R17-21-20241202","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.510310337","article-title":"Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. 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Improved patient survival by HLA and crossmatching.","volume":"58","author":"Nikaein","year":"1994","journal-title":"Transplantation"},{"key":"R34-21-20241202","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00000658-198808000-00011","article-title":"Relationship between the diagnosis, preoperative evaluation, and prognosis after orthotopic liver transplantation.","volume":"208","author":"Adler","year":"1988","journal-title":"Ann Surg"},{"key":"R35-21-20241202","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/S0041-1345(00)01591-8","article-title":"Impact of HLA matching in livingrelated liver transplantation.","volume":"32","author":"Hirata","year":"2000","journal-title":"Transplant Proc"},{"key":"R36-21-20241202","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.510280306","article-title":"Acute hepatic allograft rejection: incidence, risk factors, and impact on outcome.","volume":"28","author":"Wiesner","year":"1998","journal-title":"HEPATOLOGY"},{"key":"R37-21-20241202","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/lt.500050608","article-title":"The prediction of acute cellular rejection in orthotopic liver transplantation.","volume":"5","author":"Bathgate","year":"1999","journal-title":"Liver Transpl Surg"},{"key":"R38-21-20241202","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1056\/NEJMoa011826","article-title":"Majorhistocompatibilitycomplex class I alleles and antigens in hematopoieticcell transplantation.","volume":"345","author":"Petersdorf","year":"2001","journal-title":"N Engl J Med"},{"key":"R40-21-20241202","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1056\/NEJM199603283341302","article-title":"Longterm outcome of hepatitis C infection after liver transplantation. see comment.","volume":"334","author":"Gane","year":"1996","journal-title":"N Engl J Med"},{"key":"R41-21-20241202","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/lt.20648","article-title":"Influence of donorrecipient HLAmatching on outcome and recurrence of hepatitis C after liver transplantation.","volume":"12","author":"Langrehr","year":"2006","journal-title":"Liver Transpl"},{"key":"R42-21-20241202","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1053\/jlts.2000.9741","article-title":"Liver transplantation for hepatitis C: recurrence and disease progression in 300 patients.","volume":"6","author":"Testa","year":"2000","journal-title":"Liver Transpl"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.22435","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200809000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T17:05:25Z","timestamp":1733159125000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200809000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.22435","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}