{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:35:04Z","timestamp":1789378504266,"version":"build-2803163510"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2526,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1002\/hep.22437","type":"journal-article","created":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T22:46:24Z","timestamp":1213051584000},"page":"1251-1261","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":139,"title":["The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis\u2020"],"prefix":"10.1097","volume":"48","author":[{"given":"Maria J.","family":"Perugorria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ujue","family":"Latasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nicou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Cartagena\u2010Lirola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saioa","family":"Go\u00f1i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Vespasiani\u2010Gentilucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Zagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lotersztajn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Berasain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias A.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-27-20241201","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/path.1397","article-title":"Liver extracellular matrix in health and disease","volume":"200","author":"Bedossa","year":"2003","journal-title":"J Pathol"},{"key":"R2-27-20241201","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"R3-27-20241201","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"R4-27-20241201","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev.pharmtox.45.120403.095906","article-title":"Hepatic fibrosis: molecular mechanisms and drug targets","volume":"45","author":"Lotersztajn","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R5-27-20241201","first-page":"135","article-title":"Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved","volume":"38","author":"Guyot","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"R6-27-20241201","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s004180050421","article-title":"Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo\u2010) fibroblasts subpopulations in hepatic tissue repair","volume":"112","author":"Knittel","year":"1999","journal-title":"Histochem Cell Biol"},{"key":"R7-27-20241201","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblasts subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J Hepatol"},{"key":"R8-27-20241201","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF\u2010\u03b2 as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J Cell Mol Med"},{"key":"R9-27-20241201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399403005684","article-title":"Molecular basis of hepatic fibrosis","volume":"5","author":"Hui","year":"2003","journal-title":"Expert Rev Mol Med"},{"key":"R10-27-20241201","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1172\/JCI114363","article-title":"Effects of platelet\u2010derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat\u2010storing cells","volume":"84","author":"Pinzani","year":"1989","journal-title":"J Clin Invest"},{"key":"R11-27-20241201","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1053\/j.gastro.2005.01.007","article-title":"Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor","volume":"128","author":"Svegliati\u2010Baroni","year":"2005","journal-title":"Gastroenterology"},{"key":"R12-27-20241201","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI115561","article-title":"Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells","volume":"89","author":"Bachem","year":"1992","journal-title":"J Clin Invest"},{"key":"R13-27-20241201","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0006-291X(89)92368-1","article-title":"Liver fat storing cell proliferation is stimulated by epidermal growth factor\/transforming growth factor alpha and inhibited by transforming growth factor beta","volume":"162","author":"Bachem","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"R14-27-20241201","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","article-title":"Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors","volume":"124","author":"Yang","year":"2003","journal-title":"Gastroenterology"},{"key":"R15-27-20241201","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1478-3231.2006.01424.x","article-title":"New molecular targets for hepatocellular carcinoma: the Erbb1 signaling system","volume":"27","author":"Berasain","year":"2007","journal-title":"Liver Int"},{"key":"R16-27-20241201","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1053\/j.gastro.2004.11.006","article-title":"Amphiregulin: an early trigger for liver regeneration in mice","volume":"128","author":"Berasain","year":"2005","journal-title":"Gastroenterology"},{"key":"R17-27-20241201","doi-asserted-by":"crossref","first-page":"19012","DOI":"10.1074\/jbc.M413344200","article-title":"Novel role for amphiregulin in protection from liver injury","volume":"280","author":"Berasain","year":"2005","journal-title":"J Biol Chem"},{"key":"R18-27-20241201","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrm1548","article-title":"ADAMs: key components in EGFR signalling and development","volume":"6","author":"Blobel","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R19-27-20241201","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/taap.1998.8547","article-title":"Resistance to carbon tetrachloride\u2010induced hepatotoxicity in mice which lack CYP2E1 expression","volume":"153","author":"Wong","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"key":"R20-27-20241201","first-page":"1538","article-title":"Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4\u2010induced fibrotic rat livers","volume":"23","author":"Niki","year":"1996","journal-title":"HEPATOLOGY"},{"key":"R21-27-20241201","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis\u2010a systematic review with special emphasis on anti\u2010fibrotic strategies","volume":"46","author":"Hemann","year":"2007","journal-title":"J Hepatol"},{"key":"R22-27-20241201","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep.21419","article-title":"STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity","volume":"44","author":"Jeong","year":"2006","journal-title":"HEPATOLOGY"},{"key":"R23-27-20241201","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10495-005-1055-4","article-title":"The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis","volume":"10","author":"Elsharkawy","year":"2005","journal-title":"Apoptosis"},{"key":"R24-27-20241201","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gut.2005.082701","article-title":"Overexpression of Bcl\u20102 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans","volume":"55","author":"Novo","year":"2006","journal-title":"Gut"},{"key":"R25-27-20241201","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.biocel.2005.11.001","article-title":"The grape\u2010derived polyphenol resveratrol differentially affects epidermal and platelet\u2010derived growth factor signaling in human liver myofibroblasts","volume":"38","author":"Godichaud","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"R26-27-20241201","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/labinvest.3700532","article-title":"The interruption of the PDGF and EGF signalling pathways by curcumin stimulates gene expression of PPAR\u03b3 in rat activated hepatic stellate cell in vitro","volume":"87","author":"Zhou","year":"2007","journal-title":"Lab Invest"},{"key":"R27-27-20241201","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1172\/JCI118304","article-title":"Activation of hepatic stellate cells by TGF\u03b1 and collagen type I is mediated by oxidative stress through c\u2010myb expression","volume":"96","author":"Lee","year":"1995","journal-title":"J Clin Invest"},{"key":"R28-27-20241201","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1074\/jbc.M212927200","article-title":"The role of focal adhesion kinase\u2010phosphatidylinositol 3\u2010kinase\u2010Akt signaling in hepatic stellate cell proliferation and type I collagen expression","volume":"278","author":"Reif","year":"2003","journal-title":"J Biol Chem"},{"key":"R29-27-20241201","first-page":"28","article-title":"Cytokines and cellular crosstalk involved in the activation of fat\u2010storing cells","volume":"22","author":"Gressner","year":"1995","journal-title":"J Hepatol"},{"key":"R30-27-20241201","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF\u2010\u03b2 signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"R31-27-20241201","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.4049\/jimmunol.178.8.5288","article-title":"Scar\u2010associated macrophages are a major source of hepatic matrix metalloproteinase\u201013 and facilitate the resolution of murine hepatic fibrosis","volume":"178","author":"Fallowfield","year":"2007","journal-title":"J Immunol"},{"key":"R32-27-20241201","doi-asserted-by":"crossref","first-page":"11069","DOI":"10.1074\/jbc.M111490200","article-title":"Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase\u20101 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis","volume":"277","author":"Murphy","year":"2002","journal-title":"J Biol Chem"},{"key":"R33-27-20241201","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1074\/jbc.M308351200","article-title":"Leptin stimulates tissue inhibitor of metalloproteinase\u20101 in human hepatic stellate cells","volume":"279","author":"Cao","year":"2004","journal-title":"J Biol Chem"},{"key":"R34-27-20241201","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/hep.21427","article-title":"Oxidative\u2010stress and IL\u20106 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells","volume":"44","author":"Nieto","year":"2006","journal-title":"HEPATOLOGY"},{"key":"R35-27-20241201","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.gt.3302929","article-title":"siRNA\u2010mediated knockdown of connective tissue growth factor prevents N\u2010nitrosodimethylamine\u2010induced hepatic fibrosis in rats","volume":"14","author":"George","year":"2007","journal-title":"Gene Ther"},{"key":"R36-27-20241201","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.LAB.0000017365.18894.D3","article-title":"Effects and regulation of connective tissue growth factor on hepatic stellate cells","volume":"82","author":"Paradis","year":"2002","journal-title":"Lab Invest"},{"key":"R37-27-20241201","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0168-8278(05)80008-X","article-title":"The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast\u2010like cells in culture","volume":"18","author":"Bachem","year":"1993","journal-title":"J Hepatol"},{"key":"R38-27-20241201","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/hep.510300406","article-title":"Extracellular signal\u2010regulated kinase activation differentially regulates platelet\u2010derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat","volume":"30","author":"Marra","year":"1999","journal-title":"HEPATOLOGY"},{"key":"R39-27-20241201","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1096\/fj.04-1847fje","article-title":"Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation","volume":"18","author":"Saxena","year":"2004","journal-title":"FASEB J"},{"key":"R40-27-20241201","doi-asserted-by":"crossref","first-page":"37323","DOI":"10.1074\/jbc.M202798200","article-title":"Sphingosine 1\u2010phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts","volume":"277","author":"Davaille","year":"2002","journal-title":"J Biol Chem"},{"key":"R41-27-20241201","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1165\/ajrcmb.20.5.3526","article-title":"Transforming growth factor\u2010\u03b1 deficiency reduces pulmonary fibrosis in transgenic mice","volume":"20","author":"Madtes","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R42-27-20241201","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm1275","article-title":"Angiotensin II and EGF receptor cross\u2010talk in chronic kidney diseases: a new therapeutic approach","volume":"11","author":"Lautrette","year":"2005","journal-title":"Nat Med"},{"key":"R43-27-20241201","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1096\/fj.03-0702fje","article-title":"Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition","volume":"18","author":"Fran\u00e7ois","year":"2004","journal-title":"FASEB J"},{"key":"R44-27-20241201","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.20538","article-title":"Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis","volume":"41","author":"Schiffer","year":"2005","journal-title":"HEPATOLOGY"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.22437","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200810000-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T12:18:53Z","timestamp":1733055533000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200810000-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.22437","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}