{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:32:49Z","timestamp":1790836369286,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2526,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1002\/hep.22445","type":"journal-article","created":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T20:46:45Z","timestamp":1213044405000},"page":"1184-1192","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":51,"title":["Control of acute, chronic, and constitutive hyperammonemia by wild\u2010type and genetically engineered Lactobacillus plantarum in rodents\u2020"],"prefix":"10.1097","volume":"48","author":[{"given":"Charles","family":"Nicaise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Prozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Viaene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Gustot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Quertinmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Demetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Suain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Goffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Devi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Hols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20241201","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1111\/j.1572-0241.2001.03964.x","article-title":"Hepatic encephalopathy","volume":"96","author":"Blei","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"R2-20-20241201","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/jhep.2002.31250","article-title":"Hepatic encephalopathy\u2010definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998","volume":"35","author":"Ferenci","year":"2002","journal-title":"HEPATOLOGY"},{"key":"R3-20-20241201","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00005792-200205000-00007","article-title":"Hyperammonemic encephalopathy","volume":"81","author":"Brusilow","year":"2002","journal-title":"Medicine"},{"key":"R4-20-20241201","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/qjmed\/hcg110","article-title":"The neurology of liver failure","volume":"96","author":"Lewis","year":"2003","journal-title":"Q J Med"},{"key":"R5-20-20241201","first-page":"240","article-title":"Hepatic encephalopathy","volume":"27","author":"Butterworth","year":"2003","journal-title":"Alcohol Res Health"},{"key":"R6-20-20241201","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/jcbfm.1991.67","article-title":"Cerebral ammonia metabolism in patients with severe liver\u2010disease and minimal hepatic\u2010encephalopathy","volume":"11","author":"Lockwood","year":"1991","journal-title":"J Cereb Blood Flow Metab"},{"key":"R7-20-20241201","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0168-8278(01)00026-5","article-title":"Neuropsychological characterization of hepatic encephalopathy","volume":"34","author":"Weissenborn","year":"2001","journal-title":"J Hepatol"},{"key":"R8-20-20241201","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.clinbiochem.2005.04.013","article-title":"Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension","volume":"38","author":"Kundra","year":"2005","journal-title":"Clin Biochem"},{"key":"R9-20-20241201","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/gut.2004.061754","article-title":"Predictive value of arterial ammonia for complications and outcome in acute liver failure","volume":"55","author":"Bhatia","year":"2006","journal-title":"Gut"},{"key":"R10-20-20241201","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(95)01244-3","article-title":"Acute liver failure and hyperammonemia increase peripheral\u2010type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain","volume":"705","author":"Itzhak","year":"1995","journal-title":"Brain Res"},{"key":"R11-20-20241201","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/he.2000.5636","article-title":"Hepatocyte transplantation in rats with decompensated cirrhosis","volume":"31","author":"Kobayashi","year":"2000","journal-title":"HEPATOLOGY"},{"key":"R12-20-20241201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(00)02589-0","article-title":"Impaired cognitive performance in ornithine transcarbamylase\u2010deficient mice on arginine\u2010free diet","volume":"876","author":"D'hooge","year":"2000","journal-title":"Brain Res"},{"key":"R13-20-20241201","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.hepres.2004.08.013","article-title":"Ammonia metabolism and hepatic encephalopathy","volume":"30","author":"Katayama","year":"2004","journal-title":"Hepatol Res"},{"key":"R14-20-20241201","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpg.2003.10.008","article-title":"Microbial\u2010gut interactions in health and disease. Prebiotics","volume":"18","author":"Manning","year":"2004","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"R15-20-20241201","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0016-5085(90)90825-L","article-title":"The degradation of amino\u2010acids, proteins, and blood to short\u2010chain fatty\u2010acids in colon is prevented by lactulose","volume":"98","author":"Mortensen","year":"1990","journal-title":"Gastroenterology"},{"key":"R16-20-20241201","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJM199708143370707","article-title":"Treatment of hepatic encephalopathy","volume":"337","author":"Riordan","year":"1997","journal-title":"N Engl J Med"},{"key":"R17-20-20241201","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0140-6736(05)70239-7","article-title":"Dispelling myths in the treatment of hepatic encephalopathy","volume":"365","author":"Shawcross","year":"2005","journal-title":"Lancet"},{"key":"R18-20-20241201","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/bmj.329.7457.112","article-title":"Treatment of hepatic encephalopathy \u2010 It's not lactulose","volume":"329","author":"Shawcross","year":"2004","journal-title":"Br Med J"},{"key":"R19-20-20241201","first-page":"A745","article-title":"Comparison of the effect of long\u2010term administration of OF\u2010IN ingested in combination with Lactobacillus casei Shirota with OF\u2010IN alone on the colonic fate of protein fermentation metabolites NH3 and phenols","volume":"130","author":"De Preter","year":"2006","journal-title":"Gastroenterology"},{"key":"R20-20-20241201","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0306-9877(03)00192-0","article-title":"Probiotics can treat hepatic encephalopathy","volume":"61","author":"Solga","year":"2003","journal-title":"Med Hypotheses"},{"key":"R21-20-20241201","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep.20194","article-title":"Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis","volume":"39","author":"Liu","year":"2004","journal-title":"HEPATOLOGY"},{"key":"R22-20-20241201","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3748\/wjg.v11.i6.908","article-title":"Comparison of probiotics and lactulose in the treatment of minimal hepatic encephalopathy in rats","volume":"11","author":"Jia","year":"2005","journal-title":"World J Gastroenterol"},{"key":"R23-20-20241201","doi-asserted-by":"crossref","first-page":"430S","DOI":"10.1093\/ajcn\/73.2.430s","article-title":"Protection from gastrointestinal diseases with the use of probiotics","volume":"73","author":"Marteau","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"R24-20-20241201","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1053\/gast.2000.9370","article-title":"Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double\u2010blind, placebo\u2010controlled trial","volume":"119","author":"Gionchetti","year":"2000","journal-title":"Gastroenterology"},{"key":"R25-20-20241201","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0923-2508(01)01254-2","article-title":"Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea","volume":"152","author":"Brigidi","year":"2001","journal-title":"Res Microbiol"},{"key":"R26-20-20241201","first-page":"453","article-title":"Is Lactobacillus GG helpful in children with Crohn's disease? Results of a preliminary, open\u2010label study","volume":"31","author":"Gupta","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R27-20-20241201","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1016\/S0264-410X(03)00522-X","article-title":"Reduced experimental autoimmune encephalomyelitis after intranasal and oral administration of recombinant lactobacilli expressing myelin antigens","volume":"21","author":"Maassen","year":"2003","journal-title":"Vaccine"},{"key":"R28-20-20241201","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.289.5483.1352","article-title":"Treatment of murine colitis by Lactococcus lactis secreting interleukin\u201010","volume":"289","author":"Steidler","year":"2000","journal-title":"Science"},{"key":"R29-20-20241201","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.cgh.2006.03.028","article-title":"A phase I trial with Transgenic bacteria expressing interleukin\u201010 in Crohn's disease","volume":"4","author":"Braat","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R30-20-20241201","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0963-9969(92)90121-K","article-title":"Transformation of Lactobacillus strains used in meat and vegetable fermentations","volume":"25","author":"Aukrust","year":"1992","journal-title":"Food Res Int"},{"key":"R31-20-20241201","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1128\/JB.187.19.6750-6761.2005","article-title":"Lactate racemization as a rescue pathway for supplying D\u2010lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum","volume":"187","author":"Goffin","year":"2005","journal-title":"J Bacteriol"},{"key":"R32-20-20241201","first-page":"G455","article-title":"Azoxymethane\u2010induced fulminant hepatic failure in C57BL\/6J mice: characterization of a new animal model","volume":"277","author":"Matkowskyj","year":"1999","journal-title":"Am J Physiol"},{"key":"R33-20-20241201","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0140-6736(65)90002-4","article-title":"Treatment of hepatic encephalopathy by alteration of intestinal flora with Lactobacillus acidophilus","volume":"1","author":"Macbeth","year":"1965","journal-title":"Lancet"},{"key":"R34-20-20241201","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1136\/bmj.1.5498.1267","article-title":"Lactobacillus acidophilus (Enpac) in treatment of hepatic encephalopathy","volume":"1","author":"Read","year":"1966","journal-title":"Br Med J"},{"key":"R35-20-20241201","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0168-8278(95)80309-2","article-title":"Long\u2010term effects of Enterococcus faecium Sf68 versus lactulose in the treatment of patients with cirrhosis and grade 1\u20132 hepatic\u2010encephalopathy","volume":"23","author":"Loguercio","year":"1995","journal-title":"J Hepatol"},{"key":"R36-20-20241201","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1073\/pnas.062043799","article-title":"Ammonium\/methylammonium transport (Amt) proteins facilitate diffusion of NH3 bidirectionally","volume":"99","author":"Soupene","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R37-20-20241201","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1073\/pnas.95.12.7030","article-title":"Ammonia acquisition in enteric bacteria: Physiological role of the ammonium\/methylammonium transport B (AmtB) protein","volume":"95","author":"Soupene","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R38-20-20241201","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1529\/biophysj.106.089714","article-title":"Ammonium recruitment and ammonia transport by E. coli ammonia channel AmtB","volume":"91","author":"Nygaard","year":"2006","journal-title":"Biophys J"},{"key":"R39-20-20241201","first-page":"875","article-title":"Detailed mechanism for AmtB conducting NH4 +\/NH3: molecular dynamics simulations","volume":"92","author":"Yang","year":"2006","journal-title":"Biophys J"},{"key":"R40-20-20241201","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1128\/AEM.00109-06","article-title":"Selecting lactic acid bacteria for their safety and functionality by use of a mouse colitis model","volume":"72","author":"Daniel","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"R41-20-20241201","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S1521-6918(03)00072-6","article-title":"Genetically engineered probiotics","volume":"17","author":"Steidler","year":"2003","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"R42-20-20241201","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1073\/pnas.0504084102","article-title":"Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids","volume":"102","author":"Grangette","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R43-20-20241201","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1128\/AEM.02304-06","article-title":"High\u2010level production of the low\u2010calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering","volume":"73","author":"Ladero","year":"2007","journal-title":"Appl Environ Microbiol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.22445","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200810000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T12:19:56Z","timestamp":1733055596000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200810000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.22445","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}