{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:11:33Z","timestamp":1791169893529,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2314,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Chronic ethanol feeding decreases expression of adiponectin by adipocytes and circulating adiponectin. Adiponectin treatment during chronic ethanol feeding prevents liver injury in mice. Chronic ethanol feeding also increases oxidative and endoplasmic reticulum (ER) stress in adipose tissue. Here we tested the hypothesis that supplemental taurine, an amino acid that functions as a chemical chaperone\/osmolyte and enhances cellular antioxidant activity, would prevent ethanol-induced decreases in adiponectin expression and attenuate liver injury. Serum adiponectin concentrations decreased as early as 4 to 7 days after feeding rats a 36% ethanol diet. This rapid decrease was associated with increased oxidative, but not ER, stress in subcutaneous adipose tissue. Taurine prevented ethanol-induced oxidative stress and increased inflammatory cytokine expression in adipose tissue. Ethanol feeding also rapidly decreased expression of transcription factors regulating adiponectin expression (CCAAT\/enhancer binding protein \u03b1; peroxisome proliferator-activated receptor \u03b1\/\u03b3) in subcutaneous adipose tissue. Taurine prevented the ethanol-induced decrease in CCAAT\/enhancer binding protein \u03b1 and peroxisome proliferator-activated receptor \u03b1, normalizing adiponectin messenger (m)RNA and serum adiponectin concentrations. In the liver, taurine prevented ethanol-induced oxidative stress and attenuated tumor necrosis factor \u03b1 expression and steatosis, at least in part, by increasing expression of genes involved in fatty acid oxidation. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: In subcutaneous adipose tissue, taurine decreased ethanol-induced oxidative stress and cytokine expression, as well as normalized expression of adiponectin mRNA. Taurine prevented ethanol-induced decreases in serum adiponectin; normalized adiponectin was associated with a reduction in hepatic oxidative stress, tumor necrosis factor \u03b1 expression, and steatosis. Taken together, these data demonstrate that taurine has important protective effects against ethanol-induced tissue injury in both adipose and liver tissue. (Hepatology 2009.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.22811","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T23:30:27Z","timestamp":1230766227000},"page":"1554-1562","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":103,"title":["Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats #"],"prefix":"10.1097","volume":"49","author":[{"given":"Xiaocong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky M.","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armend","family":"Axhemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20241201","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors.","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr Rev"},{"key":"R2-18-20241201","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel, adiposespecific protein, adiponectin, in type 2 diabetic patients.","volume":"20","author":"Hotta","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R3-18-20241201","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.1074\/jbc.271.18.10697","article-title":"AdipoQ is a novel adiposespecific gene dysregulated in obesity.","volume":"271","author":"Hu","year":"1996","journal-title":"J Biol Chem"},{"key":"R4-18-20241201","first-page":"R1220","article-title":"Adiponectin inhibits LPSinduced NFkappaB activation and IL6 production and increases PPARgamma2 expression in adipocytes.","volume":"288","author":"Ajuwon","year":"2005","journal-title":"Am J Physiol"},{"key":"R6-18-20241201","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI200317797","article-title":"The fatderived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"R7-18-20241201","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/hep.20821","article-title":"Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice.","volume":"42","author":"You","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R8-18-20241201","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/hep.22074","article-title":"Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.","volume":"47","author":"Song","year":"2008","journal-title":"HEPATOLOGY"},{"key":"R9-18-20241201","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1152\/ajpgi.00553.2005","article-title":"Adiponectin normalizes LPSstimulated TNFalpha production by rat Kupffer cells after chronic ethanol feeding.","volume":"290","author":"Thakur","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R10-18-20241201","doi-asserted-by":"crossref","first-page":"E621","DOI":"10.1152\/ajpendo.00387.2006","article-title":"Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes.","volume":"292","author":"Chen","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"Pt 2","key":"R11-18-20241201","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1042\/bj3540323","article-title":"GLUT4 vesicle trafficking in rat adipocytes after ethanol feeding: regulation by heterotrimeric Gproteins.","volume":"354","author":"Poirier","year":"2001","journal-title":"Biochem J"},{"key":"R12-18-20241201","doi-asserted-by":"crossref","first-page":"28465","DOI":"10.1074\/jbc.M705503200","article-title":"Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the antilipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation.","volume":"282","author":"Kang","year":"2007","journal-title":"J Biol Chem"},{"key":"R13-18-20241201","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1530-0277.2007.00452.x","article-title":"Chronic ethanolinduced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines.","volume":"31","author":"Kang","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"R14-18-20241201","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue.","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"R15-18-20241201","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ.","volume":"89","author":"Kershaw","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-18-20241201","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"R17-18-20241201","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1379\/1466-1268(1996)001<0109:IOMACC>2.3.CO;2","article-title":"Influence of molecular and chemical chaperones on protein folding.","volume":"1","author":"Welch","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"R18-18-20241201","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"R19-18-20241201","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/dmrr.229","article-title":"The role of taurine in diabetes and the development of diabetic complications.","volume":"17","author":"Hansen","year":"2001","journal-title":"Diabetes Metab Res Rev"},{"key":"R20-18-20241201","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.mco.0000247469.26414.55","article-title":"Is taurine a functional nutrient?","volume":"9","author":"Bouckenooghe","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"R21-18-20241201","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1053\/j.gastro.2007.01.053","article-title":"Differential contributions of C3, C5, and decayaccelerating factor to ethanolinduced fatty liver in mice.","volume":"132","author":"Pritchard","year":"2007","journal-title":"Gastroenterology"},{"key":"R22-18-20241201","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ab.2006.10.010","article-title":"An HPLCbased fluorometric assay for cobalaminindependent methionine synthase.","volume":"360","author":"Cross","year":"2007","journal-title":"Anal Biochem"},{"key":"R23-18-20241201","doi-asserted-by":"crossref","first-page":"18073","DOI":"10.1074\/jbc.M414231200","article-title":"Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes.","volume":"280","author":"Xu","year":"2005","journal-title":"J Biol Chem"},{"key":"R24-18-20241201","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0016-5085(03)00276-2","article-title":"Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcoholfed mice.","volume":"124","author":"Ji","year":"2003","journal-title":"Gastroenterology"},{"key":"R25-18-20241201","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.nutr.24.012003.132258","article-title":"Molecular aspects of alcohol metabolism: transcription factors involved in early ethanolinduced liver injury.","volume":"24","author":"Nagy","year":"2004","journal-title":"Annu Rev Nutr"},{"key":"R26-18-20241201","doi-asserted-by":"crossref","first-page":"22108","DOI":"10.1074\/jbc.M400238200","article-title":"Adipocyte determination and differentiationdependent factor 1sterol regulatory elementbinding protein 1c regulates mouse adiponectin expression.","volume":"279","author":"Seo","year":"2004","journal-title":"J Biol Chem"},{"key":"R27-18-20241201","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/diabetes.52.7.1655","article-title":"Induction of adiponectin, a fatderived antidiabetic and antiatherogenic factor, by nuclear receptors.","volume":"52","author":"Iwaki","year":"2003","journal-title":"Diabetes"},{"key":"R28-18-20241201","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2337\/diabetes.53.11.2757","article-title":"CCAATenhancer binding protein and nuclear factorY regulate adiponectin gene expression in adipose tissue.","volume":"53","author":"Park","year":"2004","journal-title":"Diabetes"},{"key":"R29-18-20241201","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bbrc.2005.08.203","article-title":"Effect of PPARalpha and gamma agonist on the expression of visfatin, adiponectin, and TNFalpha in visceral fat of OLETF rats.","volume":"336","author":"Choi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R30-18-20241201","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2337\/diacare.29.02.06.dc05-1418","article-title":"Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients.","volume":"29","author":"Koh","year":"2006","journal-title":"Diabetes Care"},{"key":"R31-18-20241201","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.alcohol.2004.07.004","article-title":"Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory elementbinding proteins.","volume":"34","author":"You","year":"2004","journal-title":"Alcohol"},{"key":"R32-18-20241201","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.alcohol.2004.07.005","article-title":"Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferatoractivated receptor alpha.","volume":"34","author":"Crabb","year":"2004","journal-title":"Alcohol"},{"key":"R33-18-20241201","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1124\/jpet.104.067066","article-title":"Expression and induction of cytochromes p450 in rat white adipose tissue.","volume":"311","author":"Yoshinari","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"R34-18-20241201","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.","volume":"9","author":"Guilherme","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R36-18-20241201","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1053\/j.gastro.2005.02.065","article-title":"Early growth response1 transcription factor is essential for ethanolinduced fatty liver injury in mice.","volume":"128","author":"McMullen","year":"2005","journal-title":"Gastroenterology"},{"key":"R37-18-20241201","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13813450500500399","article-title":"GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in CEBP alpha and delta isoforms in 3T3-L1 adipocytes.","volume":"112","author":"PesslerCohen","year":"2006","journal-title":"Arch Physiol Biochem"},{"key":"R38-18-20241201","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00056.2004","article-title":"Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.","volume":"287","author":"You","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R39-18-20241201","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/alcalc\/34.4.529","article-title":"Reversal of ethanolinduced hepatic steatosis and lipid peroxidation by taurine: a study in rats.","volume":"34","author":"Kerai","year":"1999","journal-title":"Alcohol Alcohol"},{"key":"R40-18-20241201","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00726-002-0212-0","article-title":"Treatment of hypertension with oral taurine: experimental and clinical studies.","volume":"23","author":"Militante","year":"2002","journal-title":"Amino Acids"},{"key":"R41-18-20241201","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00726-006-0291-4","article-title":"The effect of taurine depletion on the contractile properties and fatigue in fasttwitch skeletal muscle of the mouse.","volume":"31","author":"Hamilton","year":"2006","journal-title":"Amino Acids"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.22811","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200905000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T13:45:38Z","timestamp":1733060738000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200905000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.22811","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}