{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:08:13Z","timestamp":1789650493493,"version":"4.0.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1708,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1002\/hep.24044","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T12:17:22Z","timestamp":1287404242000},"page":"527-535","source":"Crossref","is-referenced-by-count":64,"title":["B cell depletion therapy exacerbates murine primary biliary cirrhosis"],"prefix":"10.1097","volume":"53","author":[{"given":"Amy","family":"Dhirapong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Kehry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Packard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Cambier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"Coppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2010,12,28]]},"reference":[{"key":"10.1002\/hep.24044-BIB1|cit1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3109\/08916930903374600","article-title":"Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future","volume":"43","author":"Jacob","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1002\/hep.24044-BIB2|cit2","first-page":"3420","article-title":"Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression","volume":"118","author":"Matsushita","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.24044-BIB3|cit3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jaut.2009.02.021","article-title":"B cells contribute to ischemia\/reperfusion-mediated tissue injury","volume":"32","author":"Chen","year":"2009","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB4|cit4","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1172\/JCI28330","article-title":"Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell\/B cell cooperation","volume":"116","author":"Krishnamoorthy","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.24044-BIB5|cit5","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1182\/blood-2009-04-211417","article-title":"Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells","volume":"114","author":"Allan","year":"2009","journal-title":"Blood"},{"key":"10.1002\/hep.24044-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/intimm\/13.12.1583","article-title":"Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations","volume":"13","author":"Rivera","year":"2001","journal-title":"Int Immunol"},{"key":"10.1002\/hep.24044-BIB7|cit7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jaut.2009.02.009","article-title":"Selective regulation of autoreactive B cells by FcgammaRIIB","volume":"32","author":"Venkatesh","year":"2009","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB8|cit8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.192.4.475","article-title":"B lymphocytes regulate dendritic cell (DC) function in vivo: increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation","volume":"192","author":"Moulin","year":"2000","journal-title":"J Exp Med"},{"key":"10.1002\/hep.24044-BIB9|cit9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ni0901-764","article-title":"Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity","volume":"2","author":"Lipsky","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1002\/hep.24044-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.4049\/jimmunol.164.4.1658","article-title":"Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation","volume":"164","author":"Chan","year":"2000","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB11|cit11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2249.2009.03977.x","article-title":"Translational mini-review series on B cell-directed therapies: B cell-directed therapy for autoimmune diseases","volume":"157","author":"Hu","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.24044-BIB12|cit12","first-page":"3260","article-title":"Paradox of B cell-targeted therapies","volume":"118","author":"Kurosaki","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.24044-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1056\/NEJMoa0904452","article-title":"Rituximab, B-lymphocyte depletion, and preservation of beta-cell function","volume":"361","author":"Pescovitz","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.24044-BIB14|cit14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jaut.2009.11.002","article-title":"Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression","volume":"34","author":"Korganow","year":"2010","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB15|cit15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jaut.2008.04.006","article-title":"The development of targeted therapies in rheumatoid arthritis","volume":"31","author":"Vital","year":"2008","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB16|cit16","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.85.19.7317","article-title":"Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase","volume":"85","author":"Coppel","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.24044-BIB17|cit17","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.138.10.3525","article-title":"Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis","volume":"138","author":"Gershwin","year":"1987","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJM198905253202104","article-title":"Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis","volume":"320","author":"Van de Water","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.24044-BIB19|cit19","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/hep.1840180315","article-title":"Distribution of B lymphocytes in nonsuppurative cholangitis in primary biliary cirrhosis","volume":"18","author":"Nakanuma","year":"1993","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB20|cit20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2009.08.009","article-title":"A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis","volume":"34","author":"Agmon-Levin","year":"2010","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB21|cit21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/hep.510260103","article-title":"Does antimitochondrial antibody status affect response to treatment in patients with primary biliary cirrhosis? Outcomes of ursodeoxycholic acid therapy and liver transplantation","volume":"26","author":"Kim","year":"1997","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB22|cit22","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/hep.510250507","article-title":"Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and -negative primary biliary cirrhosis","volume":"25","author":"Invernizzi","year":"1997","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4049\/jimmunol.177.3.1655","article-title":"Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice","volume":"177","author":"Oertelt","year":"2006","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB24|cit24","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/hep.23238","article-title":"B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice","volume":"50","author":"Moritoki","year":"2009","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB25|cit25","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.4049\/jimmunol.174.9.5874","article-title":"Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid","volume":"174","author":"Amano","year":"2005","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB26|cit26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2006.06.002","article-title":"Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis","volume":"27","author":"Rieger","year":"2006","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB27|cit27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/hep.22390","article-title":"Loss of tolerance in C57BL\/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease","volume":"48","author":"Wakabayashi","year":"2008","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB28|cit28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2249.2008.03837.x","article-title":"Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization","volume":"155","author":"Wakabayashi","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.24044-BIB29|cit29","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.179.4.2651","article-title":"Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization","volume":"179","author":"Leung","year":"2007","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB30|cit30","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.4049\/jimmunol.180.7.4994","article-title":"Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity","volume":"180","author":"Hamel","year":"2008","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB31|cit31","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.181.5.2961","article-title":"B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL\/lpr mice","volume":"181","author":"Li","year":"2008","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB32|cit32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/jhep.2001.26514","article-title":"Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens","volume":"34","author":"Miyakawa","year":"2001","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB33|cit33","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1053\/j.gastro.2009.08.004","article-title":"Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production","volume":"137","author":"Lafdil","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.24044-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1053\/j.gastro.2008.11.035","article-title":"B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis","volume":"136","author":"Moritoki","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.24044-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/hep.21385","article-title":"IL-2 receptor alpha(-\/-) mice and the development of primary biliary cirrhosis","volume":"44","author":"Wakabayashi","year":"2006","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB36|cit36","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.4049\/jimmunol.180.5.2863","article-title":"B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions","volume":"180","author":"Xiu","year":"2008","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB37|cit37","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2353\/ajpath.2006.060205","article-title":"B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis","volume":"169","author":"Hasegawa","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.24044-BIB38|cit38","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.176.2.705","article-title":"A case for regulatory B cells","volume":"176","author":"Mizoguchi","year":"2006","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB39|cit39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jaut.2008.04.025","article-title":"B cells limit epitope spreading and reduce severity of EAE induced with PLP peptide in BALB\/c mice","volume":"31","author":"Lyons","year":"2008","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB40|cit40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1074-7613(02)00274-1","article-title":"Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation","volume":"16","author":"Mizoguchi","year":"2002","journal-title":"Immunity"},{"key":"10.1002\/hep.24044-BIB41|cit41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.20021293","article-title":"Prevention of arthritis by interleukin 10-producing B cells","volume":"197","author":"Mauri","year":"2003","journal-title":"J Exp Med"},{"key":"10.1002\/hep.24044-BIB42|cit42","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.4049\/jimmunol.1001307","article-title":"Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis","volume":"185","author":"Matsushita","year":"2010","journal-title":"J Immunol"},{"key":"10.1002\/hep.24044-BIB43|cit43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nri2315","article-title":"Not always the bad guys: B cells as regulators of autoimmune pathology","volume":"8","author":"Fillatreau","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1002\/hep.24044-BIB44|cit44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jaut.2009.09.012","article-title":"Alternatively activated macrophages in infection and autoimmunity","volume":"33","author":"Fairweather","year":"2009","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB45|cit45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/156652409787314525","article-title":"Innate immunity and primary biliary cirrhosis","volume":"9","author":"Selmi","year":"2009","journal-title":"Curr Mol Med"},{"key":"10.1002\/hep.24044-BIB46|cit46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jaut.2006.04.001","article-title":"Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis","volume":"26","author":"Chuang","year":"2006","journal-title":"J Autoimmun"},{"key":"10.1002\/hep.24044-BIB47|cit47","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.20859","article-title":"Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis","volume":"42","author":"Mao","year":"2005","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.24044-BIB48|cit48","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1002\/hep.24044-BIB49|cit49","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/eji.1830270526","article-title":"Effect of interleukin-10 on dendritic cell maturation and function","volume":"27","author":"De Smedt","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1002\/hep.24044-BIB50|cit50","first-page":"550","article-title":"Rituximab for primary biliary cirrhosis (PBC) refractory to ursodeoxycholic acid (UDCA)","volume":"46","author":"Myers","year":"2007","journal-title":"HEPATOLOGY"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.24044","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1002\/hep.24044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:27:10Z","timestamp":1789648030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1002\/hep.24044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,28]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.24044","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,28]]}}}