{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:26:20Z","timestamp":1738992380629,"version":"3.37.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1645,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1002\/hep.24205","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T10:05:41Z","timestamp":1296122741000},"page":"723-725","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Of Mice and Men: the Nonrandom Genomic Instability in Hepatocarcinogenesis \u0394\u03c3"],"prefix":"10.1097","volume":"53","author":[{"given":"Diego F.","family":"Calvisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-2-20250207","doi-asserted-by":"crossref","first-page":"220228","DOI":"10.1038\/nrm2858","article-title":"Genomic instabilityan evolving hallmark of cancer.","volume":"11","author":"Negrini","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R2-2-20250207","doi-asserted-by":"crossref","first-page":"761763","DOI":"10.1038\/386761a0","article-title":"Cancersusceptibility genes. Gatekeepers and caretakers.","volume":"386","author":"Kinzler","year":"1997","journal-title":"Nature"},{"key":"R3-2-20250207","first-page":"22732","article-title":"Inherited variants of MYH associated with somatic G:CT:A mutations in colorectal tumors.","volume":"30","author":"AlTassan","year":"2002","journal-title":"Nat Genet"},{"key":"R4-2-20250207","doi-asserted-by":"crossref","first-page":"970979","DOI":"10.1053\/jhep.2000.19797","article-title":"Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosisA comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma.","volume":"32","author":"Kondo","year":"2000","journal-title":"HEPATOLOGY"},{"key":"R5-2-20250207","doi-asserted-by":"crossref","first-page":"13741386","DOI":"10.1053\/j.gastro.2004.02.014","article-title":"Disruption of betacatenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.","volume":"126","author":"Calvisi","year":"2004","journal-title":"Gastroenterology"},{"key":"R6-2-20250207","first-page":"17631773","article-title":"Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis.","volume":"120","author":"LaurentPuig","year":"2001","journal-title":"Gastroenterology"},{"key":"R8-2-20250207","doi-asserted-by":"crossref","first-page":"376380","DOI":"10.3748\/wjg.v10.i3.376","article-title":"Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma.","volume":"10","author":"Xiao","year":"2004","journal-title":"World J Gastroenterol"},{"key":"R9-2-20250207","doi-asserted-by":"crossref","first-page":"1669316703","DOI":"10.1074\/jbc.M109.055525","article-title":"RUNX3 modulates DNA damagemediated phosphorylation of tumor suppressor p53 at Ser15 and acts as a coactivator for p53.","volume":"285","author":"Yamada","year":"2010","journal-title":"J Biol Chem"},{"key":"R10-2-20250207","doi-asserted-by":"crossref","first-page":"149157","DOI":"10.1016\/j.yexcr.2009.09.025","article-title":"RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells.","volume":"316","author":"Gao","year":"2010","journal-title":"Exp Cell Res"},{"key":"R12-2-20250207","doi-asserted-by":"crossref","first-page":"10471055","DOI":"10.1016\/S0002-9440(10)65357-6","article-title":"Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing cMyc and transforming growth factoralpha in the liver.","volume":"154","author":"Sargent","year":"1999","journal-title":"Am J Pathol"},{"key":"R13-2-20250207","doi-asserted-by":"crossref","first-page":"660668","DOI":"10.1016\/j.jhep.2003.12.020","article-title":"Multiple chromosomal abnormalities in human liver (pre)neoplasia.","volume":"40","author":"Raidl","year":"2004","journal-title":"J Hepatol"},{"key":"R14-2-20250207","first-page":"19861990","article-title":"Concerted nonsyntenic allelic losses in hyperploid hepatocellular carcinoma as determined by a highresolution allelotype.","volume":"57","author":"Boige","year":"1997","journal-title":"Cancer Res"},{"key":"R15-2-20250207","doi-asserted-by":"crossref","first-page":"13061311","DOI":"10.1038\/ng1481","article-title":"Application of comparative functional genomics to identify bestfit mouse models to study human cancer.","volume":"36","author":"Lee","year":"2004","journal-title":"Nat Genet"},{"key":"R16-2-20250207","doi-asserted-by":"crossref","first-page":"10431048","DOI":"10.1038\/ng1861","article-title":"A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.","volume":"38","author":"Carter","year":"2006","journal-title":"Nat Genet"},{"key":"R17-2-20250207","doi-asserted-by":"crossref","first-page":"679687","DOI":"10.1136\/gut.2008.152652","article-title":"Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.","volume":"58","author":"Calvisi","year":"2009","journal-title":"Gut"},{"key":"R18-2-20250207","doi-asserted-by":"crossref","first-page":"10081016","DOI":"10.4161\/cbt.9.12.11710","article-title":"Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.","volume":"9","author":"Petrovic","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"R19-2-20250207","first-page":"25572576","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.","volume":"132","author":"ElSerag","year":"2007","journal-title":"Gastroenterology"},{"key":"R20-2-20250207","doi-asserted-by":"crossref","first-page":"12251245","DOI":"10.1517\/14728222.2010.526933","article-title":"Targeting oxidative stress in cancer.","volume":"14","author":"Lawless","year":"2010","journal-title":"Expert Opin Ther Targets"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.24205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201103000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T16:59:36Z","timestamp":1738947576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201103000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.24205","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}