{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:13Z","timestamp":1772118673935,"version":"3.50.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1523,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>\n                    <jats:bold>Abstract:<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Schistosoma haematobium<\/jats:italic>\n                      is responsible for two-thirds of the world's 200 million to 400 million cases of human schistosomiasis. It is a group 1 carcinogen and a leading cause of bladder cancer that occurs after years of chronic inflammation, fibrosis, and hyperproliferation in the host liver. The coevolution of blood flukes of the genus\n                      <jats:italic toggle=\"yes\">Schistosoma<\/jats:italic>\n                      and their human hosts is paradigmatic of long-term parasite development, survival, and maintenance in mammals. However, the contribution of host genes, especially those discrete from the immune system, necessary for parasite establishment and development remains poorly understood. This study investigated the role of metastasis-associated protein-1 gene (\n                      <jats:italic toggle=\"yes\">Mta1<\/jats:italic>\n                      ) product in the survival of\n                      <jats:italic toggle=\"yes\">S. haematobium<\/jats:italic>\n                      and productive infection in the host. Using a\n                      <jats:italic toggle=\"yes\">Mta\u22121<\/jats:italic>\n                      null mouse model, here we provide genetic evidence to suggest that MTA1 expression positively influences survival and\/or maturation of schistosomes in the host to patency, as we reproducibly recovered significantly fewer\n                      <jats:italic toggle=\"yes\">S. haematobium<\/jats:italic>\n                      worms and eggs from\n                      <jats:italic toggle=\"yes\">Mta1\u2212\/\u2212<\/jats:italic>\n                      mice than wild\u2212type mice. In addition, we found a distinct loss of cytokine interdependence and aberrant Th1 and Th2 cytokine responses in the\n                      <jats:italic toggle=\"yes\">Mta1\u2212\/\u2212<\/jats:italic>\n                      mice compared to age-matched wild-type mice. Thus, utilizing this\n                      <jats:italic toggle=\"yes\">Mta1<\/jats:italic>\n                      -null mouse model, we identified a distinct contribution of the mammalian MTA1 in establishing a productive host\u2013parasite interaction and thus revealed a host factor critical for the optimal survival of schistosomes and successful parasitism. Moreover, MTA1 appears to play a significant role in driving inflammatory responses to schistosome egg\u2013induced hepatic granulomata reactions, and thus offers a survival cue for parasitism as well as an obligatory contribution of liver in schistosomiasis.\n                      <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                      : These findings raise the possibility to develop intervention strategies targeting MTA1 to reduce the global burden of schistosomiasis, inflammation, and neoplasia. (HEPATOLOGY 2011;)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.24354","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T09:22:30Z","timestamp":1302600150000},"page":"285-295","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer"],"prefix":"10.1097","volume":"54","author":[{"given":"Sujit S.","family":"Nair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anitha","family":"Bommana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Bethony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda 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