{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:29:56Z","timestamp":1772465396011,"version":"3.50.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"abstract":"\n \n \n Based on the recently established role for the master coregulator MTA1 and MTA1-containing nuclear remodeling complexes in oncogenesis and inflammation, we explored the links between parasitism by the carcinogenic liver fluke<\/jats:bold>\n \n Opisthorchis viverrini\n <\/jats:bold>\n and this coregulator using both an<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n \u2212\/\u2212 mouse model of infection and a tissue microarray of liver fluke\u2013induced human cholangiocarcinomas (CCAs). Intense foci of inflammation and periductal fibrosis in the liver and kidneys of wild-type<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n +\/+ mice were evident at 23 days postinfection with<\/jats:bold>\n \n O. viverrini\n <\/jats:bold>\n . In contrast, little inflammatory response was observed in the same organs of infected<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n \u2212\/\u2212 mice. Livers of infected<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n +\/+ mice revealed strong up-regulation of fibrosis-associated markers such as cytokeratins 18 and 19 and annexin 2, as determined both by immunostaining and by reverse-transcription polymerase chain reaction compared with infected<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n \u2212\/\u2212 mice. CD4 expression was up-regulated by infection in the livers of both experimental groups; however, its levels were several-fold higher in the<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n +\/+ mice than in infected<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n \u2212\/\u2212 mice.<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n \u2212\/\u2212 infected mice also exhibited significantly higher systemic and hepatic levels of host cytokines such as interleukin (IL)-12p70, IL-10, and interferon-\u03b3 compared with the levels of these cytokines in the<\/jats:bold>\n \n Mta1\n <\/jats:bold>\n \n +\/+ mice, suggesting an essential role of MTA1 in the cross-regulation of the Th1 and Th2 responses, presumably due to chromatin remodeling of the target chromatin genes. Immunohistochemical analysis of \u2248300 liver tissue cores from confirmed cases of<\/jats:bold>\n \n O. viverrini\n <\/jats:bold>\n \u2013induced CCA showed that MTA1 expression was elevated in >80% of the specimens.<\/jats:bold>\n \n Conclusion\n <\/jats:bold>\n : These findings suggest that MTA1 status plays an important role in conferring an optimal cytokine response in mice following infection with<\/jats:bold>\n \n O. viverrini\n <\/jats:bold>\n and is a major player in parasite-induced CCA in humans. (Hepatology 2011;)<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.24518","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T11:16:53Z","timestamp":1309778213000},"page":"1388-1397","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans"],"prefix":"10.1097","volume":"54","author":[{"given":"Sujit S.","family":"Nair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anitha","family":"Bommana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh 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