{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:06:20Z","timestamp":1777622780408,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1308,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Along with twin and family studies, recent genome-wide association studies suggest that genetic factors contribute to the susceptibility and severity of primary biliary cirrhosis (PBC). Although several reports have demonstrated that the human leukocyte antigen (HLA)<\/jats:bold>\n                                 <jats:bold>\n                                    DRB1*08:03\n                                 <\/jats:bold>\n                                 <jats:bold>allele is associated with disease susceptibility in Japan, the precise analysis of HLA haplotypes and the role of amino acid alignment have not been fully clarified. We investigated HLA class I A, B, and C and HLA class II DRB1 and DQB1 alleles and haplotypes in 229 Japanese patients with PBC and compared them with the published data of 523 healthy subjects. Significant associations were found with PBC susceptibility for the<\/jats:bold>\n                                 <jats:bold>\n                                    DRB1*08:03-DQB1*06:01\n                                 <\/jats:bold>\n                                 <jats:bold>(13% versus 6%;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.000025; odds ratio [OR] = 2.22) and<\/jats:bold>\n                                 <jats:bold>\n                                    DRB1*04:05-DQB1*04:01\n                                 <\/jats:bold>\n                                 <jats:bold>haplotypes (17% versus 13%;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.044; OR = 1.38). Conversely, there were significant protective associations with the<\/jats:bold>\n                                 <jats:bold>\n                                    DRB1*13:02-DQB1*06:04\n                                 <\/jats:bold>\n                                 <jats:bold>(2% versus 5%;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.00093; OR = 0.27) and<\/jats:bold>\n                                 <jats:bold>\n                                    DRB1*11:01-DQB1*03:01\n                                 <\/jats:bold>\n                                 <jats:bold>haplotypes (1% versus 4%;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.03; OR = 0.37). The frequency of the<\/jats:bold>\n                                 <jats:bold>\n                                    DRB1*09:01-DQB1*03:03\n                                 <\/jats:bold>\n                                 <jats:bold>haplotype was significantly higher in patients who had received orthotopic liver transplantation (33% versus 11%;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.0012; OR = 3.96). Furthermore, the frequency of serine at position 57 (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.0000015; OR = 1.83) of the DR\u03b2chain differed the most in patients with PBC, compared with healthy subjects.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion :<\/jats:title>\n            <jats:p>\n                                 <jats:bold>This study established the role of HLA haplotypes in determining PBC susceptibility and progression in the Japanese population. Further resequencing of the HLA region is required to more precisely identify the genetic components of PBC. (Hepatology 2012)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.24705","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T02:59:10Z","timestamp":1317178750000},"page":"506-511","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":65,"title":["Human Leukocyte Antigen Class II Molecules Confer Both Susceptibility and Progression in Japanese Patients With Primary Biliary Cirrhosis"],"prefix":"10.1097","volume":"55","author":[{"given":"Takeji","family":"Umemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ichijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaname","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Katsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-19-20241201","doi-asserted-by":"crossref","first-page":"12611273","DOI":"10.1056\/NEJMra043898","article-title":"Primary 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