{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:24:06Z","timestamp":1784543046712,"version":"3.55.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1218,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>There are contrasting results in studies of cardiovascular risk in patients with genotype 1 chronic hepatitis C (G1 CHC). We evaluated the prevalence of carotid atherosclerosis compared with a control population in order to assess the potential association between atherosclerosis, host and viral factors, and liver histological features. In all, 174 consecutive biopsy-proven G1 CHC patients were evaluated by anthropometric and metabolic measurements and 174 patients attending an outpatient cardiology unit were used as controls. Intima-media thickness (IMT) and carotid plaques, defined as focal thickening of &gt;1.3 mm at the level of common carotid, were evaluated using ultrasonography. All G1 CHC biopsies were scored by one pathologist for staging and grading, and graded for steatosis. Carotid plaques were found in 73 (41.9%) G1 CHC patients compared with 40 (22.9%) control patients (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&lt; 0.001). Similarly, G1 CHC patients had a greater IMT compared with control patients (1.04 \u00b1 0.21 versus 0.90 \u00b1 0.16;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&lt; 0.001). Multivariate logistic regression analysis showed that older age (odds ratio [OR] 1.047, 95% confidence interval [CI]: 1.014-1.082,<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.005), and severe hepatic fibrosis (OR 2.177, 95% CI: 1.043-4.542,<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.03), were independently linked to the presence of carotid plaques. In patients \u226455 years, 15\/67 cases with F0-F2 fibrosis (22.3%) had carotid plaques, compared with 11\/21 (52.3%) with F3-F4 fibrosis (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.008). By contrast, in patients &gt;55 years the prevalence of carotid plaques was similar in those with or without severe fibrosis (25\/43, 58.1% versus 22\/43, 51.1%;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.51).<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>\n                                 <jats:bold>Severe hepatic fibrosis is associated with a high risk of early carotid atherosclerosis in G1 CHC patients. (Hepatology 2012)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.25508","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T06:08:39Z","timestamp":1322892519000},"page":"1317-1323","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":110,"title":["Carotid atherosclerosis and chronic hepatitis C: A prospective study of risk associations"],"prefix":"10.1097","volume":"55","author":[{"given":"Salvatore","family":"Petta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero","family":"Camm\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cabibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Licata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Marchesini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Mazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspare","family":"Parrinello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Novo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Licata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Crax\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20241201","doi-asserted-by":"crossref","first-page":"196203","DOI":"10.1093\/aje\/kwm061","article-title":"Hepatitis C virus infection and the development of type 2 diabetes in a communitybased longitudinal study.","volume":"166","author":"Wang","year":"2007","journal-title":"Am J Epidemiol"},{"key":"R2-2-20241201","doi-asserted-by":"crossref","first-page":"11361144","DOI":"10.1111\/j.1572-0241.2008.01813.x","article-title":"Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection.","volume":"103","author":"Petta","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"R3-2-20241201","doi-asserted-by":"crossref","first-page":"154352","DOI":"10.1002\/hep.23859","article-title":"Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1.","volume":"52","author":"Petta","year":"2010","journal-title":"HEPATOLOGY"},{"key":"R4-2-20241201","doi-asserted-by":"crossref","first-page":"648651","DOI":"10.1016\/j.jhep.2009.01.003","article-title":"Insulin resistance in HCV monoinfected and in HIVHCV coinfected patients: looking to the future.","volume":"50","author":"Camma","year":"2009","journal-title":"J Hepatol"},{"key":"R5-2-20241201","doi-asserted-by":"crossref","first-page":"293308","DOI":"10.1586\/eri.09.3","article-title":"Hepatitis C and diabetes: the inevitable coincidence?","volume":"7","author":"Lonardo","year":"2009","journal-title":"Expert Rev Anti Infect Ther"},{"key":"R7-2-20241201","doi-asserted-by":"crossref","first-page":"237244","DOI":"10.1111\/j.1365-2893.2010.01290.x","article-title":"Total and causespecific mortality rates in a prospective study of communityacquired hepatitis C virus infection in northern Norway.","volume":"18","author":"Kristiansen","year":"2011","journal-title":"J Viral Hepat"},{"key":"R8-2-20241201","doi-asserted-by":"crossref","first-page":"743750","DOI":"10.1093\/aje\/kwm370","article-title":"Increased allcause, liver, and cardiac mortality among hepatitis C virusseropositive blood 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American Diabetes Association: Clinical Practice Recommendations 2000 Committee Report.","volume":"23","year":"2000","journal-title":"Diabetes Care"},{"key":"R20-2-20241201","doi-asserted-by":"crossref","first-page":"412419","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"R21-2-20241201","doi-asserted-by":"crossref","first-page":"239244","DOI":"10.1016\/S0168-8278(03)00191-0","article-title":"Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease.","volume":"39","author":"Colloredo","year":"2003","journal-title":"J Hepatol"},{"key":"R22-2-20241201","doi-asserted-by":"crossref","first-page":"372374","DOI":"10.1016\/0168-8278(91)90084-O","article-title":"Classification of chronic viral hepatitis: a need for reassessment.","volume":"13","author":"Scheuer","year":"1991","journal-title":"J Hepatol"},{"key":"R24-2-20241201","doi-asserted-by":"crossref","first-page":"585589","DOI":"10.1002\/hep.510290240","article-title":"Hepatitis C virus RNA profiles in chronically infected individuals: do they relate to disease activity?","volume":"29","author":"Pontisso","year":"1999","journal-title":"HEPATOLOGY"},{"key":"R25-2-20241201","doi-asserted-by":"crossref","first-page":"428434","DOI":"10.1016\/S0168-8278(00)00036-2","article-title":"Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C.","volume":"34","author":"Serfaty","year":"2001","journal-title":"J Hepatol"},{"key":"R26-2-20241201","doi-asserted-by":"crossref","first-page":"17051711","DOI":"10.1161\/01.STR.23.12.1705","article-title":"Prevalence and determinants of carotid atherosclerosis in a general population.","volume":"23","author":"Prati","year":"1992","journal-title":"Stroke"},{"key":"R27-2-20241201","first-page":"11451151","article-title":"Prevalence and distribution of subclinical atherosclerosis by screening vascular ultrasound in low and intermediate risk adults: the New York physicians study.","volume":"22","author":"Postley","year":"2009","journal-title":"J Am Soc Echocardiogy"},{"key":"R29-2-20241201","doi-asserted-by":"crossref","first-page":"464468","DOI":"10.1161\/01.STR.0000111597.34179.47","article-title":"Wall shear stress is associated with intimamedia thickness and carotid atherosclerosis in subjects at low coronary heart disease risk.","volume":"35","author":"Irace","year":"2004","journal-title":"Stroke"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.25508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201205000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T13:34:23Z","timestamp":1733060063000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201205000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.25508","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}