{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:07:11Z","timestamp":1783368431073,"version":"3.54.6"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1187,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Sorting nexin (SNX) family proteins are best characterized for their abilities to regulate protein trafficking during processes such as endocytosis of membrane receptors, endosomal sorting, and protein degradation, but their<\/jats:bold>\n                                 <jats:bold>\n                                    in vivo\n                                 <\/jats:bold>\n                                 <jats:bold>functions remain largely unknown. We started to investigate the biological functions of SNXs using the zebrafish model. In this study, we demonstrated that SNX7 was essential for embryonic liver development. Hepatoblasts were specified normally, and the proliferation of these cells was not affected when SNX7 was knocked down by gene-specific morpholinos; however, they underwent massive apoptosis during the early budding stage. SNX7 mainly regulated the survival of cells in the embryonic liver and did not affect the viability of cells in other endoderm-derived organs. We further demonstrated that down-regulation of SNX7 by short interfering RNAs induced apoptosis in cell culture. At the molecular level, the cellular FLICE-like inhibitory protein (c-FLIP)\/caspase 8 pathway was activated when SNX7 was down-regulated. Furthermore, overexpression of c-FLIPS was able to rescue the SNX7 knockdown-induced liver defect.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>\n                                 <jats:bold>SNX7 is a liver-enriched antiapoptotic protein that is indispensable for the survival of hepatoblasts during zebrafish early embryogenesis.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.25560","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T06:51:28Z","timestamp":1324968688000},"page":"1985-1993","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish"],"prefix":"10.1097","volume":"55","author":[{"given":"Liangliang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanqing","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-35-20241201","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1126\/science.284.5422.1998","article-title":"Initiation of mammalian liver development from endoderm by fibroblast growth factors.","volume":"284","author":"Jung","year":"1999","journal-title":"Science"},{"key":"R2-35-20241201","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1101\/gad.904601","article-title":"Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.","volume":"15","author":"Rossi","year":"2001","journal-title":"Genes Dev"},{"key":"R3-35-20241201","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1242\/dev.001230","article-title":"Repression of Wntbetacatenin signaling in the anterior endoderm is essential for liver and pancreas development.","volume":"134","author":"McLin","year":"2007","journal-title":"Development"},{"key":"R4-35-20241201","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1174497","article-title":"Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.","volume":"324","author":"Wandzioch","year":"2009","journal-title":"Science"},{"key":"R5-35-20241201","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.1161431","article-title":"Generation and regeneration of cells of the liver and pancreas.","volume":"322","author":"Zaret","year":"2008","journal-title":"Science"},{"key":"R6-35-20241201","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.devcel.2010.01.011","article-title":"Organogenesis and development of the liver.","volume":"18","author":"SiTayeb","year":"2010","journal-title":"Dev Cell"},{"key":"R7-35-20241201","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/hep.23157","article-title":"New school in liver development: lessons from zebrafish.","volume":"50","author":"Chu","year":"2009","journal-title":"HEPATOLOGY"},{"key":"R8-35-20241201","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1673-8527(08)60121-6","article-title":"Liver development in zebrafish (Danio rerio).","volume":"36","author":"Tao","year":"2009","journal-title":"J Genet Genomics"},{"key":"R9-35-20241201","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1872-034X.2009.00522.x","article-title":"Liver development: lessons from knockout mice and mutant fish.","volume":"39","author":"Nakamura","year":"2009","journal-title":"Hepatol Res"},{"key":"R10-35-20241201","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0012-1606(02)00017-9","article-title":"Formation of the digestive system in zebrafish. 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