{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:40:22Z","timestamp":1790980822552,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1157,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program","doi-asserted-by":"crossref","award":["2008CB517401"],"award-info":[{"award-number":["2008CB517401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural and Science Foundation of China","doi-asserted-by":"crossref","award":["81030009"],"award-info":[{"award-number":["81030009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural and Science Foundation of China","doi-asserted-by":"crossref","award":["30971348"],"award-info":[{"award-number":["30971348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural and Science Foundation of China","doi-asserted-by":"crossref","award":["81170407"],"award-info":[{"award-number":["81170407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"crossref","award":["7102016"],"award-info":[{"award-number":["7102016"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Academic Human Resources Development in Institutions of Beijing Municipality","award":["PHR201006109"],"award-info":[{"award-number":["PHR201006109"]}]},{"DOI":"10.13039\/501100002888","name":"Beijing Municipal Commission of Education","doi-asserted-by":"crossref","award":["YB20101002501"],"award-info":[{"award-number":["YB20101002501"]}],"id":[{"id":"10.13039\/501100002888","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>15-Deoxy-\u0394<jats:sup>12,14<\/jats:sup>-Prostaglandin J<jats:sub>2<\/jats:sub> (15d-PGJ<jats:sub>2<\/jats:sub>), a natural peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) ligand, has been implicated as a new antiinflammatory compound with possible clinical applications. Based on this concept, this study was designed to evaluate the effects of 15d-PGJ<jats:sub>2<\/jats:sub> on bone marrow\u2013derived monocyte\/macrophage (BMM) migration, phagocytosis, and cytokine expression after liver injury using mouse models induced by cholestasis or carbon tetrachloride. Mice were lethally irradiated and received bone marrow transplants from enhanced green fluorescent protein transgenic mice. Our results showed that recruitment of BMM was significantly increased during chronic liver injury, and that 15d-PGJ<jats:sub>2<\/jats:sub> administration reduced BMM, but not neutrophil, dendritic, or T cell migration toward the damaged liver, involving reactive oxygen species generation and independently of PPAR-\u03b3. Moreover, 15d-PGJ<jats:sub>2<\/jats:sub> inhibited the phagocytic activity of BMM and down-regulated inflammatory cytokine expression <jats:italic toggle=\"yes\">in vivo<\/jats:italic> and <jats:italic toggle=\"yes\">in vitro<\/jats:italic>. Accordingly, hepatic inflammation and fibrosis were strikingly ameliorated after 15d-PGJ<jats:sub>2<\/jats:sub> administration. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Our findings strongly suggest the antiinflammation and antifibrogenic potential of 15d-PGJ<jats:sub>2<\/jats:sub> in chronic liver diseases. (HEPATOLOGY 2012;56:350\u2013360)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.25672","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T05:17:05Z","timestamp":1330406225000},"page":"350-360","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":43,"title":["15-deoxy-\u039412,14-prostaglandin J2 reduces recruitment of bone marrow\u2013derived monocyte\/macrophages in chronic liver injury in mice"],"prefix":"10.1097","volume":"56","author":[{"given":"Zhen","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-36-20241201","doi-asserted-by":"crossref","first-page":"209218","DOI":"10.1172\/JCI24282","article-title":"Liver 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