{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:01:58Z","timestamp":1777622518070,"version":"3.51.4"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":942,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Mice with a dominant-negative transforming growth factor \u03b2 receptor restricted to T cells (dnTGF\u03b2RII mice) develop an inflammatory biliary ductular disease that strongly resembles human primary biliary cirrhosis (PBC). Furthermore, deletion of the gene encoding interleukin (IL)-12p40 resulted in a strain (IL-12p40\u2212\/\u2212dnTGF\u03b2RII) with dramatically reduced autoimmune cholangitis. To further investigate the role of the IL-12 cytokine family in dnTGF\u03b2RII autoimmune biliary disease, we deleted the gene encoding the IL-12p35 subunit from dnTGF\u03b2RII mice, resulting in an IL-12p35\u2212\/\u2212 dnTGF\u03b2RII strain which is deficient in two members of the IL-12 family, IL-12 and IL-35. In contrast to IL-12p40\u2212\/\u2212 mice, the IL-12p35\u2212\/\u2212mice developed liver inflammation and bile duct damage with similar severity but delayed onset as the parental dnTGF\u03b2RII mice. The p35\u2212\/\u2212 mice also demonstrated a distinct cytokine profile characterized by a shift from a T-helper 1 (Th1) to a Th17 response. Strikingly, liver fibrosis was frequently observed in IL-12p35\u2212\/\u2212 mice. In conclusion, IL-12p35\u2212\/\u2212 dnTGF\u03b2RII mice, histologically and immunologically, reflect key features of PBC, providing a useful generic model to understand the immunopathology of human PBC.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.25829","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T11:52:07Z","timestamp":1336650727000},"page":"806-816","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":79,"title":["Deletion of Interleukin (IL)-12p35 Induces Liver Fibrosis in Dominant-Negative TGF\u03b2 Receptor Type II 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