{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:18:46Z","timestamp":1774664326558,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1034,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"\n \n \n Recently, genome-wide studies identified genetic variants that affect serum 25-hydroxyvitamin D levels in healthy populations (rs12785878, near dehydrocholesterol reductase,<\/jats:bold>\n \n DHCR7\n <\/jats:bold>\n ; rs10741657, at<\/jats:bold>\n \n CYP2R1\n <\/jats:bold>\n ; and rs7041, at vitamin D binding protein,<\/jats:bold>\n \n GC\n <\/jats:bold>\n ). Because vitamin D deficiency is associated with advanced liver disease, we hypothesized that these variants are associated with 25(OH)-vitamin D levels and liver fibrosis. Overall, 712 Caucasian patients with chronic liver diseases were included. Liver fibrosis was assessed by transient elastography (TE) and\/or histology. Serum levels of 25(OH)-vitamin D were correlated with TE and fibrosis stages. Genotypes were determined using TaqMan assays and tested for association with vitamin D and liver stiffness. Serum 25(OH)-vitamin D levels were inversely correlated with liver stiffness and histology (<\/jats:bold>\n \n P\n <\/jats:bold>\n < 0.001). Homozygous carriers of the rare<\/jats:bold>\n \n DHCR7\n <\/jats:bold>\n allele or the common<\/jats:bold>\n \n CYP2R1\n <\/jats:bold>\n allele presented with reduced 25(OH)-vitamin D levels (<\/jats:bold>\n \n P\n <\/jats:bold>\n < 0.05). The variant rs12785878 in the<\/jats:bold>\n \n DHCR7\n <\/jats:bold>\n locus was associated with liver stiffness in both patients with TE <7.0 kPa and TE between 7.0 and 9.5 kPa. 25(OH)-vitamin D levels correlated with sunshine hours at the time of inclusion (<\/jats:bold>\n \n P\n <\/jats:bold>\n < 0.001).<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Common variation in 25(OH)-vitamin D metabolism is associated with liver stiffness in patients presenting with low to moderately increased elasticity. Although the susceptible<\/jats:bold>\n \n DHCR7\n <\/jats:bold>\n genotype confers small risk, we speculate that the observed stiffness differences indicate a stronger influence of 25(OH)-vitamin D on initiation rather than progression of hepatic fibrosis.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.25830","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T11:52:07Z","timestamp":1336650727000},"page":"1883-1891","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":47,"title":["Common genetic variation in vitamin D metabolism is associated with liver stiffness"],"prefix":"10.1097","volume":"56","author":[{"given":"Frank","family":"Gr\u00fcnhage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hochrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Krawczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aksana","family":"H\u00f6blinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Obermayer-Pietsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Geisel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman","family":"Sauerbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-32-20241202","doi-asserted-by":"crossref","first-page":"254262","DOI":"10.1152\/ajplegacy.1969.216.2.254","article-title":"Role 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