{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:25:13Z","timestamp":1792038313287,"version":"4.4.0"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:bold>Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, the albumin molecule is susceptible to modifications that may alter its biological activity. During the last decades, different methods to measure albumin function have been developed. Recent studies have shown that not only albumin concentration but also albumin function is reduced in liver failure. This observation led to the concept of<\/jats:bold>\n                      <jats:bold>effective albumin concentration<\/jats:bold>\n                      <jats:bold>, which represents the fact that plasma albumin concentration does not reflect its function. Indeed, in liver disease albumin function is several times less than its concentration. In patients with cirrhosis, albumin infusion reduces mortality in patients with spontaneous bacterial peritonitis and improves outcome following large volume paracentesis. In combination with vasoconstrictors, albumin is useful in the management of patients with hepatorenal syndrome. Its role is being investigated in a large number of indications, which rely on its volume and nonvolume expansion functions such as stroke, severe sepsis, Alzheimer's disease, malaria, burns, and ovarian hyperstimulation syndrome. This review explores the above concepts, reviews the available evidence for the use of albumin in liver diseases, defines therapeutic limitations, and explores the challenges that should be addressed in future research. (Hepatology 2013;58:1836\u20131846)<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.26338","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T14:56:52Z","timestamp":1361285812000},"page":"1836-1846","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":416,"title":["Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications"],"prefix":"10.1097","volume":"58","author":[{"given":"Rita","family":"Garcia-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Caraceni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Gines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Jalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-32-20241201","doi-asserted-by":"crossref","first-page":"405409","DOI":"10.1016\/j.bbrc.2003.07.016","article-title":"Branchedchain amino acids as a protein and energysource in liver cirrhosis.","volume":"313","author":"Moriwaki","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R3-32-20241201","doi-asserted-by":"crossref","first-page":"12111219","DOI":"10.1002\/hep.20720","article-title":"Albumin: biochemical properties and therapeutic potential.","volume":"41","author":"Quinlan","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R5-32-20241201","doi-asserted-by":"crossref","first-page":"209215","DOI":"10.1038\/358209a0","article-title":"Atomic structure and chemistry of human serum albumin.","volume":"358","author":"He","year":"1992","journal-title":"Nature"},{"key":"R6-32-20241201","first-page":"695704","article-title":"Practical aspects of the ligandbinding and enzymatic properties of human serum albumin.","volume":"25","author":"KraghHansen","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"R7-32-20241201","doi-asserted-by":"crossref","first-page":"15541561","DOI":"10.1111\/j.1523-1755.2005.00567.x","article-title":"Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy.","volume":"68","author":"Cohen","year":"2005","journal-title":"Kidney Int"},{"key":"R8-32-20241201","doi-asserted-by":"crossref","first-page":"527534","DOI":"10.1248\/bpb.32.527","article-title":"Pharmaceutically important pre and posttranslational modifications on human serum albumin.","volume":"32","author":"Otagiri","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"R10-32-20241201","doi-asserted-by":"crossref","first-page":"4292442928","DOI":"10.1074\/jbc.M406957200","article-title":"Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin.","volume":"279","author":"Lejon","year":"2004","journal-title":"J Biol Chem"},{"key":"R11-32-20241201","doi-asserted-by":"crossref","first-page":"445451","DOI":"10.1042\/cs0930445","article-title":"Ironbinding antioxidant potential of plasma albumin.","volume":"93","author":"Loban","year":"1997","journal-title":"Clin Sci (Lond)"},{"key":"R12-32-20241201","doi-asserted-by":"crossref","first-page":"59185922","DOI":"10.1073\/pnas.84.16.5918","article-title":"Antioxidant activity of albuminbound bilirubin.","volume":"84","author":"Stocker","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-32-20241201","doi-asserted-by":"crossref","first-page":"831840","DOI":"10.1002\/hep.21737","article-title":"Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome.","volume":"46","author":"Mookerjee","year":"2007","journal-title":"HEPATOLOGY"},{"key":"R14-32-20241201","doi-asserted-by":"crossref","first-page":"G15G22","DOI":"10.1152\/ajpgi.90512.2008","article-title":"Role of Tolllike receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis.","volume":"296","author":"Stadlbauer","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R15-32-20241201","doi-asserted-by":"crossref","first-page":"15091513","DOI":"10.1016\/j.febslet.2007.03.008","article-title":"Carbamylated albumin is a potent inhibitor of polymorphonuclear neutrophil respiratory burst.","volume":"581","author":"Jaisson","year":"2007","journal-title":"FEBS Lett"},{"key":"R17-32-20241201","doi-asserted-by":"crossref","first-page":"820829","DOI":"10.1016\/S0008-6363(02)00492-3","article-title":"Albumin selectively inhibits TNF alphainduced expression of vascular cell adhesion molecule1 in human aortic endothelial cells.","volume":"55","author":"Zhang","year":"2002","journal-title":"Cardiovasc Res"},{"key":"R18-32-20241201","doi-asserted-by":"crossref","first-page":"619625","DOI":"10.1080\/00365520902719273","article-title":"Effect of intravenous albumin on endotoxin removal, cytokines, and nitric oxide production in patients with cirrhosis and spontaneous bacterial peritonitis.","volume":"44","author":"Chen","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"R19-32-20241201","doi-asserted-by":"crossref","first-page":"386391","DOI":"10.1097\/CCM.0b013e3181ffe217","article-title":"The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and metaanalysis.","volume":"39","author":"Delaney","year":"2011","journal-title":"Crit Care Med"},{"key":"R21-32-20241201","doi-asserted-by":"crossref","first-page":"312317","DOI":"10.1016\/S0272-6386(99)70306-9","article-title":"Effect of increasing serum albumin on plasma Ddimer, von Willebrand factor, and platelet aggregation in CAPD patients.","volume":"33","author":"Kim","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"R22-32-20241201","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1097\/00000542-200401000-00012","article-title":"Albumin and hydroxyethyl starch modulate oxidative inflammatory injury to vascular endothelium.","volume":"100","author":"Lang","year":"2004","journal-title":"Anesthesiology"},{"key":"R23-32-20241201","doi-asserted-by":"crossref","first-page":"627634","DOI":"10.1002\/hep.20829","article-title":"A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis.","volume":"42","author":"Fernandez","year":"2005","journal-title":"HEPATOLOGY"},{"key":"R24-32-20241201","doi-asserted-by":"crossref","first-page":"13331339","DOI":"10.1002\/lt.21504","article-title":"Improvement of impaired albumin binding capacity in acuteonchronic liver failure by albumin dialysis.","volume":"14","author":"Klammt","year":"2008","journal-title":"Liver Transpl"},{"key":"R25-32-20241201","doi-asserted-by":"crossref","first-page":"23772383","DOI":"10.1093\/ndt\/gfr616","article-title":"Albuminbinding capacity (ABiC) is reduced in patients with chronic kidney disease along with an accumulation of proteinbound uraemic toxins.","volume":"27","author":"Klammt","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"R26-32-20241201","doi-asserted-by":"crossref","first-page":"87558759","DOI":"10.1002\/anie.201003495","article-title":"The distribution of fatty acids reveals the functional structure of human serum albumin.","volume":"49","author":"Junk","year":"2010","journal-title":"Angew Chem Int Ed Engl"},{"key":"R27-32-20241201","doi-asserted-by":"crossref","first-page":"555564","DOI":"10.1002\/hep.22913","article-title":"Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality.","volume":"50","author":"Jalan","year":"2009","journal-title":"HEPATOLOGY"},{"key":"R28-32-20241201","doi-asserted-by":"crossref","first-page":"21292134","DOI":"10.1373\/clinchem.2006.073148","article-title":"Electron spin resonance spectroscopy of serum albumin: a novel new test for cancer diagnosis and monitoring.","volume":"52","author":"Kazmierczak","year":"2006","journal-title":"Clin Chem"},{"key":"R29-32-20241201","doi-asserted-by":"crossref","first-page":"12031210","DOI":"10.1515\/CCLM.2008.260","article-title":"Application of spin label electron paramagnetic resonance in the diagnosis and prognosis of cancer and sepsis.","volume":"46","author":"Gurachevsky","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"R30-32-20241201","first-page":"311315","article-title":"A novel assay for cobaltalbumin binding and its potential as a marker for myocardial ischemiaa preliminary report.","volume":"19","author":"BarOr","year":"2000","journal-title":"J Emerg Med"},{"key":"R31-32-20241201","doi-asserted-by":"crossref","first-page":"216220","DOI":"10.1159\/000097644","article-title":"Ischemiamodified albumin in acute stroke.","volume":"23","author":"Abboud","year":"2007","journal-title":"Cerebrovasc Dis"},{"key":"R32-32-20241201","doi-asserted-by":"crossref","first-page":"202205","DOI":"10.1016\/j.ajem.2007.04.030","article-title":"Ischemiamodified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study.","volume":"26","author":"Gunduz","year":"2008","journal-title":"Am J Emerg Med"},{"key":"R33-32-20241201","doi-asserted-by":"crossref","first-page":"570576","DOI":"10.1007\/s12020-012-9652-9","article-title":"Increased serum levels of ischemiamodified albumin and Creactive protein in type 1 diabetes patients with ketoacidosis.","volume":"42","author":"Ma","year":"2012","journal-title":"Endocrine"},{"key":"R34-32-20241201","doi-asserted-by":"crossref","first-page":"226232","DOI":"10.5301\/ijao.5000078","article-title":"Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemiamodified albumin.","volume":"35","author":"Mehmetoglu","year":"2012","journal-title":"Int J Artif Organs"},{"key":"R35-32-20241201","doi-asserted-by":"crossref","first-page":"24032405","DOI":"10.1161\/01.CIR.0000072764.18315.6B","article-title":"Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention.","volume":"107","author":"Sinha","year":"2003","journal-title":"Circulation"},{"key":"R36-32-20241201","doi-asserted-by":"crossref","first-page":"19881993","DOI":"10.1111\/j.1523-1755.2004.00969.x","article-title":"Oxidative stress is enhanced in correlation with renal dysfunction: examination with the redox state of albumin.","volume":"66","author":"Terawaki","year":"2004","journal-title":"Kidney Int"},{"key":"R37-32-20241201","first-page":"469473","article-title":"Oxidative damage of albumin in advanced liver disease.","volume":"1782","author":"Oettl","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"R38-32-20241201","doi-asserted-by":"crossref","first-page":"13221328","DOI":"10.1016\/j.bbrc.2005.07.035","article-title":"The structure and function of oxidized albumin in hemodialysis patients: its role in elevated oxidative stress via neutrophil burst.","volume":"334","author":"Mera","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R39-32-20241201","doi-asserted-by":"crossref","first-page":"580590","DOI":"10.1038\/sj.bjp.0707251","article-title":"Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties.","volume":"151","author":"Oettl","year":"2007","journal-title":"Br J Pharmacol"},{"key":"R40-32-20241201","doi-asserted-by":"crossref","first-page":"14031407","DOI":"10.3748\/wjg.v12.i9.1403","article-title":"Longterm albumin infusion improves survival in patients with cirrhosis and ascites: an unblinded randomized trial.","volume":"12","author":"Romanelli","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R41-32-20241201","first-page":"22472256","article-title":"A comparison of albumin and saline for fluid resuscitation in the intensive care unit.","volume":"350","author":"Finfer","year":"2004","journal-title":"N Engl J Med"},{"key":"R42-32-20241201","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.7326\/0003-4819-121-1-199407010-00005","article-title":"Neurohormonal and hemodynamic changes in severe cases of the ovarian hyperstimulation syndrome.","volume":"121","author":"Balasch","year":"1994","journal-title":"Ann Intern Med"},{"key":"R43-32-20241201","doi-asserted-by":"crossref","first-page":"538545","DOI":"10.1086\/427505","article-title":"Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit.","volume":"40","author":"Maitland","year":"2005","journal-title":"Clin Infect Dis"},{"key":"R44-32-20241201","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.burns.2006.10.005","article-title":"Burn patient characteristics and outcomes following resuscitation with albumin.","volume":"33","author":"Cochran","year":"2007","journal-title":"Burns"},{"key":"R45-32-20241201","doi-asserted-by":"crossref","first-page":"21072114","DOI":"10.1161\/01.STR.0000231389.34701.b5","article-title":"The ALIAS Pilot Trial: a doseescalation and safety study of albumin therapy for acute ischemic stroke. II: Neurologic outcome and efficacy analysis.","volume":"37","author":"Palesch","year":"2006","journal-title":"Stroke"},{"key":"R46-32-20241201","doi-asserted-by":"crossref","first-page":"870878","DOI":"10.1007\/s00415-006-0456-9","article-title":"Albumin therapy in acute stroke patients.","volume":"254","author":"Shin","year":"2007","journal-title":"J Neurol"},{"key":"R47-32-20241201","doi-asserted-by":"crossref","first-page":"325339","DOI":"10.1358\/dnp.2009.22.6.1395256","article-title":"Amyloidtargeted therapeutics in Alzheimers disease: use of human albumin in plasma exchange as a novel approach for Abeta mobilization.","volume":"22","author":"Boada","year":"2009","journal-title":"Drug News Perspect"},{"key":"R48-32-20241201","doi-asserted-by":"crossref","first-page":"17151728","DOI":"10.1053\/j.gastro.2008.03.007","article-title":"Portal hypertension and its complications.","volume":"134","author":"Sanyal","year":"2008","journal-title":"Gastroenterology"},{"issue":"Suppl 5","key":"R49-32-20241201","first-page":"15","article-title":"Review article: albumin in the treatment of liver diseasesnew features of a classical treatment.","volume":"16","author":"Arroyo","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"R50-32-20241201","first-page":"397417","article-title":"EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis.","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"R51-32-20241201","doi-asserted-by":"crossref","first-page":"20872107","DOI":"10.1002\/hep.22853","article-title":"Management of adult patients with ascites due to cirrhosis: an update.","volume":"49","author":"Runyon","year":"2009","journal-title":"HEPATOLOGY"},{"key":"R52-32-20241201","doi-asserted-by":"crossref","first-page":"403409","DOI":"10.1056\/NEJM199908053410603","article-title":"Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis.","volume":"341","author":"Sort","year":"1999","journal-title":"N Engl J Med"},{"key":"R53-32-20241201","doi-asserted-by":"crossref","first-page":"384390","DOI":"10.1016\/j.jhep.2004.05.009","article-title":"Effect of intravenous albumin on systemic and hepatic hemodynamics and vasoactive neurohormonal systems in patients with cirrhosis and spontaneous bacterial peritonitis.","volume":"41","author":"Fernandez","year":"2004","journal-title":"J Hepatol"},{"key":"R54-32-20241201","doi-asserted-by":"crossref","first-page":"12151222","DOI":"10.1111\/j.1440-1746.2005.03861.x","article-title":"Longterm clinical outcome of large volume paracentesis with intravenous albumin in patients with spontaneous bacterial peritonitis: a randomized prospective study.","volume":"20","author":"Choi","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"R55-32-20241201","doi-asserted-by":"crossref","first-page":"597599","DOI":"10.1136\/gut.2006.113050","article-title":"Restricted use of albumin for spontaneous bacterial peritonitis.","volume":"56","author":"Sigal","year":"2007","journal-title":"Gut"},{"key":"R56-32-20241201","first-page":"13711372","article-title":"Lowdose albumin in the treatment of spontaneous bacterial peritonitis: should we change the standard treatment?","volume":"61","author":"de AA, de Barros","year":"2012","journal-title":"Gut"},{"key":"R57-32-20241201","doi-asserted-by":"crossref","first-page":"309315","DOI":"10.1016\/j.cgh.2011.11.012","article-title":"Role of albumin treatment in patients with spontaneous bacterial peritonitis.","volume":"10","author":"Poca","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R58-32-20241201","doi-asserted-by":"crossref","first-page":"123130","DOI":"10.1016\/j.cgh.2012.11.007","article-title":"Albumin Infusion improves outcomes of patients with spontaneous bacterial peritonitis: a metaanalysis of randomized trials.","volume":"11","author":"Salerno","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R59-32-20241201","doi-asserted-by":"crossref","first-page":"179190","DOI":"10.1016\/j.jhep.2010.02.023","article-title":"Cirrhotic cardiomyopathy.","volume":"53","author":"Moller","year":"2010","journal-title":"J Hepatol"},{"key":"R60-32-20241201","doi-asserted-by":"crossref","first-page":"14051417","DOI":"10.1517\/14656566.2011.561200","article-title":"Hepatorenal syndrome.","volume":"12","author":"Guevara","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"R62-32-20241201","doi-asserted-by":"crossref","first-page":"830835","DOI":"10.1007\/s10620-007-9919-9","article-title":"Terlipressin and albumin in patients with cirrhosis and type I hepatorenal syndrome.","volume":"53","author":"Neri","year":"2008","journal-title":"Dig Dis Sci"},{"key":"R63-32-20241201","doi-asserted-by":"crossref","first-page":"13601368","DOI":"10.1053\/j.gastro.2008.02.014","article-title":"A randomized, prospective, doubleblind, placebocontrolled trial of terlipressin for type 1 hepatorenal syndrome.","volume":"134","author":"Sanyal","year":"2008","journal-title":"Gastroenterology"},{"key":"R64-32-20241201","first-page":"13521359","article-title":"Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study.","volume":"134","author":"MartinLlahi","year":"2008","journal-title":"Gastroenterology"},{"key":"R65-32-20241201","doi-asserted-by":"crossref","first-page":"266276","DOI":"10.1002\/hep.26021","article-title":"Positive cardiac inotropic effect of albumin infusion in rats with cirrhosis and ascites: molecular mechanisms.","volume":"57","author":"Bortoluzzi","year":"2013","journal-title":"HEPATOLOGY"},{"key":"R66-32-20241201","doi-asserted-by":"crossref","first-page":"14931502","DOI":"10.1016\/0016-5085(88)90691-9","article-title":"Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis.","volume":"94","author":"Gines","year":"1988","journal-title":"Gastroenterology"},{"key":"R67-32-20241201","doi-asserted-by":"crossref","first-page":"11721181","DOI":"10.1002\/hep.24786","article-title":"Albumin infusion in patients undergoing largevolume paracentesis: a metaanalysis of randomized trials.","volume":"55","author":"Bernardi","year":"2012","journal-title":"HEPATOLOGY"},{"key":"R68-32-20241201","doi-asserted-by":"crossref","first-page":"467474","DOI":"10.1042\/CS20030357","article-title":"Reversal of diureticinduced hepatic encephalopathy with infusion of albumin but not colloid.","volume":"106","author":"Jalan","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"R69-32-20241201","doi-asserted-by":"crossref","first-page":"18531862","DOI":"10.1002\/hep.21930","article-title":"Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis.","volume":"46","author":"Hassanein","year":"2007","journal-title":"HEPATOLOGY"},{"key":"R70-32-20241201","doi-asserted-by":"crossref","first-page":"759765","DOI":"10.1016\/j.jhep.2012.06.013","article-title":"Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study.","volume":"57","author":"Guevara","year":"2012","journal-title":"J Hepatol"},{"key":"R71-32-20241201","doi-asserted-by":"crossref","first-page":"18641872","DOI":"10.1002\/hep.24622","article-title":"Intensive care of the patient with cirrhosis.","volume":"54","author":"Olson","year":"2011","journal-title":"HEPATOLOGY"},{"key":"R72-32-20241201","doi-asserted-by":"crossref","first-page":"142148","DOI":"10.1016\/j.jhep.2005.01.032","article-title":"Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis.","volume":"43","author":"Sen","year":"2005","journal-title":"J Hepatol"},{"key":"R73-32-20241201","doi-asserted-by":"crossref","first-page":"R108","DOI":"10.1186\/cc4985","article-title":"Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acuteonchronic alcoholic liver failure.","volume":"10","author":"Laleman","year":"2006","journal-title":"Crit Care"},{"key":"R74-32-20241201","first-page":"377A","article-title":"Randomized controlled multicenter trial evaluating the efficacy and safety of albumin dialysis with MARS in patients with fuminant and subfulminant hepatic failure Abstract.","volume":"48","author":"Saliba","year":"2008","journal-title":"HEPATOLOGY"},{"key":"R76-32-20241201","doi-asserted-by":"crossref","first-page":"782789","DOI":"10.1053\/j.gastro.2011.12.056","article-title":"Effects of fractionated plasma separation and adsorption on survival in patients with acuteonchronic liver failure.","volume":"142","author":"Kribben","year":"2012","journal-title":"Gastroenterology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.26338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.26338","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201311000-00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T09:14:58Z","timestamp":1733044498000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201311000-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.26338","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}