{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:19:29Z","timestamp":1791285569528,"version":"4.1.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":281,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Identification of microRNAs (miRNAs) that regulate lipid metabolism is important to advance the understanding and treatment of some of the most common human diseases. In the liver, a few key miRNAs have been reported that regulate lipid metabolism, but since many genes contribute to hepatic lipid metabolism, we hypothesized that other such miRNAs exist. To identify genes repressed by miRNAs in mature hepatocytes <jats:italic toggle=\"yes\">in vivo<\/jats:italic>, we injected adult mice carrying floxed <jats:italic toggle=\"yes\">Dicer1<\/jats:italic> alleles with an adenoassociated viral vector expressing Cre recombinase specifically in hepatocytes. By inactivating Dicer in adult quiescent hepatocytes we avoided the hepatocyte injury and regeneration observed in previous mouse models of global miRNA deficiency in hepatocytes. Next, we combined gene and miRNA expression profiling to identify candidate gene\/miRNA interactions involved in hepatic lipid metabolism and validated their function <jats:italic toggle=\"yes\">in vivo<\/jats:italic> using antisense oligonucleotides. A candidate gene that emerged from our screen was lipoprotein lipase (<jats:italic toggle=\"yes\">Lpl<\/jats:italic>), which encodes an enzyme that facilitates cellular uptake of lipids from the circulation. Unlike in energy\u2010dependent cells like myocytes, LPL is normally repressed in adult hepatocytes. We identified miR\u201029a as the miRNA responsible for repressing LPL in hepatocytes, and found that decreasing hepatic miR\u201029a levels causes lipids to accumulate in mouse livers. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Our screen suggests several new miRNAs are regulators of hepatic lipid metabolism. We show that one of these, miR\u201029a, contributes to physiological lipid distribution away from the liver and protects hepatocytes from steatosis. Our results, together with miR\u201029a's known antifibrotic effect, suggest miR\u201029a is a therapeutic target in fatty liver disease. (H<jats:sc>epatology<\/jats:sc> 2015;61:141\u2013152)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.27379","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T08:10:07Z","timestamp":1408349407000},"page":"141-152","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":59,"title":["A screen in mice uncovers repression of lipoprotein lipase by microRNA\u201029a as a mechanism for lipid distribution away from the liver"],"prefix":"10.1097","volume":"61","author":[{"given":"Aras N.","family":"Mattis","sequence":"first","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"},{"name":"Department of Pathology,University of California San Francisco,San Francisco,CA"},{"name":"Liver Center,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisheng","family":"Song","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Hitchner","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"San Francisco VA Medical Center,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar D.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Malato","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"},{"name":"Department of Surgery, Division of Transplantation,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"McManus","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology,University of California San Francisco,San Francisco,CA"},{"name":"Diabetes Center,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine C.","family":"Esau","sequence":"additional","affiliation":[{"name":"Regulus Therapeutics,San Diego,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Koller","sequence":"additional","affiliation":[{"name":"Isis Pharmaceuticals,Carlsbad,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneil","family":"Koliwad","sequence":"additional","affiliation":[{"name":"Liver Center,University of California San Francisco,San Francisco,CA"},{"name":"Diabetes Center,University of California San Francisco,San Francisco,CA"},{"name":"Department of Medicine, Division of Endocrinology,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee P.","family":"Lim","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn J.","family":"Maher","sequence":"additional","affiliation":[{"name":"Liver Center,University of California San Francisco,San Francisco,CA"},{"name":"Department of Medicine, Division of Gastroenterology,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Raffai","sequence":"additional","affiliation":[{"name":"San Francisco VA Medical Center,San Francisco,CA"},{"name":"Department of Surgery, Division of Vascular Surgery,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Willenbring","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research,University of California San Francisco,San Francisco,CA"},{"name":"Liver Center,University of California San Francisco,San Francisco,CA"},{"name":"Department of Surgery, Division of Transplantation,University of California San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"hep27379-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrm3313","article-title":"MicroRNAs in metabolism and metabolic disorders","volume":"13","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"hep27379-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MOL.0b013e3283534c9f","article-title":"MicroRNAs: emerging roles in lipid and lipoprotein metabolism","volume":"23","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"hep27379-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","article-title":"Identification of tissue\u2010specific microRNAs from mouse","volume":"12","year":"2002","journal-title":"Curr Biol"},{"key":"hep27379-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs.\u2019","volume":"438","year":"2005","journal-title":"Nature"},{"key":"hep27379-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"miR\u2010122 regulation of lipid metabolism revealed by in vivo antisense targeting","volume":"3","year":"2006","journal-title":"Cell Metab"},{"key":"hep27379-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1172\/JCI63455","article-title":"MicroRNA\u2010122 plays a critical role in liver homeostasis and hepatocarcinogenesis","volume":"122","year":"2012","journal-title":"J Clin Invest"},{"key":"hep27379-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1172\/JCI63539","article-title":"Essential metabolic, anti\u2010inflammatory, and anti\u2010tumorigenic functions of miR\u2010122 in liver","volume":"122","year":"2012","journal-title":"J Clin Invest"},{"key":"hep27379-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1189123","article-title":"MicroRNA\u201033 and the SREBP host genes cooperate to control cholesterol homeostasis","volume":"328","year":"2010","journal-title":"Science"},{"key":"hep27379-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","year":"2005","journal-title":"Cell"},{"key":"hep27379-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1073\/pnas.0504834102","article-title":"The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"hep27379-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V","article-title":"DNA excision in liver by an albumin\u2010Cre transgene occurs progressively with age","volume":"26","year":"2000","journal-title":"Genesis"},{"key":"hep27379-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1172\/JCI59261","article-title":"Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration","volume":"121","year":"2011","journal-title":"J Clin Invest"},{"key":"hep27379-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"11587","DOI":"10.1073\/pnas.201279298","article-title":"Introduction of human apolipoprotein E4 \"domain interaction\" into mouse apolipoprotein E","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"hep27379-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"G1578","DOI":"10.1152\/ajpgi.00359.2006","article-title":"beta\u2010Catenin is critical for early postnatal liver growth","volume":"292","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep27379-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/hep.22656","article-title":"Hepatic function is preserved in the absence of mature microRNAs","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"hep27379-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1053\/j.gastro.2009.02.067","article-title":"Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis","volume":"136","year":"2009","journal-title":"Gastroenterology"},{"key":"hep27379-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/hep.23547","article-title":"MicroRNAs control hepatocyte proliferation during liver regeneration","volume":"51","year":"2010","journal-title":"Hepatology"},{"key":"hep27379-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","year":"2007","journal-title":"Cell"},{"key":"hep27379-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nature06783","article-title":"LNA\u2010mediated microRNA silencing in non\u2010human primates","volume":"452","year":"2008","journal-title":"Nature"},{"key":"hep27379-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0955-0674(03)00002-4","article-title":"Oxidant signals and oxidative stress","volume":"15","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"hep27379-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/nar\/gkm1113","article-title":"Antagonism of microRNA\u2010122 in mice by systemically administered LNA\u2010antimiR leads to up\u2010regulation of a large set of predicted target mRNAs in the liver","volume":"36","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"hep27379-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","year":"2008","journal-title":"Nature"},{"key":"hep27379-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/msb.2011.23","article-title":"Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques","volume":"7","year":"2011","journal-title":"Mol Syst Biol"},{"key":"hep27379-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MCO.0b013e328342991c","article-title":"Fatty acid regulation of hepatic lipid metabolism","volume":"14","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"hep27379-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/MOL.0b013e32834d0b33","article-title":"New wrinkles in lipoprotein lipase biology","volume":"23","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"hep27379-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0167-4781(92)90026-V","article-title":"Neonatal extinction of liver lipoprotein lipase expression","volume":"1131","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"hep27379-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00041433-200210000-00002","article-title":"Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism","volume":"13","year":"2002","journal-title":"Curr Opin Lipidol"},{"key":"hep27379-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.1152\/ajpendo.90920.2008","article-title":"Lipoprotein lipase: from gene to obesity","volume":"297","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"hep27379-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/nar\/gkn904","article-title":"Potent inhibition of microRNA in vivo without degradation","volume":"37","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"hep27379-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.taap.2012.02.012","article-title":"Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR\u201024","volume":"260","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"hep27379-bib-0031-20241017","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro\u2010RNA profiling reveals a role for miR\u201029 in human and murine liver fibrosis","volume":"53","year":"2011","journal-title":"Hepatology"},{"key":"hep27379-bib-0032-20241017","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1152\/physiolgenomics.00141.2011","article-title":"The miR\u201029 family: genomics, cell biology, and relevance to renal and cardiovascular injury","volume":"44","year":"2012","journal-title":"Physiol Genomics"},{"key":"hep27379-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1172\/JCI36066","article-title":"DGAT1\u2010dependent triacylglycerol storage by macrophages protects mice from diet\u2010induced insulin resistance and inflammation","volume":"120","year":"2010","journal-title":"J Clin Invest"},{"key":"hep27379-bib-0034-20241017","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm.1937","article-title":"Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase\u20102 protects mice from metabolic disorders induced by high\u2010fat feeding","volume":"15","year":"2009","journal-title":"Nat Med"},{"key":"hep27379-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0022-2275(20)32514-1","article-title":"Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein\u2010associated cholesteryl esters by hepatic cells in culture","volume":"39","year":"1998","journal-title":"J Lipid Res"},{"key":"hep27379-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1194\/jlr.M600292-JLR200","article-title":"Lipoprotein lipase\u2010facilitated uptake of LDL is mediated by the LDL receptor","volume":"48","year":"2007","journal-title":"J Lipid Res"},{"key":"hep27379-bib-0037-20241017","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1172\/JCI2912","article-title":"Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia","volume":"102","year":"1998","journal-title":"J Clin Invest"},{"key":"hep27379-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.atherosclerosis.2011.05.014","article-title":"Liver transcriptional profile of atherosclerosis\u2010related genes in human nonalcoholic fatty liver disease","volume":"218","year":"2011","journal-title":"Atherosclerosis"},{"key":"hep27379-bib-0039-20241017","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/db07-0156","article-title":"Genes involved in fatty acid partitioning and binding, lipolysis, monocyte\/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin\u2010resistant subjects","volume":"56","year":"2007","journal-title":"Diabetes"},{"key":"hep27379-bib-0040-20241017","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s11695-009-9827-5","article-title":"Lipoprotein lipase expression in livers of morbidly obese patients could be responsible for liver steatosis","volume":"19","year":"2009","journal-title":"Obes Surg"},{"key":"hep27379-bib-0041-20241017","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1083\/jcb.200802105","article-title":"Loss of miRNA biogenesis induces p19Arf\u2010p53 signaling and senescence in primary cells","volume":"181","year":"2008","journal-title":"J Cell Biol"},{"key":"hep27379-bib-0042-20241017","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2013.06.010","article-title":"An SREBP\u2010responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis","volume":"18","year":"2013","journal-title":"Cell Metab"},{"key":"hep27379-bib-0043-20241017","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nm.3200","article-title":"MicroRNA\u201030c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion","volume":"19","year":"2013","journal-title":"Nat Med"},{"key":"hep27379-bib-0044-20241017","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2008.01.016","article-title":"Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non\u2010alcoholic fatty liver disease","volume":"48","year":"2008","journal-title":"J Hepatol"},{"key":"hep27379-bib-0045-20241017","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.dld.2008.08.008","article-title":"MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease","volume":"41","year":"2009","journal-title":"Dig Liver Dis"},{"key":"hep27379-bib-0046-20241017","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1194\/jlr.M800509-JLR200","article-title":"Differential expression of microRNAs in mouse liver under aberrant energy metabolic status","volume":"50","year":"2009","journal-title":"J Lipid Res"},{"key":"hep27379-bib-0047-20241017","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/labinvest.2010.113","article-title":"Difference in expression of hepatic microRNAs miR\u201029c, miR\u201034a, miR\u2010155, and miR\u2010200b is associated with strain\u2010specific susceptibility to dietary nonalcoholic steatohepatitis in mice","volume":"90","year":"2010","journal-title":"Lab Invest"},{"key":"hep27379-bib-0048-20241017","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.atherosclerosis.2014.02.008","article-title":"MicroRNA\u201027a\/b regulates cellular cholesterol efflux, influx and esterification\/hydrolysis in THP\u20101 macrophages","volume":"234","year":"2014","journal-title":"Atherosclerosis"},{"key":"hep27379-bib-0049-20241017","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.25846","article-title":"MicroRNA\u201027b is a regulatory hub in lipid metabolism and is altered in dyslipidemia","volume":"57","year":"2013","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.27379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201501000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:50:07Z","timestamp":1729212607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201501000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.27379","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,24]]},"assertion":[{"value":"2014-02-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}