{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:39:15Z","timestamp":1792276755727,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":239,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Association Fran\u00c3\u00a7aise pour l'Etude du Foie","award":["2007"],"award-info":[{"award-number":["2007"]}]},{"name":"Frenche Ministry of Health","award":["PHRC AOM 98038 and AOM 03009"],"award-info":[{"award-number":["PHRC AOM 98038 and AOM 03009"]}]},{"name":"Ligue Nationale Fran\u00c3\u00a7aise contre le Cancer","award":["2002"],"award-info":[{"award-number":["2002"]}]},{"name":"Soci\u00c3\u00a9t\u00c3\u00a9 nationale Fran\u00c3\u00a7aise de Gastroent\u00c3\u00a9rologie","award":["2000"],"award-info":[{"award-number":["2000"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    In cirrhosis, portal vein thrombosis (PVT) could be a cause or a consequence of the progression of liver disease. We analyzed data from a prospective trial of ultrasound screening for hepatocellular carcinoma in order to identify risk factors for and the impact of PVT in patients with cirrhosis. In all, 1,243 adults with cirrhosis without PVT were enrolled from 43 liver units in France and Belgium between June 2000 and March 2006. The mean follow\u2010up was 47 months. Doppler ultrasonography was used to check the portal vein. Progression of liver disease was defined by the development of: ascites, hepatic encephalopathy, variceal bleeding, prothrombin &lt;45%, serum bilirubin &gt;45 \u03bcmol\/L, albumin &lt;28 g\/L, and\/or creatinine &gt;115 \u03bcmol\/L. G20210A prothrombin and factor V gene mutations were assessed in sera stored at three large centers. The 5\u2010year cumulative incidence of PVT was 10.7%. PVT was mostly partial and varied over time. The development of PVT was independently associated with baseline esophageal varices (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.01) and prothrombin time (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.002), but not with disease progression before PVT, or prothrombotic mutations. Disease progression was independently associated with baseline age (hazard ratio [HR] 1.55; 95% confidence interval [CI]: 1.11\u20102.17), body mass index (HR 1.40; 95% CI: 1.01\u20101.95), prothrombin time (HR 0.79; 95% CI: 0.70\u20100.90), serum albumin (HR 0.97; 95% CI: 0.94\u20100.99), and esophageal varices (HR 1.70; 95% CI: 1.21\u20102.38) but not with the prior development of PVT (HR 1.32; 95% CI: 0.68\u20102.65).\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : In patients with cirrhosis, the development of PVT is associated with the severity of liver disease at baseline, but does not follow a recent progression of liver disease. There is no evidence that the development of PVT is responsible for further progression of liver disease. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;61:660\u2010667)\n                  <\/jats:p>","DOI":"10.1002\/hep.27546","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T02:37:30Z","timestamp":1412563050000},"page":"660-667","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":422,"title":["Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study"],"prefix":"10.1097","volume":"61","author":[{"given":"Filipe","family":"Nery","sequence":"first","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon,Service d'H\u00e9patologie,Clichy,France"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar \u2013 Universidade do Porto,Porto,Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chevret","sequence":"additional","affiliation":[{"name":"AP\u2010HP,H\u00f4pital Saint\u2010Louis, SBIM,Paris,France"},{"name":"Inserm,Universit\u00e9 Paris Diderot,UMR 717,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Condat","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint\u2010Camille,Service d'H\u00e9patogastro\u2010ent\u00e9rologie,Bry\u2010sur\u2010Marne,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"de Raucourt","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon,Service d'H\u00e9matologie Biologique,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larbi","family":"Boudaoud","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon,Service d'H\u00e9matologie Biologique,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon,Service d'H\u00e9patologie,Clichy,France"},{"name":"Inserm,Universit\u00e9 Paris Diderot,UMR 773\u2010CRB3,Paris,France"},{"name":"Inserm, U 970,Paris Cardiovascular Research Center, and Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"Plessier","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon,Service d'H\u00e9patologie,Clichy,France"},{"name":"Inserm,Universit\u00e9 Paris Diderot,UMR 773\u2010CRB3,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Roulot","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Avicenne,Unit\u00e9 d'H\u00e9patologie,Bobigny,France"},{"name":"Universit\u00e9 Paris 13 Paris\u2010Nord, UFR SMBH,Bobigny,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cendrine","family":"Chaffaut","sequence":"additional","affiliation":[{"name":"AP\u2010HP,H\u00f4pital Saint\u2010Louis, SBIM,Paris,France"},{"name":"Inserm,Universit\u00e9 Paris Diderot,UMR 717,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Bourcier","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Jean Verdier,Service d'H\u00e9pato\u2010gastroent\u00e9rologie,Bondy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Trinchet","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Jean Verdier,Service d'H\u00e9pato\u2010gastroent\u00e9rologie,Bondy,France"},{"name":"Inserm,UMR 1162,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique\u2010Charles","family":"Valla","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon,Service d'H\u00e9patologie,Clichy,France"},{"name":"Inserm,Universit\u00e9 Paris Diderot,UMR 773\u2010CRB3,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of Groupe d'Etude et de Traitement du Carcinome H\u00e9patocellulaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"hep27546-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2036.2009.04182.x","article-title":"Systematic review: portal vein thrombosis in cirrhosis","volume":"31","year":"2010","journal-title":"Aliment Pharmacol 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