{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:59:22Z","timestamp":1790470762587,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":176,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL107794"],"award-info":[{"award-number":["HL107794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["GRNT20460189"],"award-info":[{"award-number":["GRNT20460189"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>The cell death\u2010inducing DNA fragmentation factor alpha\u2010like effector c (CIDEC; also known in rodents as FSP27 or fat\u2010specific protein 27) is a lipid droplet\u2010associated protein that promotes intracellular triglyceride (TAG) storage. <jats:italic toggle=\"yes\">CIDEC\/Fsp27<\/jats:italic> is highly expressed in adipose tissue, but undetectable in normal liver. However, its hepatic expression rises during fasting or under genetic or diet\u2010induced hepatosteatosis in both mice and patients. Herein, we demonstrate that <jats:italic toggle=\"yes\">CIDEC\/Fsp27<\/jats:italic> is a direct transcriptional target of the nuclear receptor PPAR\u03b1 (peroxisome proliferator\u2010activated receptor alpha) in both mouse and human hepatocytes, and that preventing <jats:italic toggle=\"yes\">Fsp27<\/jats:italic> induction accelerates PPAR\u03b1\u2010stimulated fatty acid oxidation. We show that adenoviral\u2010mediated silencing of hepatic <jats:italic toggle=\"yes\">Fsp27<\/jats:italic> abolishes fasting\u2010induced liver steatosis in the absence of changes in plasma lipids. Finally, we report that anti\u2010<jats:italic toggle=\"yes\">Fsp27<\/jats:italic> short hairpin RNA and PPAR\u03b1 agonists synergize to ameliorate hepatosteatosis in mice fed a high fat diet. <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>: Together, our data highlight the physiological importance of <jats:italic toggle=\"yes\">CIDEC\/Fsp27<\/jats:italic> in TAG homeostasis under both physiological and pathological liver steatosis. Our results also suggest that patients taking fibrates likely have elevated levels of hepatic CIDEC, which may limit the efficient mobilization and catabolism of hepatic TAGs. (H<jats:sc>epatology<\/jats:sc> 2015;61:1227\u20131238)<\/jats:p>","DOI":"10.1002\/hep.27607","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T17:58:20Z","timestamp":1416592700000},"page":"1227-1238","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":72,"title":["CIDEC\/FSP27 is regulated by peroxisome proliferator\u2010activated receptor alpha and plays a critical role in fasting\u2010 and diet\u2010induced hepatosteatosis"],"prefix":"10.1097","volume":"61","author":[{"given":"C\u00e9dric","family":"Langhi","sequence":"first","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry & Molecular Biology,Center for Cardiovascular Research, Saint Louis University,Saint Louis,MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Bald\u00e1n","sequence":"additional","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry & Molecular Biology,Center for Cardiovascular Research, Saint Louis University,Saint Louis,MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"hep27607-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000282081","article-title":"The natural history of non\u2010alcoholic fatty liver disease","volume":"28","year":"2010","journal-title":"Dig Dis"},{"key":"hep27607-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40265-012-0004-0","article-title":"Nonalcoholic fatty liver disease: current issues and novel treatment approaches","volume":"73","year":"2013","journal-title":"Drugs"},{"key":"hep27607-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/ATVBAHA.111.241489","article-title":"CIDE proteins and lipid metabolism","volume":"32","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep27607-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1074\/jbc.M210062200","article-title":"Adipocyte\u2010specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator\u2010activated receptor gamma1 (PPARgamma1) overexpression","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"hep27607-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1016\/S0021-9258(19)50555-5","article-title":"Cloning and transcriptional regulation of a novel adipocyte\u2010specific gene, FSP27. 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