{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:26:48Z","timestamp":1791293208197,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":175,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"ANR national Agency for research","award":["08-MIE-013"],"award-info":[{"award-number":["08-MIE-013"]}]},{"name":"ESPACA-ARCUS","award":["2010-2014"],"award-info":[{"award-number":["2010-2014"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Interleukin (IL)\u201022 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL\u201022 may also cause inflammation and abnormal cell proliferation. The binding of IL\u201022 to its receptor is competed by IL\u201022 binding protein (IL\u201022BP), which may limit the deleterious effects of IL\u201022. The role of IL\u201022 and IL\u201022BP in chronic liver diseases is unknown. We addressed this question in individuals chronically infected with schistosomes or hepatitis C virus (HCV). We first demonstrate that schistosome eggs stimulate production of IL\u201022 transcripts and inhibit accumulation of IL22\u2010BP transcripts in schistosome\u2010infected mice, and that schistosome eggs selectively stimulate production of IL\u201022 in cultures of blood leukocytes from individuals chronically infected with <jats:italic toggle=\"yes\">Schistosoma japonicum<\/jats:italic>. High IL\u201022 levels in cultures correlated with protection against hepatic fibrosis and portal hypertension. To test further the implication of IL\u201022\/IL\u201022BP in hepatic disease, we analyzed common genetic variants of IL22RA2, which encodes IL\u201022BP, and found that the genotypes, AA, GG of rs6570136 (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.003; odds ratio [OR]\u2009=\u20092), and CC, TT of rs2064501 (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.01; OR\u2009=\u20092), were associated with severe fibrosis in Chinese infected with <jats:italic toggle=\"yes\">S. japonicum<\/jats:italic>. We confirmed this result in Sudanese (rs6570136 GG [<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.0007; OR\u2009=\u20098.2], rs2064501 TT [<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.02; OR\u2009=\u20093.1]), and Brazilians (rs6570136 GG [<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.003; OR\u2009=\u200926], rs2064501 TC, TT (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.03; OR\u2009=\u200911]) infected with <jats:italic toggle=\"yes\">S. mansoni<\/jats:italic>. The aggravating genotypes were associated with high IL22RA2 transcripts levels. Furthermore, these same variants were also associated with HCV\u2010induced fibrosis and cirrhosis (rs6570136 GG, GA [<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.007; OR\u2009=\u20091.7], rs2064501 TT, TC (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.004; OR\u2009=\u20092.4]). <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>: These results provide strong evidence that IL\u201022 protects against and IL\u201022BP aggravates liver fibrosis and cirrhosis in humans with chronic liver infections. Thus, pharmacological modulation of IL\u201022 BP may be an effective strategy to limit cirrhosis. (H<jats:sc>epatology<\/jats:sc> 2015;61:1321\u20131331)<\/jats:p>","DOI":"10.1002\/hep.27629","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T23:41:11Z","timestamp":1418082071000},"page":"1321-1331","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":75,"title":["IL\u201022 and IL\u201022 binding protein (IL\u201022BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections"],"prefix":"10.1097","volume":"61","author":[{"given":"Mathieu","family":"Sertorio","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunya","family":"Hou","sequence":"additional","affiliation":[{"name":"Hunan Institute of Parasitic Diseases,Hua\u2010Ban Qiao Road Yueyang,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo F.","family":"Carmo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,Petrolina,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lia","family":"Dessein","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Cabantous","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abdelwahed","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine,Wad Medani,Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Romano","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute,Salvador,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luydson","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Instituto do Figado,Pernambuco,Recife"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theomira","family":"Carmo","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute,Salvador,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Institute of Parasitic Diseases,Hua\u2010Ban Qiao Road Yueyang,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Varoquaux","sequence":"additional","affiliation":[{"name":"APHM, CHU Timone, Radiology,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"},{"name":"Gon\u00e7alo Moniz Institute,Salvador,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Hamdoun","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine,Wad Medani,Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"He","sequence":"additional","affiliation":[{"name":"Hunan Institute of Parasitic Diseases,Hua\u2010Ban Qiao Road Yueyang,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Adbelmaboud","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine,Wad Medani,Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Mergani","sequence":"additional","affiliation":[{"name":"College of Applied Medical Sciences,Taif University,Turabah,Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hunan Institute of Parasitic Diseases,Hua\u2010Ban Qiao Road Yueyang,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Monis","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine,Wad Medani,Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila Beltrao","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto do Figado,Pernambuco,Recife"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Halfon","sequence":"additional","affiliation":[{"name":"Virology department,H\u00f4pital europ\u00e9en,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bourli\u00e8re","sequence":"additional","affiliation":[{"name":"Hepatology Department,H\u00f4pital Saint\u2010Joseph,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo","family":"Parana","sequence":"additional","affiliation":[{"name":"Faculty of Medicine,Department of Medicine,Federal University of Bahia,Salvador,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitermayer","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute,Salvador,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gonnelli","sequence":"additional","affiliation":[{"name":"APHM,La Conception,Chirurgie plastique et reconstructrice,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Moura","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biologicas, Universidade Pernambuco,Recife,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasr Eldin","family":"Elwali","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine,Wad Medani,Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Argiro","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesheng","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Institute of Parasitic Diseases,Hua\u2010Ban Qiao Road Yueyang,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Dessein","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, UMR_S 906,Marseille,France"},{"name":"Inserm,U906,Marseille,France"},{"name":"APHM,CHU Timone,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"hep27629-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nri3349","article-title":"Innate lymphoid cells\u2014how did we miss them?","volume":"13","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"hep27629-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)\u201022 and IL\u201017 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","year":"2006","journal-title":"J Exp Med"},{"key":"hep27629-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrd4176","article-title":"Therapeutic opportunities of the IL\u201022\u2010IL\u201022R1 system","volume":"13","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"hep27629-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL\u201022 increases the innate immunity of tissues","volume":"21","year":"2004","journal-title":"Immunity"},{"key":"hep27629-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imr.12027","article-title":"IL\u201022, not simply a Th17 cytokine","volume":"252","year":"2013","journal-title":"Immunol Rev"},{"key":"hep27629-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","article-title":"IL\u201022 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis","volume":"36","year":"2006","journal-title":"Eur J Immunol"},{"key":"hep27629-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","article-title":"IL\u201022 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes","volume":"174","year":"2005","journal-title":"J Immunol"},{"key":"hep27629-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-009-0457-0","article-title":"IL\u201022 and IL\u201020 are key mediators of the epidermal alterations in psoriasis while IL\u201017 and IFN\u2010gamma are not","volume":"87","year":"2009","journal-title":"J Mol Med (Berl)"},{"key":"hep27629-bib-0009-20241017","first-page":"597","article-title":"IL\u201022 is required for Th17 cell\u2010mediated pathology in a mouse model of psoriasis\u2010like skin inflammation","volume":"118","year":"2008","journal-title":"J Clin Invest"},{"key":"hep27629-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin\u201022, a T(H)17 cytokine, mediates IL\u201023\u2010induced dermal inflammation and acanthosis","volume":"445","year":"2007","journal-title":"Nature"},{"key":"hep27629-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.4049\/jimmunol.178.4.2229","article-title":"The effects of IL\u201020 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis","volume":"178","year":"2007","journal-title":"J Immunol"},{"key":"hep27629-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL\u201022","volume":"12","year":"2011","journal-title":"Nat Immunol"},{"key":"hep27629-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00011-014-0727-3","article-title":"Role of Interleukin\u201022 in liver diseases","volume":"63","year":"2014","journal-title":"Inflamm Res"},{"key":"hep27629-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/hep.24486","article-title":"Interleukin\u201022 promotes human hepatocellular carcinoma by activation of STAT3","volume":"54","year":"2011","journal-title":"Hepatology"},{"key":"hep27629-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1084\/jem.20090900","article-title":"Interleukin (IL)\u201023 mediates Toxoplasma gondii\u2010induced immunopathology in the gut via matrixmetalloproteinase\u20102 and IL\u201022 but independent of IL\u201017","volume":"206","year":"2009","journal-title":"J Exp Med"},{"key":"hep27629-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/art.24220","article-title":"Proinflammatory role of the Th17 cytokine interleukin\u201022 in collagen\u2010induced arthritis in C57BL\/6 mice","volume":"60","year":"2009","journal-title":"Arthritis Rheum"},{"key":"hep27629-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.26916","article-title":"Pathological functions of interleukin\u201022 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment","volume":"59","year":"2014","journal-title":"Hepatology"},{"key":"hep27629-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.4049\/jimmunol.166.12.7090","article-title":"Cloning and characterization of IL\u201022 binding protein, a natural antagonist of IL\u201010\u2010related T cell\u2010derived inducible factor\/IL\u201022","volume":"166","year":"2001","journal-title":"J Immunol"},{"key":"hep27629-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1073\/pnas.171303198","article-title":"A soluble class II cytokine receptor, IL\u201022RA2, is a naturally occurring IL\u201022 antagonist","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep27629-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL\u201022) plays a protective role in T cell\u2010mediated murine hepatitis: IL\u201022 is a survival factor for hepatocytes via STAT3 activation","volume":"39","year":"2004","journal-title":"Hepatology"},{"key":"hep27629-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"G74","DOI":"10.1152\/ajpgi.00075.2009","article-title":"IL\u201022 is involved in liver regeneration after hepatectomy","volume":"298","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep27629-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.4049\/jimmunol.0903416","article-title":"Redundant and pathogenic roles for IL\u201022 in mycobacterial, protozoan, and helminth infections","volume":"184","year":"2010","journal-title":"J Immunol"},{"key":"hep27629-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1084\/jem.20090383","article-title":"Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes","volume":"206","year":"2009","journal-title":"J Exp Med"},{"key":"hep27629-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1086\/588826","article-title":"Regulatory role of interleukin\u201010 and interferon\u2010gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum","volume":"198","year":"2008","journal-title":"J Infect Dis"},{"issue":"Suppl","key":"hep27629-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S0074-02762001000900023","article-title":"Report of the second satellite symposium on ultrasound in schistosomiasis","volume":"96","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"hep27629-bib-0026-20241017","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","year":"2009","journal-title":"J Clin Invest"},{"key":"hep27629-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jaci.2009.03.041","article-title":"IL\u201022\u2010producing \u201cT22\u201d T cells account for upregulated IL\u201022 in atopic dermatitis despite reduced IL\u201017\u2010producing TH17 T cells","volume":"123","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"hep27629-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1086\/302526","article-title":"Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon\u2010gamma receptor gene","volume":"65","year":"1999","journal-title":"Am J Hum Genet"},{"key":"hep27629-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"G1019","DOI":"10.1152\/ajpgi.00239.2006","article-title":"IL\u201022\u2010mediated liver cell regeneration is abrogated by SOCS\u20101\/3 overexpression in vitro","volume":"292","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep27629-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1158\/1078-0432.CCR-07-4401","article-title":"Antiapoptotic activity of autocrine interleukin\u201022 and therapeutic effects of interleukin\u201022\u2010small interfering RNA on human lung cancer xenografts","volume":"14","year":"2008","journal-title":"Clin Cancer Res"},{"key":"hep27629-bib-0031-20241017","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/hep.24339","article-title":"In vivo consequences of liver\u2010specific interleukin\u201022 expression in mice: implications for human liver disease progression","volume":"54","year":"2011","journal-title":"Hepatology"},{"key":"hep27629-bib-0032-20241017","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin\u201022 treatment ameliorates alcoholic liver injury in a murine model of chronic\u2010binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep27629-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/j.gastro.2012.03.044","article-title":"Interleukin\u201022 promotes proliferation of liver stem\/progenitor cells in mice and patients with chronic hepatitis B virus infection","volume":"143","year":"2012","journal-title":"Gastroenterology"},{"key":"hep27629-bib-0034-20241017","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin\u201022 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","year":"2012","journal-title":"Hepatology"},{"key":"hep27629-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin\u201022 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","year":"2008","journal-title":"Nat Med"},{"key":"hep27629-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin\u201022 protects mice from inflammatory bowel disease","volume":"29","year":"2008","journal-title":"Immunity"},{"key":"hep27629-bib-0037-20241017","first-page":"534","article-title":"IL\u201022 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118","year":"2008","journal-title":"J Clin Invest"},{"key":"hep27629-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL\u201022BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","year":"2012","journal-title":"Nature"},{"key":"hep27629-bib-0039-20241017","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.4049\/jimmunol.178.9.5973","article-title":"IL\u201022 induces lipopolysaccharide\u2010binding protein in hepatocytes: a potential systemic role of IL\u201022 in Crohn's disease","volume":"178","year":"2007","journal-title":"J Immunol"},{"key":"hep27629-bib-0040-20241017","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin\u201022 but not interleukin\u201017 provides protection to hepatocytes during acute liver inflammation","volume":"27","year":"2007","journal-title":"Immunity"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.27629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201504000-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:15:51Z","timestamp":1729210551000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201504000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.27629","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,10]]},"assertion":[{"value":"2014-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}