{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:13:25Z","timestamp":1791504805044,"version":"4.3.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":200,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    Hepatorenal syndrome (HRS), a serious complication of cirrhosis, is associated with high mortality without treatment. Terlipressin with albumin is effective in the reversal of HRS. Where terlipressin is not available, as in the United States, midodrine and octreotide with albumin are used as an alternative treatment of HRS. The aim was to compare the effectiveness of terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of HRS in a randomized controlled trial. Twenty\u2010seven patients were randomized to receive terlipressin with albumin (TERLI group) and 22 to receive midodrine and octreotide plus albumin (MID\/OCT group). The TERLI group received terlipressin by intravenous infusion, initially 3 mg\/24 hours, progressively increased to 12 mg\/24 hours if there was no response. The MID\/OCT group received midodrine orally at an initial dose of 7.5 mg thrice daily, with the dose increased to a maximum of 12.5 mg thrice daily, together with octreotide subcutaneously: initial dose 100 \u03bcg thrice daily and up to 200 \u03bcg thrice daily. Both groups received albumin intravenously 1 g\/kg of body weight on day 1 and 20\u201040 g\/day thereafter. There was a significantly higher rate of recovery of renal function in the TERLI group (19\/27, 70.4%) compared to the MID\/OCT group (6\/21, 28.6%), P\u2009=\u20090.01. Improvement in renal function and lower baseline Model for End\u2010Stage Liver Disease score were associated with better survival.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : Terlipressin plus albumin is significantly more effective than midodrine and octreotide plus albumin in improving renal function in patients with HRS (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;62:567\u2013574\n                  <\/jats:p>","DOI":"10.1002\/hep.27709","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T17:17:49Z","timestamp":1421428669000},"page":"567-574","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":329,"title":["Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial"],"prefix":"10.1097","volume":"62","author":[{"given":"Marta","family":"Cavallin","sequence":"first","affiliation":[{"name":"Department of Medicine,DIMED,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic, College of Medicine,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Merli","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine,\u201cSapienza\u201d University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Fasolato","sequence":"additional","affiliation":[{"name":"Department of Medicine,DIMED,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Toniutto","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Udine,Udine,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Salerno","sequence":"additional","affiliation":[{"name":"IRCCS Hospital, University of Milan,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine,University of Bologna,Bologna,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Giulio","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Florence,Florence,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Colletta","sequence":"additional","affiliation":[{"name":"General Hospital of Omegna (Verbania),Verbania,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Salinas","sequence":"additional","affiliation":[{"name":"Hospital Giovanni XXIII of Monastier di Treviso,Treviso,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"General Hospital of Comiso (Ragusa),Ragusa,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ridola","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine,\u201cSapienza\u201d University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Fornasiere","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Udine,Udine,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Caraceni","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine,University of Bologna,Bologna,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Morando","sequence":"additional","affiliation":[{"name":"Department of Medicine,DIMED,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Piano","sequence":"additional","affiliation":[{"name":"Department of Medicine,DIMED,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Gatta","sequence":"additional","affiliation":[{"name":"Department of Medicine,DIMED,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Angeli","sequence":"additional","affiliation":[{"name":"Department of Medicine,DIMED,Padua,Italy"},{"name":"Unit of Hepatic Emergencies and Liver Transplantation, University of Padua,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Italian Association for the Study of the Liver Study Group on Hepatorenal 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