{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:07:35Z","timestamp":1792087655564,"version":"4.4.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":165,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    Current guidelines recommend surgical resection as the primary treatment for a single hepatocellular cancer (HCC) with Child's A cirrhosis, normal serum bilirubin, and no clinically significant portal hypertension. We determined how frequently guidelines were followed and whether straying from them impacted survival. BRIDGE is a multiregional cohort study including HCC patients diagnosed between January 1, 2005 and June 30, 2011. A total of 8,656 patients from 20 sites were classified into four groups: (A) 718 ideal resection candidates who were resected; (B) 144 ideal resection candidates who were not resected; (C) 1,624 nonideal resection candidates who were resected; and (D) 6,170 nonideal resection candidates who were not resected. Median follow\u2010up was 27 months. Log\u2010rank and Cox's regression analyses were conducted to determine differences between groups and variables associated with survival. Multivariate analysis of all ideal candidates for resection (A+B) revealed a higher risk of mortality with treatments other than resection. For all resected patients (A+C), portal hypertension and bilirubin &gt;1 mg\/dL were not associated with mortality. For all patients who were not ideal candidates for resection (C+D), resection was associated with better survival, compared to embolization and \u201cother\u201d treatments, but was inferior to ablation and transplantation.\n                    <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    : The majority of patients undergoing resection would not be considered ideal candidates based on current guidelines. Not resecting ideal candidates was associated with higher mortality. The study suggests that selection criteria for resection may be modestly expanded without compromising outcomes, and that some nonideal candidates may still potentially benefit from resection over other treatment modalities. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;62:440\u2013451\n                  <\/jats:p>","DOI":"10.1002\/hep.27745","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T22:55:50Z","timestamp":1423781750000},"page":"440-451","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":368,"title":["The role of hepatic resection in the treatment of hepatocellular cancer"],"prefix":"10.1097","volume":"62","author":[{"given":"Sasan","family":"Roayaie","sequence":"first","affiliation":[{"name":"North Shore\u2010LIJ Health Systems,Lenox Hill Hospital,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghalib","family":"Jibara","sequence":"additional","affiliation":[{"name":"Brookdale's Medical Center, Department of Urology,Brooklyn,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parissa","family":"Tabrizian","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Liver Cancer,National Cancer Center,Goyang,Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology,Changhai Hospital, Second Military Medical University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery,West China Hospital, Sichuan University,Chengdu,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Digestive Interventional Radiology,Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University,Xi'an,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Izzo","sequence":"additional","affiliation":[{"name":"Hepatobiliary Unit,National Cancer Institute of Naples, G. Pascale Foundation,Naples,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mishan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery,Sun Yat\u2010sen University Cancer Center,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"additional","affiliation":[{"name":"Hepatology and Digestive Oncology Unit,H\u00f4pital Saint\u2010Andr\u00e9,Bordeaux,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Liverpool,Liverpool,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Kinki University School of Medicine,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis R.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic College of Medicine,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Sherman","sequence":"additional","affiliation":[{"name":"University of Toronto and University Health Network,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"key":"hep27745-bib-0001-20241017","first-page":"1208","article-title":"Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma","volume":"42","year":"2005","journal-title":"Hepatology"},{"key":"hep27745-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jhep.2011.12.001","article-title":"EASL\u2010EORTC clinical practice guidelines: management of hepatocellular carcinoma","volume":"56","year":"2012","journal-title":"J Hepatol"},{"key":"hep27745-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/hep.510300629","article-title":"Intention\u2010to\u2010treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation","volume":"30","year":"1999","journal-title":"Hepatology"},{"key":"hep27745-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2217\/fon.12.183","article-title":"Adherence to American Association for the Study of Liver Diseases guidelines for the management of hepatocellular carcinoma: results of an Italian field practice multicenter study","volume":"9","year":"2013","journal-title":"Future Oncol"},{"key":"hep27745-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2407-9-33","article-title":"Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multi\u2010center study","volume":"9","year":"2009","journal-title":"BMC Cancer"},{"key":"hep27745-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/SLA.0b013e31828329b8","article-title":"A snapshot of the effective indications and results of surgery for hepatocellular carcinoma in tertiary referral centers: is it adherent to the EASL\/AASLD recommendations?: an observational study of the HCC east\u2010west study group","volume":"257","year":"2013","journal-title":"Ann Surg"},{"key":"hep27745-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1053\/j.gastro.2008.02.091","article-title":"Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"hep27745-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/SLA.0b013e3181b977a5","article-title":"Is portal hypertension a contraindication to hepatic resection?","volume":"250","year":"2009","journal-title":"Ann Surg"},{"key":"hep27745-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1007\/s00268-005-0524-9","article-title":"Portal hypertension: contraindication to liver surgery?","volume":"30","year":"2006","journal-title":"World J Surg"},{"key":"hep27745-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00534-012-0540-8","article-title":"Assessment of safety in hepatic resection for hepatocellular carcinoma focusing on indirect hyperbilirubinemia","volume":"20","year":"2013","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"hep27745-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/liv.12199","article-title":"Influence of clinically significant portal hypertension on survival after hepatic resection for hepatocellular carcinoma in cirrhotic patients","volume":"33","year":"2013","journal-title":"Liver Int"},{"key":"hep27745-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1001\/archsurg.143.11.1082","article-title":"Hepatectomy for stage B and stage C hepatocellular carcinoma in the barcelona clinic liver cancer classification: results of a prospective analysis","volume":"143","year":"2008","journal-title":"Arch Surg"},{"key":"hep27745-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00268-010-0929-y","article-title":"Selection criteria for hepatectomy in patients with hepatocellular carcinoma classified as Child\u2010Pugh class B","volume":"35","year":"2011","journal-title":"World J Surg"},{"key":"hep27745-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00534-011-0379-4","article-title":"Tumor\u2010related factors do not influence the prognosis of solitary hepatocellular carcinoma after partial hepatectomy","volume":"18","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"hep27745-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jhep.2013.12.015","article-title":"Accurate computed tomography\u2010based portal pressure assessment in patients with hepatocellular carcinoma","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep27745-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/hep.27431","article-title":"Portal hypertension and the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis: a systematic review and meta\u2010analysis","volume":"61","year":"2015","journal-title":"Hepatology"},{"key":"hep27745-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/SLA.0b013e3181efc656","article-title":"A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the milan criteria","volume":"252","year":"2010","journal-title":"Ann Surg"},{"key":"hep27745-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jhep.2012.05.007","article-title":"A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"hep27745-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/01.sla.0000201480.65519.b8","article-title":"A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma","volume":"243","year":"2006","journal-title":"Ann Surg"},{"key":"hep27745-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jhep.2012.11.009","article-title":"Comparison of resection and ablation for hepatocellular carcinoma: a cohort study based on a Japanese nationwide survey","volume":"58","year":"2013","journal-title":"J Hepatol"},{"key":"hep27745-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3748\/wjg.v19.i3.366","article-title":"Role of surgical resection for multiple hepatocellular carcinomas","volume":"19","year":"2013","journal-title":"World J Gastroenterol"},{"key":"hep27745-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"e68193","DOI":"10.1371\/journal.pone.0068193","article-title":"Comparison of long\u2010term survival of patients with BCLC stage B hepatocellular carcinoma after liver resection or transarterial chemoembolization","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"hep27745-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1002\/cncr.26561","article-title":"Hepatic resection versus transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma with portal vein tumor thrombus","volume":"118","year":"2012","journal-title":"Cancer"},{"key":"hep27745-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jhep.2014.03.012","article-title":"Partial hepatectomy vs. transcatheter arterial chemoembolization for resectable multiple hepatocellular carcinoma beyond Milan Criteria: a RCT","volume":"61","year":"2014","journal-title":"J Hepatol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.27745","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201508000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T20:48:15Z","timestamp":1729198095000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201508000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,20]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.27745","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,20]]},"assertion":[{"value":"2014-02-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}