{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:39:36Z","timestamp":1793738376744,"version":"4.6.1"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":165,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>\n                    Sinusoidal dilatation found in the absence of an impaired sinusoidal blood outflow has been so far of unclear significance. Sinusoidal dilatation may actually be a nonspecific feature of impaired portal venous blood inflow, whatever the cause, or a feature of severe systemic inflammatory reaction syndrome, whatever the cause. Sinusoidal dilatation is mainly located in the centrilobular area even in the absence of an outflow block. A predominantly periportal location is specifically found in oral contraceptive users, associated with an inflammatory condition. There is strong evidence for the association of sinusoidal dilatation and oxaliplatin\u2010based chemotherapy but not for estroprogestative steroids or thiopurine derivatives. Exposure to anabolic androgen steroids appears to cause sinusoidal changes different from a mere sinusoidal dilatation.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : There is evidence of activation of the interleukin\u20106 and vascular endothelial growth factor pathways in sinusoidal dilatation, but the mechanisms linking the activation of these pathways with the microvascular changes must be identified. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;62:956\u2013963)\n                  <\/jats:p>","DOI":"10.1002\/hep.27747","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T07:33:02Z","timestamp":1423812782000},"page":"956-963","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":63,"title":["The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome"],"prefix":"10.1097","volume":"62","author":[{"given":"Chiara","family":"Marzano","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Clinica, UOC di Gastroenterologia, Umberto I Policlinico di Roma,Sapienza Universit\u00e0 di Roma,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Cazals\u2010Hatem","sequence":"additional","affiliation":[{"name":"DHU UNITY, Laboratoire Central d'Anatomie et de Cytologie Pathologiques,H\u00f4pital Beaujon, HUPNVS, APHP,Clichy\u2010la\u2010Garenne,France"},{"name":"DHU Unity, P\u00f4le des Maladies de l'Appareil Digestif, Service d'H\u00e9patologie, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie,H\u00f4pital Beaujon, AP\u2010HP,Clichy,France"},{"name":"CRI Paris\u2010Montmartre, UMR 1149,Universit\u00e9 Paris Diderot,PRES SPC, H\u00f4pital Bichat,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"DHU Unity, P\u00f4le des Maladies de l'Appareil Digestif, Service d'H\u00e9patologie, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie,H\u00f4pital Beaujon, AP\u2010HP,Clichy,France"},{"name":"Inserm, U970, Paris Cardiovascular Research Center\u2010PARCC,Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9, UMR\u2010S970,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique\u2010Charles","family":"Valla","sequence":"additional","affiliation":[{"name":"DHU Unity, P\u00f4le des Maladies de l'Appareil Digestif, Service d'H\u00e9patologie, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie,H\u00f4pital Beaujon, AP\u2010HP,Clichy,France"},{"name":"CRI Paris\u2010Montmartre, UMR 1149,Universit\u00e9 Paris Diderot,PRES SPC, H\u00f4pital Bichat,Paris,France"},{"name":"Inserm U1149,H\u00f4pital Bichat,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"key":"hep27747-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gut.2003.037135","article-title":"Association of idiopathic hepatic sinusoidal dilatation with the immunological features of the antiphospholipid syndrome","volume":"53","year":"2004","journal-title":"Gut"},{"key":"hep27747-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"901","DOI":"10.5858\/2004-128-901-SDACIL","article-title":"Sinusoidal dilatation and congestion in liver biopsy: is it always due to venous outflow impairment?","volume":"128","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"hep27747-bib-0003-20241017","first-page":"103","article-title":"The significance of centrilobular sinusoidal changes in liver biopsies","volume":"7","year":"1970","journal-title":"Scand J Gastroenterol Suppl"},{"key":"hep27747-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0016-5085(78)90853-3","article-title":"Incidence and clinical significance of sinusoidal dilatation in liver biopsies","volume":"75","year":"1978","journal-title":"Gastroenterology"},{"key":"hep27747-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/hep.1840050427","article-title":"The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse","volume":"5","year":"1985","journal-title":"Hepatology"},{"key":"hep27747-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/hep.22772","article-title":"Vascular disorders of the liver","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"hep27747-bib-0007-20241017","first-page":"349","article-title":"Ultrastructural lesions of the liver in human peliosis. 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