{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:28:11Z","timestamp":1790483291525,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":160,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    Sustained viral response (SVR) is the optimal outcome of hepatitis C virus (HCV) therapy, yet more detailed data are required to confirm its clinical value. Individuals receiving treatment in 1996\u20102011 were identified using the Scottish HCV clinical database. We sourced data on 10 clinical events: liver, nonliver, and all\u2010cause mortality; first hospitalisation for severe liver morbidity (SLM); cardiovascular disease (CVD); respiratory disorders; neoplasms; alcohol\u2010intoxication; drug intoxication; and violence\u2010related injury (note: the latter three events were selected\n                    <jats:italic toggle=\"yes\">a priori<\/jats:italic>\n                    to gauge ongoing chaotic lifestyle behaviours). We determined the association between SVR attainment and each outcome event, in terms of the relative hazard reduction and absolute risk reduction (ARR). We tested for an interaction between SVR and liver disease severity (mild vs. nonmild), defining mild disease as an aspartate aminotransferase\u2010to\u2010platelet ratio index (APRI) &lt;0.7. Our cohort comprised 3,385 patients (mean age: 41.6 years), followed\u2010up for a median 5.3 years (interquartile range: 3.3\u20108.2). SVR was associated with a reduced risk of liver mortality (adjusted hazard ratio [AHR]: 0.24;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001), nonliver mortality (AHR, 0.68;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.026), all\u2010cause mortality (AHR, 0.49;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001), SLM (AHR, 0.21;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001), CVD (AHR, 0.70;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.001), alcohol intoxication (AHR, 0.52;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.003), and violence\u2010related injury (AHR, 0.51;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.002). After 7.5 years, SVR was associated with significant ARRs for liver mortality, all\u2010cause mortality, SLM, and CVD (each 3.0%\u20104.7%). However, we detected a strong interaction, in that ARRs were considerably higher for individuals with nonmild disease than for individuals with mild disease.\n                    <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    : The conclusions are 3\u2010fold: (1) Overall, SVR is associated with reduced hazard for a range of hepatic and nonhepatic events; (2) an association between SVR and behavioral events is consistent with SVR patients leading healthier lives; and (3) the short\u2010term value of SVR is greatest for those with nonmild disease. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;62:355\u2013364\n                  <\/jats:p>","DOI":"10.1002\/hep.27766","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T02:29:31Z","timestamp":1424917771000},"page":"355-364","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":98,"title":["Toward a more complete understanding of the association between a hepatitis C sustained viral response and cause\u2010specific outcomes"],"prefix":"10.1097","volume":"62","author":[{"given":"Hamish A.","family":"Innes","sequence":"first","affiliation":[{"name":"School of Health and Life Sciences,Glasgow Caledonian University,Glasgow,United Kingdom"},{"name":"Health Protection Scotland,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"McDonald","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences,Glasgow Caledonian University,Glasgow,United Kingdom"},{"name":"Health Protection Scotland,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Dillon","sequence":"additional","affiliation":[{"name":"Ninewells Hospital and Medical School,Dundee,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Allen","sequence":"additional","affiliation":[{"name":"University Hospital,Crosshouse,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Royal Infirmary Edinburgh,Edinburgh,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldberg","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences,Glasgow Caledonian University,Glasgow,United Kingdom"},{"name":"Health Protection Scotland,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Mills","sequence":"additional","affiliation":[{"name":"Gartnavel General Hospital,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Barclay","sequence":"additional","affiliation":[{"name":"Glasgow Royal Infirmary,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wilks","sequence":"additional","affiliation":[{"name":"Western General Hospital,Edinburgh,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Valerio","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences,Glasgow Caledonian University,Glasgow,United Kingdom"},{"name":"Health Protection Scotland,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Fox","sequence":"additional","affiliation":[{"name":"The Brownlee Center,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diptendu","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Kirkcaldy Hospital,Fife,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Monklands Hospital,Lanarkshire,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Morris","sequence":"additional","affiliation":[{"name":"Southern General Hospital,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fraser","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary,Aberdeen,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Glasgow Royal Infirmary,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bramley","sequence":"additional","affiliation":[{"name":"Stirling Royal Infirmary,Stirling,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences,Glasgow Caledonian University,Glasgow,United Kingdom"},{"name":"Health Protection Scotland,Glasgow,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"issue":"5 Suppl 1","key":"hep27766-bib-0001-20241017","first-page":"S35","article-title":"Natural history of chronic hepatitis 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