{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:19:53Z","timestamp":1791559193659,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":127,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Recent studies have shown that liver cirrhosis (LC) behaves as an acquired hypercoagulable state with increased thrombotic risk. This is why anticoagulation therapy (AT) is now frequently used in these patients. Variceal bleeding is a severe complication of LC. It is unknown whether AT may impact the outcome of bleeding in these patients. Fifty\u2010two patients on AT with upper gastrointestinal bleeding (UGIB) were evaluated. Portal vein thrombosis (PVT) and different cardiovascular disorders (CVDs) were the indication for AT in 14 and 38 patients, respectively. Overall, 104 patients with LC and UGIB not under AT matched for severity of LC, age, sex, source of bleeding, and Sequential Organ Failure Assessment (SOFA) score served as controls. UGIB was attributed to portal hypertension (PH) in 99 (63%) patients and peptic\/vascular lesions in 57 (37%). Twenty\u2010six (17%) patients experienced 5\u2010day failure; SOFA, source of UGIB, and PVT, but not AT, were independent predictors of 5\u2010day failure. In addition, independent predictors of 6\u2010week mortality, which was observed in 26 (11%) patients, were SOFA, Charlson Comorbidity index, and use of AT for a CVD. There were no differences between patients with\/without AT in needs for rescue therapies, intensive care unit admission, transfusions, and hospital stay. <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>: Factors that impact the outcome of UGIB in patients under AT are degree of multiorgan failure and comorbidity, but not AT itself. (H<jats:sc>epatology<\/jats:sc> 2015;62:575\u2013583<\/jats:p>","DOI":"10.1002\/hep.27783","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T04:56:14Z","timestamp":1426222574000},"page":"575-583","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":122,"title":["Impact of anticoagulation on upper\u2010gastrointestinal bleeding in cirrhosis. A retrospective multicenter study"],"prefix":"10.1097","volume":"62","author":[{"given":"Federica","family":"Cerini","sequence":"first","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory,Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS,University of Barcelona,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Mart\u00ednez","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital Universitario Ram\u00f3n y Cajal,IRYCIS,University of Alcal\u00e1,Madrid,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Torres","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Core Facility,IDIBAPS,Hospital Clinic Barcelona,Barcelona,Spain"},{"name":"Biostatistics Unit,Faculty of Medicine,Universitat Aut\u00f2noma de Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Puente","sequence":"additional","affiliation":[{"name":"Hepatology Unit,Gastroenterolgy Department,Marques de Valdecilla University Hospital, Marques de Valdecilla Investigation Institute (IDIVAL),Santander,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Casas","sequence":"additional","affiliation":[{"name":"Liver Unit,Department of Gastroenterology,Corporaci\u00f3n Sanitaria Parc Taul\u00ed. Sabadell,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Vinaixa","sequence":"additional","affiliation":[{"name":"Liver Transplantation and Hepatology Unit,Hospital Universitari i Polit\u00e8cnic La Fe de Valencia,Valencia,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Liver Transplantation and Hepatology Unit,Hospital Universitari i Polit\u00e8cnic La Fe de Valencia,Valencia,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Ardevol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital Sant Pau,Barcelona,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Augustin","sequence":"additional","affiliation":[{"name":"Liver Unit\u2010Department of Internal Medicine,Hospital Universitari Vall d'Hebron,Institut de Recerca (VHIR),Universitat Aut\u00f2noma de Barcelona,Barcelona,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Llop","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital Universitario Puerta de Hierro\u2010Majadahonda,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Senosia\u00edn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital General Universitario Gregorio Mara\u00f1\u00f3n, (IISGM),Facultad de Medicina,Universidad Complutense,Madrid,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e0ndid","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital Sant Pau,Barcelona,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Hepatology Unit,Gastroenterolgy Department,Marques de Valdecilla University Hospital, Marques de Valdecilla Investigation Institute (IDIVAL),Santander,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ba\u00f1ares","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital General Universitario Gregorio Mara\u00f1\u00f3n, (IISGM),Facultad de Medicina,Universidad Complutense,Madrid,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Genesc\u00e1","sequence":"additional","affiliation":[{"name":"Liver Unit\u2010Department of Internal Medicine,Hospital Universitari Vall d'Hebron,Institut de Recerca (VHIR),Universitat Aut\u00f2noma de Barcelona,Barcelona,Spain"},{"name":"Department of Gastroenterology,Hospital Universitario Puerta de Hierro\u2010Majadahonda,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Sope\u00f1a","sequence":"additional","affiliation":[{"name":"Liver Unit,Department of Gastroenterology,Corporaci\u00f3n Sanitaria Parc Taul\u00ed. Sabadell,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Albillos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Hospital Universitario Ram\u00f3n y Cajal,IRYCIS,University of Alcal\u00e1,Madrid,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Bosch","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory,Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS,University of Barcelona,Spain"},{"name":"CIBERehd (Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Hern\u00e1ndez\u2010Gea","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic 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