{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:58:03Z","timestamp":1787504283955,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009187","name":"Mason Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Health Service (NHS) Research Scotland"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    Acute kidney injury in the context of acetaminophen (APAP; paracetamol)\u2010induced liver injury is an important predictor of the requirement for urgent liver transplantation (LT) to avoid death. However, the prognostic biomarker used to report kidney dysfunction (serum creatinine concentration) has suboptimal sensitivity and specificity. Kidney injury molecule 1 (KIM\u20101) can be quantified in plasma as a sensitive and specific biomarker of kidney injury in both clinical and preclinical studies. Therefore, plasma KIM\u20101 has potential as a sensitive prognostic biomarker of patient outcome post\u2010APAP overdose. In a cohort of APAP overdose patients (N\u2009=\u200974) with and without established liver injury, we quantified plasma KIM\u20101 by immunoassay on the first day of admission to a LT unit and assessed its diagnostic performance to predict outcome compared with serum creatinine concentration. Day 1 plasma KIM\u20101 was significantly elevated in patients that died or required LT, compared to spontaneous survivors (1,182\u2009\u00b1\u2009251 vs. 214\u2009\u00b1\u200945 pg\/mL;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.005). Receiver operator characteristic analysis demonstrated the superiority of KIM\u20101 (area under the curve [AUC]: 0.87; 95% confidence interval [CI]: 0.78\u20100.95; 0.56 sensitivity at 0.95 specificity), compared with serum creatinine (AUC, 0.76; 95% CI: 0.64\u20100.87; 0.08 sensitivity at 0.95 specificity) and other current prognostic indicators, when measured on the first day of enrollment into the study. Furthermore, KIM\u20101 was found to be a statistically significant independent predictor of outcome at the 5% level (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.0386) in a multivariable logistic regression model that considered all measured factors (pseudo\u2010R^2\u2009=\u20090.895).\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : Early measurement of plasma KIM\u20101 represents a more sensitive predictor of patient outcome than serum creatinine concentration post\u2010APAP overdose. With further development, plasma KIM\u20101 could significantly improve prognostic stratification. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;62:591\u2013599\n                  <\/jats:p>","DOI":"10.1002\/hep.27857","type":"journal-article","created":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T01:53:11Z","timestamp":1429321991000},"page":"591-599","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen\u2010Induced Liver Injury"],"prefix":"10.1097","volume":"62","author":[{"given":"Daniel J.","family":"Antoine","sequence":"first","affiliation":[{"name":"MRC Center for Drug Safety Science, Department of Molecular & Clinical Pharmacology,Institute of Translational Medicine,University of Liverpool,Liverpool,United Kingdom"},{"name":"Renal Division, Department of Medicine,Brigham and Women's Hospital, Harvard Medical School,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata S.","family":"Sabbisetti","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine,Brigham and Women's Hospital, Harvard Medical School,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,Institute of Translational Medicine,University of Liverpool,Liverpool,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,Institute of Translational Medicine,University of Liverpool,Liverpool,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren G.N.","family":"Craig","sequence":"additional","affiliation":[{"name":"Scottish Liver Transplantation Unit,Royal Infirmary of Edinburgh,Edinburgh,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Scottish Liver Transplantation Unit,Royal Infirmary of Edinburgh,Edinburgh,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph V.","family":"Bonventre","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine,Brigham and Women's Hospital, Harvard Medical School,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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