{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:36:32Z","timestamp":1790429792442,"version":"4.1.0"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    Autoimmune hepatitis (AIH) is a chronic inflammatory disease characterized by a loss of tolerance toward the hepatocellular epithelium. Liver transplantation (LT) represents the ultimate therapeutic option for a fulminant course or end\u2010stage liver disease. The aim of this study was to elucidate the clinical, serological, and genetic features of remission, relapse, and overall and LT\u2010free survival. Between 2000 and 2014, 354 AIH patients from Hannover Medical School were included. Clinical, laboratory, and histological reports were analyzed. DRB1 allele analyses were performed in 264 AIH and 399 non\u2010AIH patients. Cox's regression analysis was performed to identify factors significantly associated with survival. Patients diagnosed in childhood were at higher risk for relapses (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.003), requirement for LTs (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.014, log rank), and had a reduced life expectancy (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.001, log rank). Detection of soluble liver antigen\/liver pancreas antigen (SLA\/LP) antibodies was significantly associated with reduced overall and LT\u2010free survival (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.037;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.021). Cirrhosis, which was evident in 25% at first diagnosis, was found to be a predictor of poor survival and requirement for LT (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.003;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.009). DRB1*04:01\u2010positive phenotype was associated with a higher rate of complete remissions and with a lower frequency of cirrhosis and LTs. There were no significant differences for subsequent relapses or survival in patients achieving either partial or complete remission.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : Diagnosis &lt;18 years, histological cirrhosis at first diagnosis and SLA\/LP antibodies are major risk factors for a poor short\u2010 and long\u2010term outcome. These patients are in need of high surveillance. Separating patients with positive SLA\/LP antibodies into a third group may be reconsidered. DRB1*04:01 positivity has been identified in association with a favorable clinical outcome. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2015;62:1524\u20131535)\n                  <\/jats:p>","DOI":"10.1002\/hep.27983","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T14:12:56Z","timestamp":1436883176000},"page":"1524-1535","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":136,"title":["Prediction of short\u2010 and long\u2010term outcome in patients with autoimmune hepatitis"],"prefix":"10.1097","volume":"62","author":[{"given":"Martha M.","family":"Kirstein","sequence":"first","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Metzler","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Geiger","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyk","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hallensleben","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Institute for Transfusion Medicine,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Vogel","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"hep27983-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/hep.1840190629","article-title":"Classification of chronic hepatitis: diagnosis, grading and staging","volume":"19","year":"1994","journal-title":"Hepatology"},{"key":"hep27983-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","year":"1995","journal-title":"J Hepatol"},{"key":"hep27983-bib-0003-20241017","first-page":"793","article-title":"Association 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