{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:37:09Z","timestamp":1782401829235,"version":"3.54.5"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Increasing evidence in recent years has suggested that B cells act as a crucial regulator in autoimmune diseases. However, little is known about their role in autoimmune hepatitis (AIH) and the underlying regulatory mechanisms. In this study, we show that B cells ameliorated experimental AIH (EAH) by suppressing CD4<jats:sup>+<\/jats:sup> T\u2010cell responses and that CD11b expression on B cells was required for the regulatory function of B cells. <jats:italic toggle=\"yes\">In vitro<\/jats:italic> studies reveal that the suppressive function of CD11b was mediated by the impairment of T\u2010cell antigen receptor (TCR) signaling transduction and the promotion of TCR down\u2010regulation. Moreover, we show that the increased CD11b expression on B cells was interleukin (IL)\u221210 dependent and that additional IL\u201010 stimulation promoted CD11b expression on B cells, thereby enhancing B\u2010cell regulatory effects. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: These findings reveal a previously unrecognized role for CD11b in B\u2010cell regulatory function and its protective effect on EAH. (H<jats:sc>epatology<\/jats:sc> 2015;62:1563\u20131575)<\/jats:p>","DOI":"10.1002\/hep.28001","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T09:15:54Z","timestamp":1437729354000},"page":"1563-1575","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":77,"title":["B cells expressing CD11b effectively inhibit CD4+ T\u2010cell responses and ameliorate experimental autoimmune hepatitis in mice"],"prefix":"10.1097","volume":"62","author":[{"given":"Xiaoming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE\/MOH, School of Basic Medical Sciences,Fudan University,Shanghai,China"},{"name":"Biotherapy Research Center, Fudan University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Immunology, 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