{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:01:09Z","timestamp":1792008069537,"version":"4.4.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Liver Cirrhosis Clinical Research Center"},{"name":"Korea Healthcare Technology R & D project, Ministry of Health and Welfare, Republic ofKorea","award":["A102065"],"award-info":[{"award-number":["A102065"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Several risk prediction models have been created to predict hepatitis B virus (HBV)\u2010related hepatocellular carcinoma (HCC) occurrence, with promising results. However, their prognostic performances need to be validated in the era of antiviral therapy. From 2006 to 2011, patients with chronic HBV infection were recruited and those with a history of HCC or hepatic decompensation were excluded. At enrollment, liver stiffness (LS) was measured using transient elastography. We assessed the performances of conventional HCC prediction models (CU\u2010HCC, GAG\u2010HCC, REACH\u2010B, and LSM\u2010HCC scores) and the modified REACH\u2010B (mREACH\u2010B) score where LS values were incorporated into REACH\u2010B score instead of serum HBV\u2010DNA levels. Of 1,308 subjects analyzed, the median age was 50.0 years (883 men). During the follow\u2010up (median, 75.3 months), HCC developed in 125 (9.6%) patients. mREACH\u2010B score had the highest areas under the receiver operating characteristic curves (AUROCs) for the prediction of HCC development at 3\/5 years (0.828\/0.806), compared with LSM\u2010HCC (0.777\/0.759), GAG\u2010HCC (0.751\/0.757), REACH\u2010B (0.717\/0.699), and CU\u2010HCC (0.698\/0.700) scores, respectively, with statistical significances (all <jats:italic toggle=\"yes\">P<\/jats:italic> values &lt;0.05 vs. mREACH\u2010B). When serum HBV\u2010DNA levels were excluded from the formula for REACH\u2010B score, AUROCs for HCC development at 3\/5 years improved paradoxically (from 0.717\/0.699 to 0.757\/0.732, respectively). In patients with antiviral therapy (n\u2009=\u2009848), mREACH\u2010B score had the better prognostic performances for HCC development at 3\/5 years, compared to other prediction models. However, in patients without antiviral therapy (n\u2009=\u2009460), it had the prognostic performances comparable to those of other prediction models. <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>: Prognostic performances of mREACH\u2010B score seemed better compared to conventional models. In the era of antiviral therapy, incorporation of serum HBV\u2010DNA level should be applied cautiously and individual risks should be assessed effectively based on the fibrotic burden.(H<jats:sc>epatology<\/jats:sc> 2015;62:1757\u20131766)<\/jats:p>","DOI":"10.1002\/hep.28115","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T23:58:49Z","timestamp":1438905529000},"page":"1757-1766","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":106,"title":["Validation of hepatitis B virus\u2013related hepatocellular carcinoma prediction models in the era of antiviral therapy"],"prefix":"10.1097","volume":"62","author":[{"given":"Kyu Sik","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Brain Korea 21 Project of Medical Science,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang\u2010Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine,Seoul,Republic of Korea"},{"name":"Brain Korea 21 Project of Medical Science,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"hep28115-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","year":"2011","journal-title":"Hepatology"},{"key":"hep28115-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.23190","article-title":"Chronic hepatitis B: update 2009","volume":"50","year":"2009","journal-title":"Hepatology"},{"key":"hep28115-bib-0003-20241017","first-page":"1129","article-title":"Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan","volume":"2","year":"1981","journal-title":"Lancet"},{"key":"hep28115-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJMoa013215","article-title":"Hepatitis B e antigen and the risk of hepatocellular carcinoma","volume":"347","year":"2002","journal-title":"N Engl J Med"},{"key":"hep28115-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","article-title":"Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level","volume":"295","year":"2006","journal-title":"JAMA"},{"key":"hep28115-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2012.02.010","article-title":"EASL clinical practice guidelines: management of chronic hepatitis B virus infection","volume":"57","year":"2012","journal-title":"J 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