{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:00:51Z","timestamp":1792155651940,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T00:00:00Z","timestamp":1445040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T00:00:00Z","timestamp":1445040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Instituto de Salud Carlos III, Ministerio de Econom\u00eda y Competitividad (JB)","award":["PI 13\/0341"],"award-info":[{"award-number":["PI 13\/0341"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Nonselective beta\u2010blockers (NSBB) are widely used because they have been proved effective in the prophylaxis of acute variceal bleeding (AVB). However, a significant proportion of patients still experience AVB while on treatment with NSBB, and its impact on prognosis of AVB is unknown. The present study was aimed at assessing the effect of being on prophylactic therapy with NSBB on 5\u2010day failure and 6\u2010week mortality of patients with cirrhosis admitted with AVB. Included were 142 patients: 49 were receiving prophylactic therapy with NSBB (NSBB group) and 93 were not (control group). There were some differences in the baseline characteristics between the groups: higher proportion of alcoholic etiology and active alcoholism (37% versus 10%), higher platelet count, and lower hematocrit at admission in the control group. However, the severity of AVB and initial treatment were similar. Five\u2010day failure occurred in 20% of patients (14% in NSBB versus 24% in controls, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.27). The adjusted odds ratio for 5\u2010day failure under NSBB was 2.46 (95% confidence interval 0.53\u201011.37, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.25). Nineteen patients (13%) died, and two had liver transplantation within 6 weeks. The probability of survival at 6 weeks was 96% in the NSBB group and 82% in the control group (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.02). After adjusting by propensity score and Model for End\u2010Stage Liver Disease score, the NSBB adjusted odds ratio for 6\u2010week mortality was 0.38 (95% confidence interval 0.05\u20102.63, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.32). The estimated association between NSBB with both 5\u2010day failure and 6\u2010week mortality was homogenous across all Model for End\u2010Stage Liver Disease spectrums. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Prophylactic NSBB treatment is not a negative prognostic indicator for the short\u2010term survival of patients with cirrhosis admitted with AVB.(H<jats:sc>epatology<\/jats:sc> 2015;62:1840\u20131846)<\/jats:p>","DOI":"10.1002\/hep.28151","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T16:02:14Z","timestamp":1441382534000},"page":"1840-1846","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Prognosis of acute variceal bleeding: Is being on beta\u2010blockers an aggravating factor? A short\u2010term survival analysis"],"prefix":"10.1097","volume":"62","author":[{"given":"Andrea Ribeiro","family":"de Souza","sequence":"first","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS, University of Barcelona and Centro de Investigaci\u00f3n, Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"La Mura","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS, University of Barcelona and Centro de Investigaci\u00f3n, Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS, University of Barcelona and Centro de Investigaci\u00f3n, Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Garc\u00eda\u2010Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS, University of Barcelona and Centro de Investigaci\u00f3n, Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"Abraldes","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS, University of Barcelona and Centro de Investigaci\u00f3n, Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, Liver Unit,Hospital Cl\u00ednic\u2010IDIBAPS, University of Barcelona and Centro de Investigaci\u00f3n, Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,10,17]]},"reference":[{"key":"hep28151-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJMra0901512","article-title":"Management of varices and variceal hemorrhage in cirrhosis","volume":"362","year":"2010","journal-title":"N Engl J Med"},{"key":"hep28151-bib-0002-20241017","first-page":"332","article-title":"The treatment of portal hypertension: a meta\u2010analytic review","volume":"22","year":"1995","journal-title":"Hepatology"},{"key":"hep28151-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0950-3528(97)90038-5","article-title":"Natural history clinical\u2013hemodynamic correlations. Prediction of the risk of bleeding","volume":"11","year":"1997","journal-title":"Baillieres Clin Gastroenterol"},{"key":"hep28151-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0016-5085(81)90144-X","article-title":"The course of patients after variceal hemorrhage","volume":"80","year":"1981","journal-title":"Gastroenterology"},{"key":"hep28151-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/hep.20339","article-title":"Improved survival after variceal bleeding in patients with cirrhosis over the past two decades","volume":"40","year":"2004","journal-title":"Hepatology"},{"key":"hep28151-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1572-0241.2003.07294.x","article-title":"Improved patient survival after acute variceal bleeding: a multicenter, cohort study","volume":"98","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"hep28151-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1478-3231.2009.02169.x","article-title":"The recent reduction in mortality from bleeding oesophageal varices is primarily observed from days 1 to 5","volume":"30","year":"2010","journal-title":"Liver Int"},{"key":"hep28151-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/gut.49.5.682","article-title":"Improving prognosis following a first variceal haemorrhage over four decades","volume":"49","year":"2001","journal-title":"Gut"},{"key":"hep28151-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/hep.21089","article-title":"Improved prognosis for patients hospitalized with esophageal varices in Sweden 1969\u20102002","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"hep28151-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1056\/NEJM198112033052302","article-title":"Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study","volume":"305","year":"1981","journal-title":"N Engl J Med"},{"key":"hep28151-bib-0011-20241017","first-page":"63","article-title":"Beta\u2010adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta\u2010analysis","volume":"25","year":"1997","journal-title":"Hepatology"},{"key":"hep28151-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/hep.1840360612","article-title":"Randomized comparison of long\u2010term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis","volume":"36","year":"2002","journal-title":"Hepatology"},{"key":"hep28151-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0168-8278(01)00300-2","article-title":"Total effective vascular compliance in patients with cirrhosis. 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