{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:29:15Z","timestamp":1788827355040,"version":"build-2803163510"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/100010559","name":"Children's Hospital of Pittsburgh of UPMC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010559","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Approaches to the management of portal hypertension and variceal hemorrhage in pediatrics remain controversial, in large part because they are not well informed by rigorous clinical studies. Fundamental biological and clinical differences preclude automatic application of approaches used for adults to children. On April 11\u201012, 2015, experts in the field convened at the first Baveno Pediatric Satellite Meeting to discuss and explore current available evidence regarding indications for MesoRex bypass (MRB) in extrahepatic portal vein obstruction and the role of primary prophylaxis of variceal hemorrhage in children. Consensus was reached regarding MRB. The vast majority of children with extrahepatic portal vein obstruction will experience complications that can be prevented by successful MRB surgery. Therefore, children with extrahepatic portal vein obstruction should be offered MRB for primary and secondary prophylaxis of variceal bleeding and other complications, if appropriate surgical expertise is available, if preoperative and intraoperative evaluation demonstrates favorable anatomy, and if appropriate multidisciplinary care is available for postoperative evaluation and management of shunt thrombosis or stenosis. In contrast, consensus was not achieved regarding primary prophylaxis of varices. Although variceal hemorrhage is a concerning complication of portal hypertension in children, the first bleed appears to be only rarely fatal and the associated morbidity has not been well characterized. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: There are few pediatric data to indicate the efficacy and safety of pharmacologic or endoscopic therapies as primary prophylaxis or that prevention of a sentinel variceal bleed will ultimately improve survival; therefore, no recommendation for primary prophylaxis with endoscopic variceal ligation, sclerotherapy, or nonspecific beta\u2010blockade in children was proposed. (H<jats:sc>epatology<\/jats:sc> 2016;63:1368\u20131380)<\/jats:p>","DOI":"10.1002\/hep.28153","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T09:26:39Z","timestamp":1441963599000},"page":"1368-1380","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":149,"title":["Primary prophylaxis of variceal bleeding in children and the role of MesoRex Bypass: Summary of the Baveno VI Pediatric Satellite Symposium"],"prefix":"10.1097","volume":"63","author":[{"given":"Benjamin L.","family":"Shneider","sequence":"first","affiliation":[{"name":"Texas Children's Hospital and the Department of Pediatrics,Baylor College of Medicine,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"de Ville de Goyet","sequence":"additional","affiliation":[{"name":"Bambino Gesu Children's Hospital and Tor Vergata Roma University,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital and the Department of Pediatrics,Baylor College of Medicine,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Sanjay Gandhi Postgraduate Institute of Medical Sciences,Lucknow,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Ling","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children and the Department of Paediatrics,University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Duch\u00e9","sequence":"additional","affiliation":[{"name":"H\u00e9patologie P\u00e9diatrique and Centre de R\u00e9f\u00e9rence National de l'Atr\u00e9sie des Voies Biliaires, Radiologie P\u00e9diatrique, Universit\u00e9 Paris\u2010Sud 11, H\u00f4pital Bic\u00eatre, AP\u2010HP,Le Kremlin\u2010Bic\u00eatre,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McKiernan","sequence":"additional","affiliation":[{"name":"Birmingham Children's Hospital,Birmingham,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Superina","sequence":"additional","affiliation":[{"name":"Lurie Children's Hospital,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Squires","sequence":"additional","affiliation":[{"name":"Children's Hospital of Pittsburgh of UPMC,Pittsburgh,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[{"name":"Hospital Clinic\u2010IDIBAPS and CIBEREHD,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Groszmann","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine,New Haven,CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv K.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences,New Delhi,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"de Franchis","sequence":"additional","affiliation":[{"name":"University of Milan,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Mazariegos","sequence":"additional","affiliation":[{"name":"Children's Hospital of Pittsburgh of UPMC,Pittsburgh,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"hep28153-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/MPG.0b013e318213be81","article-title":"Variation in care for children with esophageal varices: a study of physicians', patients', and families' approaches and attitudes","volume":"52","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jhep.2010.06.004","article-title":"Faculty. Revising consensus in portal hypertension: report of the Baveno V Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"hep28153-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1399-3046.2012.01652.x","article-title":"Portal hypertension in children: expert pediatric opinion on the report of the Baveno V Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension","volume":"16","year":"2012","journal-title":"Pediatr Transplant"},{"key":"hep28153-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0022-3476(83)80460-0","article-title":"Portal obstruction in children. I. Clinical investigation and hemorrhage risk","volume":"103","year":"1983","journal-title":"J Pediatr"},{"key":"hep28153-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/bjs.1800750504","article-title":"Assessment of injection sclerotherapy in the management of 152 children with oesophageal varices","volume":"75","year":"1988","journal-title":"Br J Surg"},{"key":"hep28153-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1440-1746.2007.05102.x","article-title":"Etiological spectrum of esophageal varices due to portal hypertension in Indian children: is it different from the West?","volume":"23","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"hep28153-bib-0007-20241017","first-page":"260A","article-title":"Acute variceal bleeding in children: single center experience","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep28153-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.06.022","article-title":"Experience with endoscopic management of high\u2010risk gastroesophageal varices, with and without bleeding, in children with biliary atresia","volume":"145","year":"2013","journal-title":"Gastroenterology"},{"key":"hep28153-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1053\/j.gastro.2010.07.004","article-title":"Prognostic value of endoscopy in children with biliary atresia at risk for early development of varices and bleeding","volume":"139","year":"2010","journal-title":"Gastroenterology"},{"key":"hep28153-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/MPG.0b013e31825f53e5","article-title":"Endoscopic surveillance and primary prophylaxis sclerotherapy of esophageal varices in biliary atresia","volume":"55","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1067\/mpd.2001.115967","article-title":"Survival after first esophageal variceal hemorrhage in patients with biliary atresia","volume":"139","year":"2001","journal-title":"J Pediatr"},{"key":"hep28153-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1067\/mge.2003.194","article-title":"Endoscopic sclerotherapy in children: experience with 257 cases of extrahepatic portal venous obstruction","volume":"57","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"hep28153-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0022-3468(84)80003-2","article-title":"Management of esophageal varices in children by injection sclerotherapy","volume":"19","year":"1984","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/MPG.0b013e31817b6eea","article-title":"Aetiology and management of extrahepatic portal vein obstruction in children: King's College Hospital experience","volume":"47","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.3748\/wjg.v16.i39.4968","article-title":"Etiology and long\u2010term outcome of extrahepatic portal vein obstruction in children","volume":"16","year":"2010","journal-title":"World J Gastroenterol"},{"key":"hep28153-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1440-1746.2004.03224.x","article-title":"Fifteen\u2010year follow up of endoscopic injection sclerotherapy in children with extrahepatic portal venous obstruction","volume":"19","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"hep28153-bib-0017-20241017","first-page":"217","article-title":"Presentation and natural history of variceal bleeding in patients with portal hypertension due to extrahepatic portal venous obstruction","volume":"22","year":"2003","journal-title":"Indian J Gastroenterol"},{"key":"hep28153-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/01.mpg.0000189351.55666.45","article-title":"Endoscopic outcome beyond esophageal variceal eradication in children with extrahepatic portal venous obstruction","volume":"42","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1053\/jhep.2002.35278","article-title":"Endoscopic ligation compared with sclerotherapy for bleeding esophageal varices in children with extrahepatic portal venous obstruction","volume":"36","year":"2002","journal-title":"Hepatology"},{"key":"hep28153-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/j.1440-1746.2004.03470.x","article-title":"Frequency of gastropathy and gastric varices in children with extrahepatic portal venous obstruction treated with sclerotherapy","volume":"19","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"hep28153-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MPG.0b013e3181b6a55d","article-title":"Quality of life in children managed for extrahepatic portal venous obstruction","volume":"50","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/MPG.0000000000000537","article-title":"Clues for minimal hepatic encephalopathy in children with noncirrhotic portal hypertension","volume":"59","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jhep.2009.12.012","article-title":"Encephalopathy assessment in children with extra\u2010hepatic portal vein obstruction with MR, psychometry and critical flicker frequency","volume":"52","year":"2010","journal-title":"J Hepatol"},{"key":"hep28153-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/MPG.0b013e3181ecaf62","article-title":"Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry","volume":"51","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/liv.12708","article-title":"Hepatopulmonary syndrome in children: a comparative study of non\u2010cirrhotic vs. cirrhotic portal hypertension","volume":"35","year":"2015","journal-title":"Liver Int"},{"key":"hep28153-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpeds.2005.02.019","article-title":"Portopulmonary hypertension in pediatric patients","volume":"147","year":"2005","journal-title":"J Pediatr"},{"key":"hep28153-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1440-1746.2001.02392.x","article-title":"Coagulation profile and platelet function in patients with extrahepatic portal vein obstruction and non\u2010cirrhotic portal fibrosis","volume":"16","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"hep28153-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/hep.1840150210","article-title":"Portal\u2010vein obstruction in children leads to growth retardation","volume":"15","year":"1992","journal-title":"Hepatology"},{"key":"hep28153-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1136\/gut.2006.103606","article-title":"Portal hypertensive biliopathy","volume":"56","year":"2007","journal-title":"Gut"},{"key":"hep28153-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jceh.2014.02.003","article-title":"Portal cavernoma cholangiopathy: consensus statement of a working party of the Indian National Association for Study of the Liver","volume":"4","year":"2014","journal-title":"J Clin Exp Hepatol"},{"key":"hep28153-bib-0031-20241017","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jpedsurg.2013.10.029","article-title":"Intrahepatic portal venous systems in children with noncirrhotic prehepatic portal hypertension: anatomy and clinical relevance","volume":"49","year":"2014","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0032-20241017","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00007890-199607150-00015","article-title":"Original extrahilar approach for hepatic portal revascularization and relief of extrahepatic portal hypertension related to later portal vein thrombosis after pediatric liver transplantation. Long term results","volume":"62","year":"1996","journal-title":"Transplantation"},{"key":"hep28153-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.jamcollsurg.2013.10.024","article-title":"Meso\u2010Rex bypass\u2014a procedure to cure prehepatic portal hypertension: the insight and the inside","volume":"218","year":"2014","journal-title":"J Am Coll Surg"},{"key":"hep28153-bib-0034-20241017","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jamcollsurg.2012.09.013","article-title":"Advantages of the Meso\u2010Rex bypass compared with portosystemic shunts in the management of extrahepatic portal vein obstruction in children","volume":"216","year":"2013","journal-title":"J Am Coll Surg"},{"key":"hep28153-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/01.sla.0000205827.73706.97","article-title":"Correction of extrahepatic portal vein thrombosis by the mesenteric to left portal vein bypass","volume":"243","year":"2006","journal-title":"Ann Surg"},{"key":"hep28153-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/j.jpedsurg.2009.05.016","article-title":"Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico\u2010left portal vein bypass","volume":"44","year":"2009","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0037-20241017","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1542\/peds.2005-1177","article-title":"Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability","volume":"117","year":"2006","journal-title":"Pediatrics"},{"key":"hep28153-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.jpedsurg.2008.11.003","article-title":"Liver nodules after portal systemic shunt surgery for extrahepatic portal vein obstruction in children","volume":"44","year":"2009","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0039-20241017","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00268-007-9356-0","article-title":"The usefulness of distal splenorenal shunt in children with portal hypertension for the treatment of severe thrombocytopenia and leukopenia","volume":"32","year":"2008","journal-title":"World J Surg"},{"key":"hep28153-bib-0040-20241017","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/MPG.0000000000000821","article-title":"Portopulmonary hypertension in liver disease presenting in childhood","volume":"61","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0041-20241017","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/j.gastro.2013.08.026","article-title":"Preventing variceal bleeding in infants and children: is less more?","volume":"145","year":"2013","journal-title":"Gastroenterology"},{"key":"hep28153-bib-0042-20241017","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-3468(00)90203-3","article-title":"Prophylactic sclerotherapy in children with esophageal varices: long\u2010term results of a controlled prospective randomized trial","volume":"35","year":"2000","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0043-20241017","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0022-3468(03)00181-7","article-title":"Endoscopic ligation of esophageal varices for prophylaxis of first bleeding in children and adolescents with portal hypertension: preliminary results of a prospective study","volume":"38","year":"2003","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0044-20241017","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/MPG.0000000000000710","article-title":"Progression to high\u2010risk gastroesophageal varices in children with biliary atresia with low\u2010risk signs at first endoscopy","volume":"60","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0045-20241017","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1053\/j.gastro.2014.04.028","article-title":"When should the beta\u2010blocker window in cirrhosis close?","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"hep28153-bib-0046-20241017","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MPG.0b013e318267c334","article-title":"Endoscopic and pharmacological secondary prophylaxis in children and adolescents with esophageal varices","volume":"56","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep28153-bib-0047-20241017","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1053\/j.gastro.2006.09.013","article-title":"Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review","volume":"131","year":"2006","journal-title":"Gastroenterology"},{"key":"hep28153-bib-0048-20241017","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jhep.2009.04.015","article-title":"Prognostic value of acute hemodynamic response to i.v. propranolol in patients with cirrhosis and portal hypertension","volume":"51","year":"2009","journal-title":"J Hepatol"},{"key":"hep28153-bib-0049-20241017","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jhep.2010.04.027","article-title":"Measurement of hepatic vein pressure gradient in children with chronic liver diseases","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"hep28153-bib-0050-20241017","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0022-3476(85)80316-4","article-title":"Propranalol therapy for portal hypertension in children","volume":"106","year":"1985","journal-title":"J Pediatr"},{"key":"hep28153-bib-0051-20241017","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.23775","article-title":"Deleterious effects of beta\u2010blockers on survival in patients with cirrhosis and refractory ascites","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep28153-bib-0052-20241017","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/gutjnl-2011-301348","article-title":"The window hypothesis: haemodynamic and non\u2010haemodynamic effects of beta\u2010blockers improve survival of patients with cirrhosis during a window in the disease","volume":"61","year":"2012","journal-title":"Gut"},{"key":"hep28153-bib-0053-20241017","doi-asserted-by":"crossref","first-page":"e85760","DOI":"10.1371\/journal.pone.0085760","article-title":"Current clinical evidence on the effect of general anesthesia on neurodevelopment in children: an updated systematic review with meta\u2010regression","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"hep28153-bib-0054-20241017","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.2014-3526","article-title":"Cognition and brain structure following early childhood surgery with anesthesia","volume":"136","year":"2015","journal-title":"Pediatrics"},{"key":"hep28153-bib-0055-20241017","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.3748\/wjg.v19.i13.2053","article-title":"Noninvasive methods for prediction of esophageal varices in pediatric patients with portal hypertension","volume":"19","year":"2013","journal-title":"World J Gastroenterol"},{"key":"hep28153-bib-0056-20241017","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1586\/17474124.2015.993610","article-title":"Advances in the management of childhood portal hypertension","volume":"9","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"hep28153-bib-0057-20241017","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3748\/wjg.v21.i9.2719","article-title":"Endoscopic cyanoacrylate injection for the treatment of gastric varices in children","volume":"21","year":"2015","journal-title":"World J Gastroenterol"},{"key":"hep28153-bib-0058-20241017","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpedsurg.2009.08.019","article-title":"Mesoportal bypass for extrahepatic portal vein obstruction in children: close to a cure for most!","volume":"45","year":"2010","journal-title":"J Pediatr Surg"},{"key":"hep28153-bib-0059-20241017","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/hep.1840170510","article-title":"Biliary abnormalities associated with extrahepatic portal venous obstruction","volume":"17","year":"1993","journal-title":"Hepatology"},{"key":"hep28153-bib-0060-20241017","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1067\/mpd.2003.93","article-title":"Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis","volume":"142","year":"2003","journal-title":"J Pediatr"},{"key":"hep28153-bib-0061-20241017","first-page":"213","article-title":"Mesenterico\u2010left portal vein bypass in children with congenital extrahepatic portal vein thrombosis: a unique curative approach","volume":"36","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201604000-00037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:24:12Z","timestamp":1729211052000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201604000-00037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,23]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.28153","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,23]]},"assertion":[{"value":"2015-06-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}